个人简介
学习经历: 2004-2005: 在加拿大西安大略大学做访问学者 1995-1998: 在武汉大学生命科学院病毒系攻读博士学位 专业方向:分子病毒学 1984-1985: 在中国科学院(北京)植物研究所学习 专业方向:植物细胞与组织培养 1979-1983: 在武汉大学生物系读大学 专业方向:细胞生物学 主要工作经历与任职情况: 2005.2 –至今: 武汉大学生命科学学院生物技术系教授。博士生导师。 2004.2–2005.1: 加拿大西安大略大学生物化学系(博士后) 2000.1-2004.12:武汉大学生命科学学院副教授,硕士生导师,武汉大学校纳米科学与技术工程研究中心生物芯片专项的主持者,校科学仪器工程中心骨干成员。 1998-2000: 武汉大学(生命科学院)氨基酸研究所副所长,湖北省氨基酸产业化工程中心副主任,武大弘元公司技术负责人。 1985-1993: 西藏高原生物研究所实习研究员、助理研究员.西藏生物资源研究开发中心经理;西藏诺迪奥实业有限公司总工程师。
研究领域
近年来致力于生物医药产品及病毒的分子诊断与治疗技术研究。生物医药产品研发方面主要开展了枯草杆菌溶栓酶肠溶胶囊和抗病毒贴剂方面的研究;分子诊断技术方面建立了包括基因芯片、蛋白质芯片、荧光定量基因检测和金标层析试纸条快速检测等技术平台,特别是在基于生物信号纳米放大技术的基因高效检测技术研究方面形成了特色;治疗技术方面,开展了病毒亲和吸附柱研究。
近期论文
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1.Qiang Ma,Youyun Zhao,Yefu Wang*, Comprehensive Analysis of the Prevalence of Hepatitis B Virus Escape Mutations in the Major Hydrophilic Region of Surface Antigen. Journal of Medical Virology 84:198–206(2012). 2.Youyun Zhao,Yefu Wang*,et al, A novel multiplex real-time PCR assay for the detection and quantification of HPV16/18 and HSV1/2 in cervical cancer screening. Molecular and Cellular Probes, 2012,26:66-72. (第一作者,SCI, IF=2.373 ). 3.Youyun Zhao,Yefu Wang*,et al, Relationship between Cervical Disease and Infection with Human Papillomavirus Types 16 and 18, and Herpes Simplex Virus 1 and 2. Journal of medical virology, Accepted, In Production. 4.Jingfeng Tang,Li Zhou,Lian Lian Duan,Yang Feng,Xuan Cao,Yefu Wang*, Development and evaluation of a new detection tool—visual DNA microarray for simultaneous and specific detection of human immunode?ciency virus type-1 and hepatitis C virus,Mol Biol Rep,Accepted: 18 February 2011,Online 26 February 2011. 5.Li Zhou, Jingfeng Tang, Youyun Zhao, Rui Gong, Xuan Lu, Lulu Gong,Yefu Wang*,A highly sensitive TaqMan real-time PCR assay for early detection of Schistosoma species,Acta Tropica 120 (2011) 88–94 6.Jingfeng Tang, Li Zhou, Xiaoying Liu, Changming Zhang, Youyun Zhao, Yefu Wang*,Novel multiplex real-time PCR system using the SNP technology for the simultaneous diagnosis of Chlamydia trachomatis, Ureaplasma parvum and Ureaplasma urealyticum and genetic typing of serovars,of C. trachomatis and U. parvum in NGU,Molecular and Cellular Probes 25 (2011) 55——59 7.Jingfeng Tang, Zhenghui Xu, Li Zhou, Hong Qin, Yefu Wang,Rapid and simultaneous detection of Ureaplasma parvum and Chlamydia trachomatis antibodies based on visual protein microarray using gold nanoparticles and silver enhancement,Diagnostic Microbiology and Infectious Disease 67 (2010) 122 –128 8.Jinbiao Lu*, Dong Wei, Yefu Wang* and Guozhi Wang,High-level expression and single-step purification of recombinant Bacillus anthracis protective antigen from Escherichia coli。Biotechnology and Applied Biochemistry, 2009, 52:107–112. 9.Jingfeng Tang, Li Zhou, Wenjuan Gao, Xuan Cao, Yefu Wang*, Visual DNA microarrays for simultaneous detection of human immunodeficiency virus type-1 and Treponema pallidum coupled with multiplex asymmetric polymerase chain reaction, Diagnostic Microbiology and Infectious Disease, 2009, 65:372-378. 10.Chengjun Li, Brian Chung, Jianping Tao, Cristiana Iosef, Ala Aoukaty, Yefu Wang, Rusung Tan and Shawn Shun-Cheng Li,The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcγRIIB receptor,Cellular Signalling,2008, Volume 20 ,Issue 11 ,Pages 1960 – 1967. 11.Zhang Yeqin Yefu Wang* and Jiang Xiaodi,The application of nano-particles in biochip, Recent Patents on Biotechnology, 2008,2,55-59