吴松 - 武汉大学

个人简介

学习经历 1989.9-1993.6 湖北大学化学系本科有机专业 2000.9-2005.12 武汉大学化学院博士化学生物学 2009.5-2011.5 斯坦福大学医学院博士后抗肝癌药物的合成及肿瘤的早期检测（成像研究）工作经历 1993.6-2000.5 湖北省沙市一中高中教师 2005.12-今武汉大学药学院药物化学所教师

研究领域

1.抗肝癌药物的研究设计合成针对肝癌患者高表达的靶标(某些酶及受体)的高活性抑制剂，并对其进行包括分子生物学、细胞生物学及动物模型在内的临床前评价的研究（与斯坦福大学亚洲肝病中心the Asian Liver Center at Stanford合作）。 2.非侵入性肿瘤荧光探针的研究利用肿瘤细胞靶标表达的差异，设计并合成可与靶标特异性结合的具有高对比度、高分辨率的体外/体内荧光探针

近期论文

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Kang Lu, Yu Wang, Hao Zhang, Cuiqing Tian, Wenxiang Wang, Tian Yang, Baiwen Qi, Song Wu*. Rational Design of a Theranostic Agent Triggered by Endogenous Nitric Oxide in a Cellular Model of Alzheimer’s Disease. J. Med. Chem., 2022, DOI: 10.1021/acs.jmedchem.2c00399. Hengtang Mai, Yu Wang, Shuang Li, Ruizhen Jia, Sixian Li, Qian Peng, Yan Xie, Xiang Hu, Song Wu*. A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice. Chem. Commun., 2019, 55, 7374-7377. Ruizhen Jia, Pengfei Song, Jingjing Wang, Hengtang Mai, Sixian Li, Yu Cheng, Song Wu*. Self-Assembled Fluorescent Nanoprobe Based on Forster Resonance Energy Transfer for Carbon Monoxide in Living Cells and Animals via Ligand Exchange. Anal. Chem., 2018, 90: 7117~7121. Jin Chen, Lingyu Zeng , Tian Xia, Shuang Li, Tengfei Yan, Song Wu*, Guofu Qiu, Zhihong Liu*. Toward a Biomarker of Oxidative Stress: A Fluorescent Probe forExogenous and Endogenous Malondialdehyde in Living Cells. Anal. Chem., 2015, 87: 8052~8056. (Reported by C&EN) Tengfei Yan, Jin Chen, Song Wu*, Zhiqiang Mao, Zhihong Liu*. A rationally designed fluorescence chemosensor for on-site monitoring of carbon monoxide in air. Org. Lett.，2014, 16, 3296-3299.