曹志贱 - 武汉大学 - 生命科学学院

个人简介

教育经历/Education： 1999/09-2004/06，武汉大学，博士/Wuhan University, PhD 1994/09-1998/07，武汉大学，学士/Wuhan University, Bachelor's Degree 工作经历/Professional Experience： 2004/07-至今：武汉大学生命科学学院/College of Life Sciences, Wuhan University 2014/02-2015/01：美国梅哈里医学院/Meharry Medical College, USA 1998/07-1999/08：湖南省畜牧兽医研究所/Animal husbandry and veterinary institute of Hunan province

研究领域

研究方向/Research Fields： 1) 病毒感染及其防治/Viral infection, prevention and cure 2) 抗病原微生物多肽的药用基础/Medicinal basis of peptides against pathogen viruses and bacteria 3) 毒素多肽生物学/Toxic peptide biology

近期论文

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1) Song Y, Gong K, Yan H, Hong W, Wang L, Wu YL, Li WH*, Li WX*, Cao ZJ*. (2014). Sj7170, a unique dual-functional peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor activating effect from scorpion venom. J Biol Chem.289(17):11667-80. 2) Cao Z#, Yu Y#, Wu Y#, Hao P#, Di Z#, He Y#, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W. (2013). The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun. 4:2602. 3) Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z*. (2013). Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 34(13):3511-3522. 4) He Y, Zhao R, Di Z, Li Z, Xu X, Hong W, Wu Y, Zhao H, Li W, Cao Z*. (2013). Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae. J Proteomics. 89:1-14. 5) Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W*, Cao Z*. (2012). Mucroporin-M1 inhibits Hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) Pathway and down-regulating HNF4α in vitro and in vivo. J Biol Chem.287(36):30181-30190. 6) Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W*, Cao Z*. (2011). Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother. 55(11):5220-5229. 7) Yu XF, Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu Y, Cao Z*, Li W*. (2010). Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials. 31(33): 8724-8731. 8) Di Z, Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X*, Li W*, Cao Z*. Genome-wide analysis of homeobox genes from Mesobuthus martensii reveals Hox gene duplication in scorpions. Insect Biochem Mol Biol. 2015 Jun;61:25-33. 9) Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z*. Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antiviral Res. 102:1-10, 2014. 10) Ma Y, He Y, Zhao R, Wu Y, Li W*, Cao Z*. Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: Implication for proteome evolution of scorpion venom arsenal. J Proteomics. 75(5):1563-1576, 2012. 11) Zhao R, Ma Y, He Y, Di Z, Wu Y, Cao Z*, Li W*. Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 11: 452, 2010. 12) Ma Y, Zhao Y, Zhao R, Zhang W, He Y, Wu Y, Cao Z*, Guo L*, Li W*. Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis. Proteomics. 10(13):2471-2485, 2010. 13) Li Z, Xu X, Meng L, Zhang Q, Cao L, Li W, Wu Y, Cao Z*. Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. PLoS One. 9(5):e97539, 2014. 14) Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D,Cao Z*, Yan H*. Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. PLoS One. 7(4):e34947, 2012. 15) Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z*, Li W*. Antibacterial activity and mechanism of a scorpion venom Peptide derivative in vitro and in vivo. PLoS One. 7(7):e40135, 2012. 16) Zhao R, Dai H, Qiu S, Li T, He Y, Ma Y, Chen Z, Wu Y, Li W*, Cao Z*. SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. PLoS One. 6(11):e27548, 2011. 17) Cao Z#, Di Z, Wu Y, Li W. Overview of scorpion species from China and their toxins. Toxins (Basel). 6(3):796-815, 2014. 18) Cao L, Li Z, Zhang R, Wu Y, Li W, Cao Z*. StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus. Peptides. 36(2):213-220, 2012. 19) Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z*, Zheng C*, Li W*. A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV. Peptides. 32: 11-19, 2011. 20) Yuan W, Cao L, Ma Y, Mao P, Wang W, Zhao R, Wu Y, Cao Z*, Li W*. Cloning and functional characterization of a new antimicrobial peptide gene StCT1 from the venom of the scorpion Scorpiops tibetanus. Peptides. 31(1):22-26, 2010. 21) Chen Z, Hu Y, Han S, Yin S, He Y, Wu Y, Cao Z* Li W*. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure.J Biochem Mol Toxicol. 25(4):244-251, 2011.