赵昌明 - 武汉大学

个人简介

学习经历： 2017.9---现在，波士顿大学，化学系，访问学者 2010.6---2011.12，伊利诺伊大学香槟校区（UIUC）基因组生物研究所，博士后 2008.6---2010.5，上海交通大学，生命科学学院，博士后 2001.9---2007.12，华中农业大学，生命科学技术学院，博士 1997.9---2001.7，华中农业大学，生命科学技术学院，本科工作经历： 2012.1---现在，武汉大学药学院

研究领域

微生物来源的含磷天然产物的发掘与生物合成研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C*. Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production. Synth Syst Biotechnol. 2019 Ma;4(1):34-39. doi: 10.1016/j.synbio.2018.12.003 2. Chen L#, Naowarojna N#, Chen B, Xu M, Quill M, Wang J, Deng Z, Zhao C*, and Liu P*. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS Catal. 2019, 9(1): 253-258. doi: 10.1021/acscatal.8b03903 3. Naowarojna N#, Cheng R#, Chen L#, Quill M, Xu M, Zhao C*, Liu P*. Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis. Biochemistry. 2018 Jun 19;57(24):3309-3325. doi: 10.1021/acs.biochem.8b00239. 4. Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C*, Liu P*. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation. J Am Chem Soc. 2018 Apr 4;140(13):4604-4612. doi: 10.1021/jacs.7b13628. 5. Deng Q, Zhou L, Luo M, Deng Z, Zhao C*. Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers. Synth Syst Biotechnol. 2017 Mar 24;2(1):59-64. doi: 10.1016/j.synbio.2017.03.001. 6. Li M, Chen L, Deng Z, Zhao C*. Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins. FEBS Open Bio. 2016 May 16;6(6):603-9. doi: 10.1002/2211-5463.12071. 7. Chen L, Li P, Deng Z, Zhao C*. Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola. Sci Rep. 2015 Aug 10;5:12892. doi: 10.1038/srep12892. 8. Hao C#, Huang S#, Deng Z, Zhao C*, Yu Y*. Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLoS One. 2014 Jun 5;9(6):e99077. doi: 10.1371/journal.pone.0099077. 9. Evans BS*, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW*. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. ACS Chem Biol. 2013 May 17;8(5):908-13. doi: 10.1021/cb400102t. 10. Zhao C, Huang T, Chen W, Deng Z*. Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster. Appl Environ Microbiol. 2010. 76(21):7343-7347 11. Zhao C, Song C, Yu Z and Sun M*. L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520. FEBS Lett. 2008. 582(20):3125-3131 12. Zhao C, Zeng H, Yu Z and Sun M*. N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus. Biotechnol Bioeng. 2008. 100(3):599-603 13. Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z and Sun M*. Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520. Arch Microbiol. 2007. 187(4):313-319