王连荣 - 武汉大学

个人简介

2011-至今武汉大学药学院教授 2008-2011 美国麻省理工学院生物工程系博士后 2006-2008 美国麻省理工学院生物工程系访问博士生 2003-2008 上海交通大学生命科技学院硕博连读 1999-2003 山东大学生命科学院本科

研究领域

1.表观遗传学及其生物医学应用 2.DNA修饰对细菌生命活动的影响。

近期论文

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1. Chen C#, Wang L#, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114. (*co-first author) 2. Cao B , Chen C , DeMott M , Cheng Q , Clark T, Xiong X, Zheng X, Butty V , Levine S, Yuan G, Boitano M, Luong K, Song Y, Deng Z, Zhou X, Turner S, Korlach K, You D*, Wang L*, Chen S*, Dedon P. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 2014, 5:3951. (co-corresponding author) 3. Li Y, Liu J, Wang Y, Chan H, Wang L*, Chan W*. Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin. Analytical Chemistry, 2015, 87, 7958−7963. 4. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2017, online March 15th. (#co-first author) 5. Wang L#, Chen S#, Xu T, Taghizadeh K, Wishnok JS, Zhou X, Deng Z, Dedon PC. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 2007, 3(11):709-10. 6. Wang L, Chen S, Vergin KL, Giovannoni Sj. Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci USA. 2011, 108(7):2963-8. 7. Gan R, Wu X, He W, Liu Z, Wu S, Chen C, Chen S, Xiang Q, Deng Z, Liang D, Chen S*,Wang L*. DNA phosphorothioate modifications influence the global transcriptional response and protect DNA from double-stranded breaks. Scientific Reports. 2014 Oct 16;4:6642. 8. Wang L, Chen S, Xiao X, Huang X, You D, Zhou X, Deng Z. arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. Strain FR-008. Applied and Environmental Microbiology. 2006, 72(5):3738-42. 9. Wang L., Chen S., Deng Z. Phosphorothioation: an unusual post-replicative modification on the DNA backbone. Book Chapter. DNA replication. 2011. 10. You D, Wang L, Yao F, Zhou X, Deng Z. A novel DNA modification by sulfur:DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans. Biochemistry. 2007, 46(20):6126-33. 11. Chen S, Wang L, Deng Z. Twenty years hunting for sulfur in DNA. Protein Cell. 2010, 191:14-21. 12. Chan W, Chen B, Wang L, Taghizadeh K, Demott MS, Dedon PC. Quantification of the 2-deoxyribonolactone and nucleoside 5’-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA. J Am Chem Soc.2010, 132(17):6145-53. 13. Xu T, Liang J, Chen S, Wang L, He X, You D, Wang Z, Li A, Xu Z, Zhou X, Deng Z. DNA phosphorothioation in Streptomyces lividans:mutational analysis of the dnd locus. BMC Microbiology, 2009, 9:41. 14. Chen S, Mao X, Shen Y, Zhou Y, Li J, Wang L, Tao X, Yang L, Wang Y, Zhou X, Deng Z, Wei D. Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and Environmental Microbiology, 2009,75(6):1778-81.