个人简介

Education BA, San Diego State University, 1995 MS, Arizona State University, 1998 PhD, Arizona State University, 2000 Professional Experience Associate Professor, University of Missouri-Columbia 2013-present Assistant Professor, University of Missouri-Columbia, 2005-2013 Postdoctoral Fellow, Princeton University, 2002-2005 Postdoctoral Fellow, Naval Research Laboratory, 2000-2002 Honors and Awards NSF Career Award, 2012 Ruth L. Kirschstein National Research Service Award, 2003-2005 National Research Council Postdoctoral Fellowship, 2000-2002

研究领域

Analytical, Biophysical, Protein Dynamics, Molecular Spectroscopy, Chemometrics

The lab's current research foci include analytical, biophysical and educational research projects. Group Website Our research is focused on the use of spectroscopic techniques, including deep-UV resonance Raman, to study protein structure, folding and dynamics. Selective excitation of the polypeptide backbone amide by UV light increases the intensity of the structurally sensitive amide modes in the UVRR spectra of proteins. We are primarily interested in using deep-UVRR spectroscopy to study protein-protein, protein-lipid and protein-small molecule interactions. Current projects include studies of lipid mediated folding of disordered (unfolded) peptides and the effect of oligomeric proteins on membrane integrity. Multi-excitation UV resonance Raman (ME-UVRR) spectra represent a unique type of data that may be exploited to aide in the a priori deconvolution of the highly overlapped UV Raman bands of proteins. Current research projects involve developing robust chemometric methods for analysis of these multidimensional UVRR spectra for modeling peptide secondary structure, folding and conformational transitions. The Chemistry Immersion Program (CHIP) is an educational outreach program for high school teachers and students aimed at increasing interest in chemistry and chemical measurement and spectroscopic technologies while improving students and teachers technology skill set. More information about CHIP can be found on the CHIP website, at our Facebook page or follow us on Twitter @muaschip.

近期论文

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Halsey C. M., Benham D. A., JiJi R. D., Cooley J. W. (2012) Influence of the lipid environment on valinomycin structure and cation complex formation. Spectrochim Acta A Mol Biomol Spectrosc, 96:200-206. Link Roach C. A., Simpson J. V., JiJi R. D., (2012) Evolution of quantitative methods in protein secondary structure determination via deep-ultraviolet resonance Raman spectroscopy. Analyst, 137(3):555-562. Link Halsey, C. M., Xiong, J., Oshokoya, O. O., Johnson, J. A., Shinde, S., Beatty, J. T., Ghirlanda, G., JiJi, R. D., Cooley, J. W., (2011) Simultaneous observation of peptide backbone lipid solvation and α-helical structure by deep-UV resonance Raman spectroscopy. ChemBioChem, 12(14):2125-2128. Link Halsey C. M., Oshokoya O. O., JiJi R. D., Cooley J. W. (2011) Deep-UV Resonance Raman Analysis of the Rhodobacter capsulatus Cytochrome bc(1) Complex Reveals a Potential Marker for the Transmembrane Peptide Backbone. Biochemistry, 50(30):6531-6538. Link Wang, M. and JiJi, R. D. (2011) Spectroscopic detection of β-sheet structure in nascent Aβ oligomers. J. Biophotonics, 4(9):637-644. Link Wang, M. and JiJi, R. D. (2011) Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy. Biophys. Chem., 158(2-3):96-103. Link Simpson, J. V., Oshokoya, O., Wagner, N., Liu, J., JiJi, R. D. (2011) Pre-processing of ultraviolet resonance Raman spectra. Analyst, 136(6):1239-47. Link Simpson, J. V., Burke, M., JiJi, R. D. (2011) Application of EEM fluorescence in combination with PARAFAC analysis to simultaneously monitor quercetin in its deprotonated, aggregated, and protein bound states. J. Chemometr., 25(3):101-108. Link Simpson, J. V. Balakrishnan, G., JiJi, R. D. (2009) MCR-ALS analysis of two-way UV resonance Raman spectra to resolve discrete protein secondary structural motifs. Analyst, 134(1): 138-147. Link Schooley, E. K., McGee Turner J.B., JiJi R.D., Spinka C. M., Reinero C.R. (2007) Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma. Am. J. Vet. Res. 68(11):1265-1271. Link JiJi, R. D., Balakrishnan, G., Hu, Y., and Spiro, T. G. (2006) Intermediacy of poly(L-proline) II and b-strand conformations in poly(L-lysine) b-sheet formation, probed by temperature-jump/UV resonance Raman spectroscopy. Biochemistry, 46: 34-41. Link