洪葵 - 武汉大学

个人简介

学习简历： 1984.9―1988.7 武汉大学生物系微生物专业学士学位 1988.9―1991.7 华南热带作物学院加工系热带作物产品发酵方向硕士学位 1995.9―1998.7 南京农业大学（清华大学）微生物学专业博士学位 1998.11-1999.7 香港理工大学应用生物与化学系 Research Associate 2000.7-2000.10 香港理工大学应用生物与化学系 Research Associate 2004.11-2005.11 获得英国皇家学会KC-WONG中国学者奖学金在英国Heriot Watt 大学 (Host by Grant Bergeys)和Newcatstle 大学（Host by Prof Michael Goodfellow）访问学习 UK Royal Society China Fellow 2009.6 获得英国政府资助访问普利茅斯海洋实验室 2013.7-2013.9 欧盟第七框架项目访问英国阿伯丁大学化学系海洋天然产物研究中心工作简历： 2010.12―现在武汉大学药学院教授 2006.9-2010.12 中国热带农业科学院热带生物技术研究所 PI 教授 2002.5―2006.9 中国热带农业科学院、华南热带农业大学热带作物生物技术国家重点实验室 PI，教授. 2000.4―2002.4 华南热带农业大学环境与植物保护学院副教授（高聘教授）. 1999.9―2000.4 中国热带农业科学院、华南热带农业大学科研处处长副教授（高聘教授） 1991.7―1999.9 华南热带作物学院加工系（华南热带农业大学工学院）助教、讲师、高聘副教授，工学院院长助理。

研究领域

要从事海洋微生物新药发现研究。应用基因组测序及沉默基因激活、生物勘探、宏基因组、选择性分离、结构导向分离等技术，在采样生态、菌种类型、化合物类型、生物活性评价等层面采用目标导向的策略，收集高质量红树林微生物资源5000多份，菌种类群包括具有高活性天然产物合成能力的青霉和曲霉等真菌以及链霉菌、小单孢菌、疣孢菌、游动放线菌、小双孢菌、野野村菌等放线菌。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Chai H, Yin R, Liu Y, Meng H, Zhou X, Zhou G, Bi X, Yang X, Zhu T, Zhu W, Deng Z, Hong K*. Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus. Sci Rep. 2016Jun 7; 6:27181. doi: 10.1038/srep27181. 2. Zhang L, Ruan C, Peng F, Deng Z, Hong K*. Streptomyces arcticus sp. nov., isolated from the Arctic. Int J Syst Evol Microbiol. 2016 Jan 19. doi: 10.1099/ijsem.0.000907. [Epub ahead of print] 3. Xie QY, Ren J, Li L, Li Y, Deng ZX, Hong K*. Micromonospora mangrovi sp. nov., isolated from mangrove soil. Antonie Van Leeuwenhoek. 2016 Apr;109(4):483-91. doi: 10.1007/s10482-015-0641-x. Epub 2016 Mar 4 4. Mostafa E. Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher M. Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, Mervin Bibb, Kwaku Kyeremeh, Pieter C. Dorrestein, Kui Hong,* Marcel Jaspars*, Hai Deng*.Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate. Organic & Biomolecular Chemistry, 2015. DOI: 10.1039/c5ob01269d 5. Xu D, Ma M, Liu Y, Zhou T, Wang K, Deng Z, Hong K*. PreQ0 base, an unusualmetabolite with anti-cancer activity from Streptomyces qinglanensis 172205. Anticancer Agents Med Chem. 2015;15(3):285-90. 6. Xu DB, Ma M, Deng ZX, Hong K*. Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205. Appl Microbiol Biotechnol. 2015 Jul; 99(14):5825-32. doi: 10.1007/s00253-015-6574-5. Epub 2015 Apr 17 7. Yin Zhai, Bin Cheng, Juan Hu, Kwaku Kyeremeh, Xiaoling Wang, Marcel Jaspars, Hai Deng, Zi-Xin Deng, Kui Hong*, Draft genome sequence of Streptomyces sp. strain CT34, isolated from a Ghanaian soil sample, Genome announcements, 2015 Feb 5;3(1). pii: e01508-14. doi: 10.1128/genomeA.01508-14 8. Lv C, Qin W, Zhu T, Wei S, Hong K*, Zhu W, Chen R, Huang C. Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signaling. Mar Drugs. 2015 Jan 16;13(1):431-43. doi: 10.3390/md13010431. 9. Xu DB, Ye WW, Han Y, Deng ZX, Hong K*. Natural Products from Ma, ngrove Actinomycetes. Marine Drugs. 2014, 12, 2590-2613; doi:10.3390/md12052590 10. Sun W, Lv C, Zhu T, Yang X, Wei S, Sun J, Hong K*, Zhu W*, Huang C*. Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells. Marine Drugs. 2013; 11:4570-4584. 11. Yuan GJ, Hong K*, Lin HP, She ZG, Li J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Marine Drugs. 2013, 11, 817-829 12. Li T , Du YY , Cui Q , Zhang JT, Zhu W, Hong K*, Li WL*. Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA, Marine Drugs. 2013，11, 466-488, 13. Fu P, Yang Cl, Wang Y, Liu PP, Ma YM, Xu L, Su MB, Hong K,* and Zhu WM *. Streptocarbazoles A and B, Two Novel 2 Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp. FMA. Organic Letters. 2012，14 (9): 2422–2425 14. Yang TT, Lu ZY, Meng L, Wei SJ, Hong K*, Zhu WM *, Huang CG *. The Novel Agent Ophiobolin O Induces Apoptosis and Cell Cycle Arrest of MCF-7 Cells Through Activation of MAPK Signaling Pathways. Bioorganic & Medicinal Chemistry Letters. 2012. 22:579–585 15. Hu H, Lin HP, Xie QY, Li L, Xie XQ, Hong K*. Streptomyces qinglanensis sp. nov., Isolated from Mangrove Sediment. International Journal of Systematic and Evolutionary Microbiology. 2012，62: 596–600. 16. Xie QY, Hong K*, Goodfelllow M. Genus-specific Primers Targeting the 16S rRNA Gene for PCR Detection of Members of the Genus Verrucosispora. Antonie van Leeuwenhoek. 2011, 100:117-128; 17. Xie QY, Wang C, Wang R, Qu Z, Lin HP, Goodfellow M, and Hong K*，Jishengella endophytica gen. nov., sp. nov., a New Member of the Family Micromonosporaceae，International Journal of Systematic and Evolutionary Microbiology. 2011, 61, 1153–1159. 18. Chen GD, Gao H, Tang JS, Huang YF, Chen Y, Wang Y, Zhao HN, Lin HP, Xie QY, Hong K, Li J, Yao XS*. Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp. (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in vitro. Chemistry Pharmacy Bullitin. 2011, 59: 447—451. 19. Wang C, Xu XX, Qu Z, Wang HL, Lin HP, Xie QY, Ruan JS and Hong K *，Micromonospora rhizosphaerae sp. nov., Isolated from Mangrove Rhizosphere Soil. International Journal of Systematic and Evolutionary Microbiology. 2011 61, 320–324. 20. Yuan GJ, Lin HP, Wang C, Hong K*, Liu Y, Li J. The 1H and 13C Resonance of Two New Macrocyclic Lactones Isolated from Streptomyces sp. 211726 and Revised Assignments of Azalomycins F3a, F4a and F5a. Magnetic resonance in chemistry. 2011, 49, 30–37.