个人简介

Education Ph.D., North Carolina State University, 1981 B.S.H.E., University of Delaware, 1974 Professional Experience Post-Doctoral Fellowship, The Johns Hopkins University, 1981-1982 Research Associate, Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 1982-1985 Assistant Professor, Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 1985-1991 Associate Professor, Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 1991-2000 Director, Functional Imaging Laboratory, Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, 1999-2000 Associate Professor; Department of Chemistry, University of Missouri-Columbia, 2000-present Biomedical Program Director; MU Research Reactor, University of Missouri-Columbia, 2000-present Recent Honors and Awards, Activitiess 2013, “Excellence in Education” Awardee for 2013, an MU Campus Award. 2012, The Molecular Imaging and Contrast Agent Database (of the National Institutes of Health) added one of our diagnostic imaging compounds, [125I](E)-N-1-(3’-iodoallyl)-N’-4-(3’’, 4’’-dimethoxyphenyl)-piperazine “[125I]E-1.” Document created by Liang Shan August 16, 2012 2010, Honorary Coach for the Mizzou Gymnastics program 2010, The Molecular Imaging and Contrast Agent Database (of the National Institutes of Health) added one of our diagnostic imaging compounds, “[111In]Bomproamide.” Document created by Arvind Chopra May 20, 2010 2007 – 2010, Temporary Member, National Institutes of Health - National Cancer Institute: Radiation Therapeutics and Biology Study Section, Oncological Sciences Integrated Review Group 2007 – present, NEXUS (a minority science network) Advisory Committee 2007 – 2010, Personnel Committee of the Chemistry Department (elected position) 2006, “Purple Chalk Award” for Excellence in Teaching in the College of Arts and Science 2005, Honorary Coach, MU Women’s Soccer Team 2005, Wakonse Fellow 2005, Who's Who Among America's Teachers ®, 2004-2005 (student nomination)

研究领域

Organic and Bioconjugate Chemistry, Radiopharmaceutical Development, Radiotracer synthesis, Structure-Activity Relationships, Medicinal Chemistry, Boron analysis in plants

My research utilizes synthetic organic chemistry, radiochemistry and nuclear chemistry to learn more about the human brain with diagnostic imaging tracers, treating cancer with radiotherapeutic constructs and plants with analytical and tracer techniques. Currently, within the diagnostic imaging arena, we have developed a novel radioiodinated tracer that has good pharmacokinetics and selectivity to bind sigma 1 receptors in vivo. This novel tracer can monitor the binding of cocaine to the sigma 1 receptor in mice at pharmacologically relevant doses. My collaborators and I are interested in the development of anti-cocaine medications using this approach. Furthermore, we synthesize novel compounds that are evaluated for their affinity and selectivity to the sigma receptor subtypes, receptors that are implicated in a number of psychiatric diseases and cancer.

近期论文

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Ramalingam, B.; Brockman, J.; Zhou, Y.; Mukherjee, S.; Zheng, H.; Lee, M; Gangopadhyay, K.; Gangopadhyay, S., Direct Conversion Neutron Detectors with Integrated PtNP and 10B, (manuscript submitted, 2014). Huang, P.; Lee, M. W.; Heruth, D. P.; Sokolovsky, I. V.; Nsumu, N. N.; Grigoryev, D.; Zhang, L.; Ye, Q.; Ye, S. Q., MC-bpep as a new and potent inhibitor of endothelial permeability and inflammation. Proceedings of the American Thoracic Society, 2014 Romanos, J.; Beckner, M.; Stalla, D.; Tekeei, A.; Suppes, G.; Jalisatgi, S.; Lee, M. W.; Hawthorne, M.; Robertson, J. D.; Firlej, L., Infrared study of boron-​carbon chemical bonds in boron-​doped activated carbon, Carbon, 54, 208-14, 2013. Mutz, M.; Eastwood, E.; Lee Jr, M. W.; Bowen, D.; Dadmum, M., Qunatifying the thermodynamic interactions of polyhedral boranes in solution to guide nanocomposite fabrication., J. Nanopart. Res., 14, 1237, 2012. Lee Jr., M. W.; Sevryugina, Y.; Khan, A.; Ye, S. Q.; Carboranes Increase the Potency of Small Molecule Inhibitors of Nicotinamide Phosphoribosyltranferase. J. Med. Chem, 55, 7290-94, 2012. Heber, E. M.; Lee Jr., M. W.; Hawthorne, M.; Garabalino, M. A.; Molinari, A. J.; Nigg, D. W.; Bauer, W.; Hughes, A. M.; Pozzi, E. C.; Trivillin, V. A.; Schwint, A. E.; Boron delivery with liposomes for Boron Neutron Capture Therapy (BNCT): Biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential. Rad. Envir. Biophys. 51, 195-204, 2012. Goswami, L.; Chakravarty, C.; Lee Jr. M. W.; Jalisatgi, S.; Hawthorne, M., Extensions of the Icosahedral Closomer Structure by Using Azide-Alkyne Click Reactions. Angew. Chem. Int. Ed. 46, 17, 3018-22, 2011. Jalisatgi, S.; Kulkarni, V. S.; Tang, B.; Houston, Z.; Lee Jr., M. W.; Hawthorne, M., A Convenient Route to Diversely Substituted Icosahedral Closomer Nanoscaffolds. J. Am. Chem. Soc. 133, 12382-85, 2011. Lee Jr, M. W.Xu R, Lord SA, Peterson RM, Fergason-Cantrell EA, Lever JR, Lever SZ. Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporter. Bioorganic and Medicinal Chemistry, under review. Wang X, Brockman J, Guthrie J, Durback A, Ladd R, Robertson JD, McSteen P, Lever SZ. Neutron Capture Radiography (NCR) of boron distribution in maize. Presented at the 248th American Chemical Society National Meeting, August 10-14, 2014, San Francisco, CA. Lever JR, Miller DK, Fergason-Cantrell EA, Green CL, Watkinson LD, Carmack TL, Lever SZ. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine’s motor stimulatory effects in mice by PD14418. J. Pharmacol. Exp. Ther. ePub August 6, 2014; doi:10.1124/jpet.114.216671 Brust P, Deuther-Conrad W, Becker G, Patt M, Donat CK, Stittsworth S, Fischer S, Hiller A, Wenzel B, Dukic-Stefanovic S, Hess S, Steinback J, Wünsch B, Lever SZ, Sabri O. Distinctive in vivo kinetics of the new sigma1 receptor ligands (R)-(+)- and (S)-(-)-18F-Fluspidine in porcine brain. J. Nucl. Med. ePub July 28, 2014; doi: 10.2967/jnumed.114.137562 Lever JR, Miller DK, Green CL, Fergason-Cantrell EA, Watkinson LD, Carmack TL, Fan K-H, Lever SZ. A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice. Synapse. 2014; 68:73-84. Sage AS, Oelrichs CE, Davis DC, Fan K-H, Nahas RI, Lever SZ, Lever JR, Miller DK. Effects of N-phenylpropyl-N´-substituted piperazine sigma receptor ligands on cocaine-induced hyperactivity in mice. Pharmacol., Biochem. Behav. 2013; 110:201-207. Lever SZ, Xu R, Fan K-H, Fergason-Cantrell EA, Carmack TL, Watkinson LD, Lever JR. Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogs. Nucl. Med. Biol. 2012; 39:401 – 414.PMID: 22172395. Xu R, Watkinson LD, Carmack TL, Lever JR, Lever SZ. Synthesis, Sigma Receptor Binding Studies, and in vivo Evaluation of Radioiodinated (Z)- and (E)-iodoallyl Analogs of SA4503. Med. Chem. 2012; 2:131-136. Fan K-H, Lever JR, Lever SZ. Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors, Bioorg. Med. Chem. 19: 1852-1859. 2011. Akgun Z, Engelbrecht H, Fan K-H, Barnes CL, Cutler CS, Jurisson SS, Lever SZ. The complexation of rhodium(III) with acyclic diaminedithioether (DADTE) ligands. Dalton Trans. 39:10169-10178, 2010. Abd-Elgaliel WR, Gallazzi F, Garrison J, Rold T, Sieckman G, Daibes Figueroa S, Hoffman TJ, Lever SZ. Design, Synthesis and Biological Evaluation of a Radiolabelled Antagonist-Bombesin Analog as Targeting Vector. Bioconjugate Chem. 19:2040-2048, 2008.; Safronov, A.; Jalisatigi, S.; Hawthorne, M., Cesium dodecahydroxy-closo-dodecaborate: Cs2[B12(OH)12],” Inorg. Synth., 2010.