个人简介

Education BS, Emporia State University, 1983 PhD, The University of Texas at Austin, 1987 Professional Experience Director, MU NMR Facility, University of Missouri–Columbia, 2007-present Director, Charles W. Gehrke Proteomics Center, University of Missouri–Columbia, 2008-present; Co-Director 2001-2008 Office of Research Faculty Fellow, University of Missouri–Columbia, 2004-2008 Director, Chemistry Mass Spectrometry Facility, 1997-present Associate Professor, University of Missouri, 1994-present Assistant Professor, University of Missouri, 1989-1994 Postdoctoral Research Associate, IBM T. J. Watson Research Center, 1987-1989

研究领域

Physical and Analytical Chemistry, Biological Mass Spectrometry, Kinetics and Spectroscopy of Surface Reactions on Semiconductor Surfaces, Chemical Sensors

In my laboratory, experimental work is being conducted in the areas of surface chemistry and mass spectrometry. We are interested in determining surface reaction mechanisms for catalytic processes and organic thin film formation. We are also interested in developing new methods for determining the bioactive components from dietary botanical supplements and proteomics. These latter areas are interdisciplinary and involve active collaborations with biochemistry, animal sciences and bioinformatic research groups.

近期论文

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Agnes Simonyi, Zihong Chen, Jinghua Jiang, Yijia Zong, Dennis Y. Chuang, Zezong Gu, Chi-Hua Lu, Kevin L. Fritsche, C. Michael Greenlief, Andrew L. Thomas, Dennis B. Lubahn and Grace Y. Sun, “Inhibition of Microglial Activation by Elderberry Extracts and Its Phenolic Components,” Life Sciences, 2015, 128: 30-38, doi: 10.1016/j.lfs.2015.01.037. Hanzhi Wu, Mitch C. Johnson, Chi-Hua Lu, Kevin L. Fritsche, Andrew L. Thomas, Zongwei Cai and C. Michael Greenlief, “Determination of Anthocyanins and Total Polyphenols in a Variety of Elderberry Juices By UPLC/MS and Other Methods,” Acta Horticulturae, 2015, 1061: 43-51. Hanzhi Wu, Mitch C. Johnson, Chi-Hua Lu, Kevin L. Fritsche, Andrew L. Thomas, Zongwei Cai and C. Michael Greenlief, “Peptidomics study in anthocyanin abundant juice of elderberry,” Talanta, 2015, 131: 640-644, doi.org: 10.1016/j.talanta.2014.08.022. Hui Zhou, Zhe Qu, Valeri V. Mossine, Dineo L. Nknolise, Jilong Li, Zhenzhou Chen, Jianlin Cheng, C. Michael Greenlief, Thomas P. Mawhinney, Paula N. Brown, Kevin L. Fritsche, Mark Hannink, Dennis B. Lubahn, Grace Y. Sun, Zezong Gu, “Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells,” PLoS ONE, 2014,9 (11): e113531, doi: 10.1371/journal.pone.0113531. Ping Gong, Zeynep Madak-Erdogan, Jilong Li, Jianlin Cheng, C. Michael Greenlief, William G. Helferich, John A. Katzenellenbogen and Benita S. Katzenellenbogen, “Transcriptome Analyses Reveal Gene Networks Regulated by ERα and ERβ that Control Distinct Effects of Different Botanical Estrogens,” Nuclear Receptor Signaling, 2014 12: 1-13, doi:10.1621/nrs.12001. Jeremy Dahmen, Yongqiang Yang, C. Michael Greenlief, Gary Stacey, and Heather Hunt, “Interfacing whispering gallery mode optical microresonator biosensors with the plant defense elicitor chitin,” Colloids and Surfaces B: Biointerfaces, 2014, 122: 241-249, doi:10.1016/j.colsurfb.2014.06.067. Zhe Qu, Fanjun Meng, Ryan Bomgarden, Rosa, Viner, Jilong Li, John Rogers, Jianlin Cheng, C. Michael Greenlief, Jiankun Cui, Dennis Lubahn, Grace Sun, and Zezong Gu, “Proteomic Quantification And Site-Mapping of S-Nitrosylated Proteins Using Isobaric iodoTMT Reagents,” Journal of Proteome Research, 2014, 13: 3200-3211, doi: 10.1021/pr401179v. Zhe Qu, Fanjun Meng, Quanhui Wang, Fan Wei, Jilong Li, Jianlin Cheng, C. Michael Greenlief, Dennis B. Lubahn, Grace Y. Sun, Siqi Liu, and Zezong Gu, “NitroDIGE Analysis Reveals Inhibition of Protein S-Nitrosylation by Epigallocatechin Gallates in Lipopolysaccharide-stimulated Microglial Cells,” Journal of Neuroinflammation, 2014, 11:17, doi:10.1186/1742-2094-11-17.