个人简介

Chung F. Wong received his B.Sc. (Hons.) degree from the Chinese University of Hong Kong and his Ph.D. degree from the University of Chicago. He did his postdoctoral work at the University of Houston. He held academic and industrial positions at the University of Houston, Mount Sinai School of Medicine, SUGEN, Inc., University of California-San Diego, and the Howard Hughes Medical Institute before joining the faculty of UM-St. Louis in 2004.

研究领域

Computational, Physical, Biochemistry

Our research involves the development and applications of computational methods to study biomolecular structure, dynamics, and function and to aid the design of bioactive compounds. For details please go to the link above to the laboratory homepage.

近期论文

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C.F. Wong, "Incorporating Drug-Binding Kinetics in Drug Design" in: "In Silico Drug Discovery and Design: Theory, Methods, Challenges and Applications" C.N. Cavasotto (Ed.), CRC Press; in press. T. Shen & C.F. Wong, “Brownian Dynamics Simulation of Peptides with the University of Houston Brownian Dynamics (UHBD) Program”, Methods in Molecular Biology, in press. M.P. Paudyal, L. Wu, Z.-Y. Zhang, C.D. Spilling & C.F. Wong, "A New Class of Salicylic Acid Derivatives for Inhibiting YopH of Yersinia pestis", Bioorg. Med. Chem., in press. C.F. Wong, "Molecular Simulation of Drug-Binding Kinetics", Molecular Simulation, in press. P.M. Gontarz, J. Berger & C.F. Wong, "SRmapper: A Fast and Sensitive Genome-Hashing Alignment Tool", Bioinformatics, 29 (2013) 316. C.F. Wong & S. Bairy, "Drug Design for Protein Kinases and Phosphatases: Flexible-Receptor Docking, Binding Affinity and Specificity, and Drug-Binding Kinetics", Current Pharmaceutical Design, 19 (2013) 4739. Z. Huang & C.F. Wong, “Simulation Reveals Two Major Docking Pathways between the Hexapeptide GDYMNM and the Catalytic Domain of the Insulin Receptor Protein Kinase", Proteins: Structure, Function, and Bioinformatics, 80 (2012) 2275. Z. Huang & C.F. Wong, “A Case Study of Scoring and Rescoring in Peptide Docking”, Methods in Molecular Biology, 819 (2012) 269-93. S. Bairy & C. F. Wong, “Influence of Kinetics of Drug Binding on EGFR Signaling: A Comparative Study of Three EGFR Signaling Pathway Models”, Proteins: Structure, Function, Bioinformatics, 79 (2011) 2491–2504. Z. Huang & C.F. Wong, “Incorporating Protein Flexibility in Molecular Docking by Molecular Dynamics: Applications to Protein Kinase and Phosphatase Systems” in “Computational Studies of New Materials II: From Ultrafast Processes and Nanostructures to Optoelectronics, Energy Storage and Nanomedicine”, T.F. George, D. Jelski, R.R. Letfullin, G. Zhang (Eds.), World Scientific, Singapore, London (2011) pp. 219-250. J. Shi, Z. Lu, Q. Zhang, M. Wang, C.F. Wong & J. Liu, "Supplementing the PBSA approach with quantum mechanics to study the binding between CDK2 and N2-substituted O6-cyclohexylmethoxyguanine inhibitors", J. Theor. Comput. Chem., 9 (2010) 543. Z. Huang, Y. He, X. Zhang, A. Gunawan, L. Wu, Z.-Y. Zhang & C. F. Wong, "Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis", Chem. Biol. Drug Design, 76 (2010) 85-99. Z. Huang & C.F. Wong, "Docking Flexible Peptide to Flexible Protein by Molecular Dynamics Using Two Implicit-Solvent Models: An Evaluation in Protein Kinase and Phosphatase Systems", J. Phys. Chem. B, 113 (2009) 14343-14354. M. Goyal, M. Rizzo, F. Schumacher & C.F. Wong, "Beyond Thermodynamics: Drug Binding Kinetics Could Influence Epidermal Growth Factor Signaling", J. Med. Chem., 52 (2009) 5582-5585. B. Zhou & C.F. Wong, "A Computational Study of the Phosphorylation Mechansim of the Insulin Receptor Tyrosine Kinase", J. Phys. Chem. A, 30 (2009) 5144-5150. Z. Huang & C.F. Wong, "Conformational Selection of Protein Kinase A Revealed by Flexible-Ligand Flexible-Protein Docking", J. Comput. Chem. 30 (2009) 631-644. B. Zhou, M. Agarwal & C.F. Wong, “Variable Atomic Radii for Continuum-Solvent Electrostatics Calculation”, J. Chem. Phys. 129 (2008) 014509. C.F. Wong, “Flexible Ligand-Flexible Protein Docking in Protein Kinase Systems”, Biochim Biophys Acta., 1784 (2008) 244-251. Z. Huang, C.F. Wong & R. Wheeler, "Flexible Protein-Flexible Ligand Docking with Disrupted Velocity Simulated Annealing", Proteins: Structure, Function, Bioinformatics, 7 (2008) 440-454. Z. Huang & C.F. Wong, "A Mining-Minima Approach to Exploring the Docking Pathways of p-Nitrocatechol Sulfate to YopH", Biophys. J., 83 (2007) 4141-4150.