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个人简介

教育经历/Education: 1989-1994 重庆医科大学临床医学专业,获医学学士学位 1995-1998 重庆医科大学病理生理学专业,获医学硕士学位 1998-2001 中南大学湘雅医学院病理生理学专业,获医学博士学位 工作经历与任职/Professional Experience: 1994-1995 四川省屏山县人民医院,住院医师 2002-2006 美国宾夕法尼亚大学医学院,博士后 2006-2016 中国科学院上海巴斯德研究所研究员,博士生导师,肿瘤病毒研究组组长,病原诊断技术研发中心主任 2011-2016 中国科学院上海巴斯德研究所副所长,纪委书记 2017-至今 武汉大学病毒学国家重点实验室主任,武汉大学医学研究院副院长,生命科学学院教授、博士生导师

研究领域

主要从事肿瘤疱疹病毒感染及致瘤机理研究,在卡波氏肉瘤疱疹病毒(KSHV)潜伏感染与致瘤机理研究方面做出了系统性、原创性的研究工作:曾揭示KSHV关键开关分子RTA的表达调控机机理,提出RTA-LANA负反馈调控工作模型,得到领域内的广泛认可,对阐明KSHV潜伏感染的形成机制有重要的指导意义;曾利用KSHV作为工作模型,率先发现病毒包装自身及宿主miRNA,不仅揭示了病毒粒子一种新的构成成分,也鉴定了胞外游离型miRNA的一种新的存在形式,具有重要的学术价值;曾阐明KSHV通过操控Notch及BMP等重要信号转导通路参与致瘤的新机制,为发展相关肿瘤有效的治疗手段奠定了重要基础。

近期论文

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1. Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM, Dong YH, Lan K*. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 Aug 10;14(8):e1007232 2. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 2018 Jan;67(1):56-70. 3. Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog. 2017 Sep 28;13(9):e1006580. 4. Zou Z, Meng Z, Ma C, Liang D, Sun R, Lan K*. Guanylate-binding protein 1 inhibits nuclear delivery of Kaposi's sarcoma-associated herpesvirus virions by disrupting formation of actin filament. J Virol. 2017 Jul 27;91(16). pii: e00632-17 5. Lin X, Sun R, Zhang F, Gao Y, Bin L, Lan K*. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/sentrin Specific Peptidase 6 to Facilitate Latency Establishment. J Virol. 2017 Aug 10;91(17). pii: e00806-17 6. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. PLoS Pathog. 2017 Jan 24;13(1):e1006167 7. Li S, Hu H, He Z, Liang D, Sun R, Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct 19;12(10):e1005900 8. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*. Genome-wide mapping of the binding sites and structural analysis of KSHV vIRF2 reveal it is a DNA-binding transcription factor. J Virol. 2015 Nov 4;90(3):1158-68 9. Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*. Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7. J Virol. 2015 Feb 15;89(4):2041-51. 10. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 2015 Jan;89(1):415-27 11. Hu H, Zhang H, Gao Z, Wang D, Liu G, Xu J, Lan K*, Dong Y*. Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting. Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2175-85 12. Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S, Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis. PLoS Pathog. 2014 Jul 10;10(7):e1004253. 13. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y, Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice. J Virol. 2014 Jul;88(14):8045-56 14. Sun R, Liang D, Gao Y, Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency. J Virol. 2014 Jul 1;88(13):7331-7344. 15. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q, Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014 Jun;88(11):6506-11 16. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1. Cancer Res. 2014 Apr 1;74(7):2026-37. 17. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection. J Virol. 2014 Mar;88(5):3004-15. 18. Han J, Jin M, Zhang P, Liu J, Wang L, Wen D, Wu X, Liu G, Zou Y, Lv X, Dong X, Shao B, Gu S, Zhou D, Leng Q, Zhang C, Lan K. Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill. 2013 May 16;18(20). pii: 20481. 19. Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q, Lan K*. Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses. Emerg Microbes Infect. 2013 May;2(5):e23.

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