虞沂 - 武汉大学

个人简介

学习简历： 1996.9 – 2002.6 华中农业大学生物技术基地班，本硕连读 2003.9 – 2007.6 中科院微生物研究所，博士工作简历： 2007.7 – 2009.6 上海交通大学生命科学技术学院生物工程系，讲师 2007.3 – 2009.6 上海有机化学研究所，合作研究 2009.7 – 2010.6 华中农业大学生命科学技术学院，讲师 2012.8 – 2013.8 美国Washington University in Saint Louis, 访问学者 2010.7 至今武汉大学药学院，副教授、教授、博导 2018.1 – 2018.12 英国牛津大学，高级访问学者

研究领域

以中草药和微生物来源天然产物为基础，研制和开发新药一直是国际化学界和医药界共同关注的重点领域。天然产物的生物合成是以小分子的简单化合物作为底物，经过一系列顺序催化反应，最终形成复杂化学结构的过程。本人的研究兴趣在于通过代谢工程和组合生物合成研究植物和微生物来源的复杂天然产物的生物合成，即利用基因工程技术，有目的地对细胞代谢途径进行精确的修饰或改造，以提高目的天然产物活性或产量、或合成新的代谢产物；或是通过操纵天然产物生物合成途径中的基因来产生非天然的天然产物类似物库，并从中发现和发展更具应用价值的药物。

近期论文

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1. Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y.*, Zhang Q*. Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ. Nature Communications, 2017, 8(1):437. DOI: 10.1038/s41467-017-00439-1 2. Yu Y., Zhang Q., Deng Z., Parallel pathways in the biosynthesis of aminoglycoside antibiotics. F1000Res. 2017, doi: 10.12688/ f1000research.11104.1 3. Su Li, Zhang R, Kyeremeh K, Deng Z, Deng H* and Yu Y*. Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution. Organic & Biomolecular Chemistry, 2017, 15(18): 3843-3848 4. Ding W, Li Y, Zhao J, Ji X, Mo T, Qianzhu H, Tu T, Deng Z, Yu Y, Chen F, Zhang Q*. The Catalytic Mechanism of the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Angew Chem Int Ed Engl., 2017, 56(14):3857-3861 5. Ding W, Wu Y, Ji X, Qianzhu H, Chen F, Deng Z, Yu Y, Zhang Q*. Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN. Chem Commun (Camb)., 2017, 53(37):5235-5238 6. Su Li, Lv Meinan, Kyeremeh Kwaku, Deng Zixin, Deng Hai and Yu Yi *. A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation. Organic & Biomolecular Chemistry, 2016, 14(37): 8679-8684 7. Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Yi* and Zhang Q*. Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis. J AM CHEM SOC, 2016, 138(20):6427-35 8. Huang S., Elsayed S., Lv M., Tabudravu J., Rateb M., Gyampoh R., Kyeremyh K., Ebel R., Jaspars M., Deng Z., Yu Yi* and Deng H.* Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps. Chemistry & Biology, 2015, 22(12):1633-42 9. Lv Meinan, Zhao Junfeng, Deng Zixin and Yu Yi*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic. Chemistry & Biology, 2015, 22(10):1313-1324. 10. Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Yi* and Deng H*. Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins. Angew Chem Int Ed Engl. 2015, 54(43):12697-12701 11. Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y.*. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137. Anticancer Agents Med Chem, 2015, 15(3):277-84. 12. Liu G, Zhang M, Mo T, He L, Zhang W, Yu Y*, Zhang Q*, Ding W*. Metabolic flux analysis of the halophilic archaeon Haladaptatus paucihalophilus. Biochem Biophys Res Commun., 2015, 467(4):1058-62 13. Long Ma, Axel Bartholome, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh, Hai Deng* and David O'Hagan*. Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-tri-hydroxypentanoic acid. Chemical Science, 2015, 6(2):1414-1419 14. Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y.* Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLOS ONE, 2014, 9(6):e99077. 15. Qin Zhiwei, Wang Xiaoling, Rateb Mostafa, Ass'ad Lina, Jaspars Marcel, Deng Zixin, Yu Yi, Deng Hai*. Disruption of a Methyltransferase Gene in Actinomycin G Gene Cluster in Streptomyces iakyrus Increases the Production of Phenazinomycin. FEMS Microbiology Letters, 2014, 352(1): 62-8 16. Sheng Huang, Long Ma, Ming Him Tong, Yi Yu*, David O'Hagan and Hai Deng* Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674. Org Biomol Chem, 2014, 12(27): 4828-4831 17. Varman, A.M. #, Yu, Y. #, You L., Tang, Y.J. Photoautotrophic production of D-lactate in an engineered cyanobacterium. Microbial Cell Factories, 2013, 12: 117 (#Contributed equally) 18. Qin, Z., Huang, S., Yu, Y.*, Deng, H*. Dithiolopyrrolone natural products: isolation, synthesis and biosynthesis. Marine Drugs, 2013, 11(10):3970-97