李艳琴 - 武汉大学

个人简介

学习经历： 2008 – 2009 博士后药理学美国匹兹堡大学医学院药理系 2005 – 2008 博士药理学北京大学 2003 – 2004 联合培养研究生北京301医院/第二炮兵总医院 2002 – 2005 硕士病理生理学武汉大学 1997 – 2002 学士临床医学武汉大学工作经历： 2010 – 至今副教授药理学武汉大学药学院

研究领域

1、药物滥用和成瘾阿片类物质及其他神经活性物质（可卡因类、大麻类、酒精、尼古丁等）成瘾的神经药理机制及药物作用靶标新发现，动物模型及治疗新药研发；2、神经精神疾病药物研究主要包括精神分裂症和抑郁症的神经病理机制及新药作用机制研究；3、代谢性疾病神经机制及药物研究主要包括肥胖、糖尿病等中枢神经内分泌病理调节机制及疾病预防药物的研究；4、新药临床前评价包括治疗神经精神系统疾病、肿瘤、心血管疾病、消化系统疾病等药物的临床前药理及药效评价。

近期论文

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1、Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31(14):5436-46. 2、Li YQ, Li FQ, Wang XY, Wu P, Zhao M, Xu CM, Shaham Y, Lu L. Central amygdala ERK signaling pathway is critical to incubation of opiate craving. J Neurosci. 2008 Dec 3;28(49):13248-57. 3、Li YQ, Wang XY, Zhai HF, Zheng YQ, Zhang XY, Kosten T, Lu L.. Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats. Psychopharmacology (Berl). 2008 Aug;199(2):245-53. 4、Li YQ, Wang XY, Zhai HF, Zhang XY, Kosten T, Lu L. Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats. Behav Brain Res. 2008 Jan 10;186(1):138-42. 5、Zhai H, Li YQ (co-first author), Wang X, Lu L.. Drug-induced alterations in extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement (review). Cell Mol Neurobiol. 2008 Feb;28(2):157-72. 6、Fang Q, Li FQ, Li YQ, Xue YX, He YY, Liu JF, Lu L, Wang JS. Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats. Pharmacol Biochem Behav. 2011 Oct;99(4):738-42. Epub 2011 Jun 23. 7、Li FQ, Xue YX, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L. Basolateral amygdala Cdk5/p35 activity mediates cocaine rewarding memory. J Neurosci, 2010 Aug 4;30(31):10351-9. 8、Yu LL, Wang XY, Zhao M, Liu Y, Li YQ, Li FQ, Wang X, Xue YX, Lu L. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice. Psychopharmacology (Berl). 2009 Jun;204(2):203-11. 9、Wang XY, Zhao M, Ghitza UE, Li YQ, Lu L. Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdale. J Neurosci. 2008 May 21;28(21):5602-10. 10、Liu J, Li YQ , Ouyang JP et al. Protective effects of NADH on cardiac fibroblasts apoptosis induced by hydrazine. Med J Chin PLA. (2008) 33: 305-307. 11、Li YQ , Liu J, Ouyang JP , et al. The mechanism of the apoptosis of cardiac fibroblast induced by hydrazine. Chin J Aerospace Med, (2006)17: 176-179. 12、Li YQ , Liu J, Ouyang JP , et al. Effect of hydrazine on Proliferation and apoptosis of cardiac fibroblast. Medical Journal of Wuhan University. (2005)26: 326-328.