个人简介

Education BA, University of California, Santa Barbara, 1999 PhD, University of California, Los Angeles, 2005 Professional Experience Assistant Professor, University of Missouri-Columbia, 2012-present Research Investigator, Department of Radiology, University of Missouri-Columbia, 2006-2012 Postdoctoral Fellow, University of California, Los Angeles, 2005-2006 Honors and Awards Excellence in Teaching Award, UCLA Department of Chemistry and Biochemistry, 2001 Chancellor's Scholar, University of California, Santa Barbara, 1998

研究领域

Polyhedral Boron Chemistry

Our research focuses on biomedical, analytical, and material science applications of polyhedral boranes. Targeted Drug Delivery – Using carboranes, our group has developed a class of highly potent anticancer agents which exhibit sub-nanomolar activity against a wide range of human cancer cell lines in vitro. These drugs inhibit the NAD+ recycling pathway which has implications in a wide-range of diseases, including cancer, Alzheimer’s disease, and diabetes. We are currently developing a class of cancer-specific targeted prodrugs of these exceptionally potent molecules. Material Science Applications of Polyhedral Boranes –The higher closo polyhedral borane anions, such as dodecaborate, [B12H12]2- possess extraordinary thermo and oxidative stability. Many of these species also exhibit remarkable electronic properties. To date, there are few real-world applications for these substances. Our group is currently exploring and expanding the scope of known substitution chemistry of these clusters, focusing on potential applications in alternative energy and materials science. Imaging Mass Spectrometry – A relatively new and exciting area of research for us is Imaging Mass Spectrometry. In this research, we couple a high-precision laser with an ultra-high resolution mass spectrometer. This gives us the ability to visualize the spatial distribution of proteins, peptides, lipids, drugs, metabolites, etc., directly from plant or animal tissue sections. The emphasis of our work is the visualization of drug molecules and their metabolites in tumor and other tissues. For this purpose, our research group has recently installed a 7-Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR-MS), equipped for high resolution MALDI Imaging.

近期论文

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Ramalingam, B.; Brockman, J.; Zhou, Y.; Mukherjee, S.; Zheng, H.; Lee, M; Gangopadhyay, K.; Gangopadhyay, S., Direct Conversion Neutron Detectors with Integrated PtNP and 10B, (manuscript submitted, 2014). Huang, P.; Lee, M. W.; Heruth, D. P.; Sokolovsky, I. V.; Nsumu, N. N.; Grigoryev, D.; Zhang, L.; Ye, Q.; Ye, S. Q., MC-bpep as a new and potent inhibitor of endothelial permeability and inflammation. Proceedings of the American Thoracic Society, 2014 Romanos, J.; Beckner, M.; Stalla, D.; Tekeei, A.; Suppes, G.; Jalisatgi, S.; Lee, M. W.; Hawthorne, M.; Robertson, J. D.; Firlej, L., Infrared study of boron-​carbon chemical bonds in boron-​doped activated carbon, Carbon, 54, 208-14, 2013. Mutz, M.; Eastwood, E.; Lee Jr, M. W.; Bowen, D.; Dadmum, M., Qunatifying the thermodynamic interactions of polyhedral boranes in solution to guide nanocomposite fabrication., J. Nanopart. Res., 14, 1237, 2012. Lee Jr., M. W.; Sevryugina, Y.; Khan, A.; Ye, S. Q.; Carboranes Increase the Potency of Small Molecule Inhibitors of Nicotinamide Phosphoribosyltranferase. J. Med. Chem, 55, 7290-94, 2012. Heber, E. M.; Lee Jr., M. W.; Hawthorne, M.; Garabalino, M. A.; Molinari, A. J.; Nigg, D. W.; Bauer, W.; Hughes, A. M.; Pozzi, E. C.; Trivillin, V. A.; Schwint, A. E.; Boron delivery with liposomes for Boron Neutron Capture Therapy (BNCT): Biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential. Rad. Envir. Biophys. 51, 195-204, 2012. Goswami, L.; Chakravarty, C.; Lee Jr. M. W.; Jalisatgi, S.; Hawthorne, M., Extensions of the Icosahedral Closomer Structure by Using Azide-Alkyne Click Reactions. Angew. Chem. Int. Ed. 46, 17, 3018-22, 2011. Jalisatgi, S.; Kulkarni, V. S.; Tang, B.; Houston, Z.; Lee Jr., M. W.; Hawthorne, M., A Convenient Route to Diversely Substituted Icosahedral Closomer Nanoscaffolds. J. Am. Chem. Soc. 133, 12382-85, 2011. Lee Jr, M. W.; Safronov, A.; Jalisatigi, S.; Hawthorne, M., Cesium dodecahydroxy-closo-dodecaborate: Cs2[B12(OH)12],” Inorg. Synth., 2010.