苏畅 - 武汉大学 - 生命科学学院

个人简介

学习经历 2003－2009　中科院上海生命科学研究院生物化学与细胞生物学研究所，博士 1999－2003　南开大学生物科学专业，学士工作经历与任职 2016－至今　武汉大学生命科学学院，副研究员 2015－2016　加州大学欧文分校医学院，研究助理 2010－2015　加州大学欧文分校医学院，博士后

研究领域

1）白念珠菌在宿主体内的营养代谢调控其形态发生和致病性的分子机制；2）病原真菌的社会性参与调控毒力、抗药性以及发育分化的机理；3）白念珠菌如何通过与肠道菌群的相互作用促进其在体内的生长繁殖以及毒力发挥。通过对病原真菌致病机理的研究，以期找到新的药物靶点来有效对抗真菌的系统性感染。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Chang Su*, Yang Lu*, and Haoping Liu. (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi，Nature Communications，2016.10.03，7 (* equal contribution) 2. Yang Lu, Chang Su, and Haoping Liu. (2014) Candida albicans hyphal initiation and elongation. Trends in Microbiology 22(12): 707-14. 3. Yang Lu*, Chang Su*, Ohimai Unoje, and Haoping Liu. (2014) Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. PNAS 111(5): 1975-80. (* equal contribution) 4. Yang Lu, Chang Su, Norma V. Solis, Scott G. Filler, and Haoping Liu. (2013) Synergistic regulation of hyphal elongation by hypoxia, CO2, and nutrient conditions controls the virulence of Candida albicans. Cell Host & Microbe 14(5): 499-509. 5. Chang Su*, Yang Lu*, and Haoping Liu. (2013) Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity. Molecular Biology of the Cell 24(3): 385-97. (* equal contribution) 6. Yang Lu, Chang Su, and Haoping Liu. (2012) A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans. PLoS Pathogens 8(4): e1002663. 7. Yang Lu, Chang Su, Allen Wang, and Haoping Liu. (2011) Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance. PLoS Biology 9(7): e1001105. 8. Chang Su, Yandong Li, Yang Lu, and Jiangye Chen. (2009) Mss11, a transcriptional activator, is required for hyphal development in Candida albicans. Eukaryotic Cell 8(11):1780-91. 9. Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu, and Jiangye Chen. (2008) Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Molecular Biology of the Cell 19(10): 4260-72. 10. Yandong Li, Chang Su, Xuming Mao, Fang Cao, and Jiangye Chen. (2007) Roles of Candida albicans Sfl1 in hyphal development. Eukaryotic Cell 6(11): 2112-21.