刘青珍 - 武汉大学 - 生命科学学院

个人简介

教学工作： 1. 分子生物学（英语教学，主讲），本科生课程，2005年至今 2. 基因工程（独立主讲），本科生课程，2006春季 3. 病毒与生命（联合主讲），本科生通识课程，2005年至今 4. 分子病毒学（主讲），研究生课程，2009年至今 5. 高级微生物学（联合主讲），研究生课程，2009年至今

研究领域

1.细胞凋亡相关因子的功能； 2.病毒蛋白与宿主因子的相互作用

近期论文

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1.Deng Z, Yan H, Hu J, Zhang S, Peng P, Liu Q* and Guo D*: Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. 2012, PLoS One 7: e37700. 2. Onsam Sin, Prudence Mabiala, Ye Liu, Ying Sun, Tao Hu, Qingzhen Liu* and Deyin Guo. Gene silencing efficiencies and INF-β induction effects of splicing miRNA 155-based artificial miRNA with different pre-miRNA stem-loop structures. Biochemical Genetics. 2012, 50 (1-2):112-21. 3. Qingzhen Liu and Rollie Clem*. Defining the core apoptosis pathway in the mosquito disease vector Aedes aegypti: the roles of iap1, ark, dronc, and effector caspases. Apoptosis. 2011, 16(2):105-13. 4. Yang W, Qu S, Liu Q*, Zheng C*. Avian influenza virus A/chicken/Hubei/489/ 2004 (H5N1) induces caspase-dependent apoptosis in a cell-specific manner. Mol Cell Biochem. 2009, 332(1-2):233-41. 5. Qingzhen Liu* and Nor Chejanovsky*. Activation pathways and signal-mediated up-regulation of the insect Spodoptera frugiperda caspase-1. Apoptosis 2006, 11(4):487-96. 6. Qingzhen Liu, Yipeng Qi and Nor Chejanovsky*. Spodoptera littoralis caspase-1, a Lepidopteron effector caspase inducible by apoptotic signaling. Apoptosis 2005, 10:787-795. 7. Qingzhen Liu, Yipeng Qi, Nor, Chejanovsky. Identification and Classification of the Spodoptera littoralis Nucleopolyhedrovirus Inhibitor of Apoptosis Gene. Virus Genes 2003, 26(2): 143-149. 8. Bryant B, Ungerer MC, Liu Q, Waterhouse RM, Clem RJ*. A caspase-like decoy molecule enhances the activity of a paralogous caspase in the yellow fever mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2010, 40(7):516-23. 9. Li J, Ishaq M, Prudence M, Xi X, Hu T, Liu Q, Guo D. Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2. Virus Res. 2009, 144(1-2):123-9. 10. Wu X, Zhou Y, Zhang K, Liu Q, Guo D. Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Lett. 2008, 582(15):2155-60. 11. Ishaq M, Hu J, Wu X, Fu Q, Yang Y, Liu Q, Guo D. Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Mol Biotechnol. 2008, 39(3):231-8. 12. Li J, Cai H, Liu Q, Guo D. Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus Genes. 2008, 37(1): 88-95. 13. Chen P, Jiang M, Hu T, Liu Q, Chen XS, Guo D. Biochemical characterization of exoribonuclease encoded by SARS coronavirus. J Biochem Mol Biol. 2007, 40(5): 649-55. 14. Kuang E, Wan Q, Li X, Xu H, Liu Q, Qi Y. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). J Cell Physiol. 2005: 204(2): 549-59. 15. Gan Miao, Liu Qing-Zhen, Qi Yi-Peng, Qi Bing. Polymerization of HAP hydrophobic regions and its relation with apoptosis. Chinese Journal of Biochemistry and Molecular Biology 2004, 20 (2): 117-124. (Co-first author). 16. Gan M, Qi Y, Wan Q, Kuang E, Liu Q, Liu X. Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death. Mol Biol Rep. 2004, 31(3): 159-64.