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个人简介

1995年9月至1999年7月 西南师范大学化学化工学院获理学学士学位 1999年8月至2004年7月 中科院上海有机化学研究所获化学博士学位 2004年8月至2007年4月 美国犹他大学药学院博士后研究员 2007年4月至2008年8月 美国印第安纳大学医学院博士后研究员 2008年8月至2011年10月 美国马里兰大学药学院研究助理教授 2011年10月至今 武汉大学药学院教授、博士生导师

研究领域

单一分子量聚乙二醇修饰的多肽/蛋白药物 药物的氟-19可视化传输与缓释 含氟药物的合成与其在化学生物学中的应用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhang, H.; Li, Y.; Chen, S.; Yuan, Y.; Jiang, Z.-X.;* Zhou, X.* “129Xe hyper-CEST/19F MRI multimodal imaging system for sensitive tumor cells detection” ACS Appl. Bio Mater. 2019, 2, 27-32. 2. Zhu, J.; Xiao, Y.; Zhang, H.; Li, Y.; Yuan, Y.; Yang, Z.; Chen, S.; Zheng, X.; Zhou, X.; Jiang, Z.-X.* “Peptide monodisperse PEG “combs” with fine-tunable LCST and multiple imaging modalities” Biomacromolecules 2019, doi: 10.1021/acs.biomac.8b01693 3. Deng, T.; Mao, X.; Xiao, Y.; Yang, Z.; Zheng, X.; Jiang, Z.-X.* “Monodisperse oligoethylene glycols modified Camptothecin, 10-hydroxycamptothecin and SN38 prodrugs” Bioorg. Med. Chem. Lett. 2019, 29, 581-584. 4. Li, Y.; Wang, X.; Chen, Y.; Yang, Z.; Jiang, Z.-X.* “Monodisperse polyethylene glycols “brushes” with enhanced lipophilicity, thermos and plasma stability” Chem. Commun. 2019, 55, 1895-1898. 5. Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;* Yu, Y. B.* “Monitoring dendrimer conformational transition using 19F and 1H2O NMR” Magn. Reson. Chem. 2019, doi: 10.1002/mrc.4849. 6. Xue, D.; Wang, J.; Song, X.; Wang, W.; Ye, L.; Liu, Y.; Zhou, Q.; Jiang, Z.-X.; Liu Z.-J.; Tan, H.* “Chemical amphiphile replacement strategy for membrane protein research” Langmuir, 2019, doi: 10.1021/acs.langmuir.8b04072 7. Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Feng, Y.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;* Yu, Y. B.* “Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly” RSC Adv. 2019, 9, 1956-1966. 8. Liu, X.; Jiang, Z.-X.; Yu, B. Y.; Jeong, E.-K.* “Study of kinetics of 19F-MRI using a fluorinated imaging agent (19FIT) on a 3T clinical MRI system” Magn. Reson. Mater. Phys. Biol. Med. 2018, doi: 10.1007/s10334-018-0707-7 9. Lv, X.; Zheng, X.; Yang, Z.; Jiang, Z.-X.* “One-pot synthesis of monodisperse dual-functionalized polyethylene glycols through macrocyclic sulfates” Org. Biomol. Chem. 2018, 16, 8537-8545. 10. Jia, Y.; Chen, L.; Zhang, H.; Zheng, Y.; Jiang, Z.-X.; Yang, Z.* “Electrophilic chloro(ω-alkoxy) lation of alkene employing 1-chloro-1,2-benzoidoxol-3-one: facile synthesis of β-chloroethers” Org. Biomol. Chem. 2018, 16, 7203-7213. 11. Deng, T.; Mao, X.; Li, Y.; Bo, S.; Yang, Z.; Jiang, Z.-X.* “Monodisperse oligoethylene glycols modified Propofol prodrugs” Bioorg. Med. Chem. Lett. 2018, 28, 3502-3505. 12. Peng, Q.; Li, Y.; Bo, S.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “Paramagnetic nanoemulsions with unified signal for sensitive 19F MRI cell tracking” Chem. Commun. 2018, 54, 6000-6003. 13. Bo, S.; Yuan, Y.; Chen, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “In vivo drug tracking with 19F MRI at therapeutic dose” Chem. Commun. 2018, 54, 3875-3878. 14. Jia, Y.; Qin, H.; Wang, N.; Jiang, Z.-X.; Yang, Z.* “Fe2O3-promoted intermolecular chlorotrifluoro-methylthiolation of alkenes” J. Org. Chem. 2018, 83, 2808-2817. 15. Li, Y.; Shi, Q.; Shao, J.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Wen, S.; Jiang, Z.-X.* “Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives” Eur. J. Med. Chem. 2018, 148, 279-290. 16. Yu, Z.; Bo, S.; Wang, H.; Li, Y.; Yang, Z.; Huang, Y.; Jiang, Z.-X.* “Application of monodisperse PEGs in pharmaceutics: monodisperse polidocanols” Mol. Pharm. 2017, 14, 3473-3479. 17. Peng, Q.; Yuan, Y.; Zhang, H.; Bo, S.; Li, Y.; Chen, S.; Yang, Z.; Zhou, X.; Jiang, Z.-X.* “19F CEST imaging probes for metal ion detection” Org. Biomol. Chem. 2017, 15, 6441-6446. 18. Liu, X.; Yuan, Y.; Bo, S.; Li, Y.; Yang, Z.; Zhou, X.; Chen, S.*; Jiang, Z.-X.* “Monitoring fluorinated dendrimer-based self-assembled drug-delivery systems with 19F magnetic resonance” Eur. J. Org. Chem. 2017, 4461-4468. 19. Xing, H.; Chen, L.; Jia. Y.; Jiang, Z.-X.*; Yang, Z.* “Fe2O3-catalyzed Pummerer rearrangement of acyl chlorides and sulfoxides: facile synthesis of alkylthiomethyl ester” Tetrahedron Lett. 2017, 58, 2199-2202.

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