唐兵 - 武汉大学 - 生命科学学院

个人简介

学习经历： 1985.9-1989.6：武汉大学生物系微生物专业学士 1989.9-1992.6：武汉大学生物系微生物专业硕士 1992.9-1995.6：中国科学院微生物研究所酶室生物化学专业博士主要工作经历与任职情况： 1995.7-1997.9：武汉大学生命科学学院讲师 1997.10-2003.10：武汉大学生命科学学院副教授 2000.9-2002.9：日本国立食品研究所酶室博士后 2003.10-现在：武汉大学生命科学学院教授、博士生导师 2003-2006：生物技术系副主任 2006-2015：微生物系主任 2010-现在：生科院副院长

研究领域

极端（嗜热、嗜盐等）微生物酶结构与功能、适应机理及定向分子进化；极端古菌蛋白质组及其噬菌体分子遗传学；微生物基因及酶资源开发和应用。

近期论文

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1.Zhu F,Yang X, Wu Y, Wang Y, Tang XF, Tang B* (2017) Release of an HtrA-likeprotease from the cell surface of thermophilic Brevibacillus sp.WF146 via substrate-induced autoprocessing of the N-terminal membrane anchor.Front Microbiol 8:481. doi: 10.3389/fmicb.2017.00481. 2. Gao X,Zeng J, Yi H, Zhang F, Tang B*, Tang XF* (2017) Four inserts within thecatalytic domain confer extra stability and activity to hyperthermostablepyrolysin from Pyrococcus furiosus. Appl Environ Microbiol 83(5).pii:e03228-16. 3. Liu F,Zhao ZS, Ren Y, Cheng G, Tang XF, Tang B* (2016) Autocatalytic activationof a thermostable glutamyl endopeptidase capable of hydrolyzing proteins athigh temperatures. Appl Microbiol Biotechnol 100(24):10429-10441. 4. Tang W,Wu Y, Li M, Wang J, Mei S, Tang B*, Tang XF* (2016) Alternativetranslation initiation of a haloarchaeal serine protease transcript containingtwo in-frame start codons. J Bacteriol 198(13):1892-901. (Spotlightarticle) 5. Meng D,Dai M, Xu BL, Zhao ZS, Liang X, Wang M, Tang XF, Tang B* (2016) Maturationof fibrinolytic bacillopeptidase F involves both hetero- and autocatalyticprocesses. Appl Environ Microbiol 82(1):318-27. 6. Xu BL,Dai M, Chen Y, Meng D, Wang Y, Fang N, Tang XF, Tang B* (2015) Improvingthe thermostability and activity of a thermophilic subtilase by incorporatingstructural elements of its psychrophilic counterpart. Appl EnvironMicrobiol 81(18):6302-13. 7. Wang L,Cheng G, Ren Y, Dai Z, Zhao ZS, Liu F, Li S, Wei Y, Xiong J, Tang XF, TangB* (2015) Degradation of intact chicken feathers byThermoactinomyces sp.CDF and characterization of its keratinolytic protease. Appl MicrobiolBiotechnol 99(9): 3949-59. 8. Du X,Li M, Tang W, Zhang Y, Zhang L, Wang J, Li T, Tang B, Tang XF* (2015)Secretion of Tat-dependent halolysin SptA capable of autocatalytic activationand its relation to haloarchaeal growth. Mol Microbiol. 96(3):548-65. 9. ZhangY, Wang M, Du X, Tang W, Zhang L, Li M, Wang J, Tang B, Tang XF* (2014)Chitin accelerates activation of a novel haloarchaeal serine protease thatdeproteinizes chitin-containing biomass. Appl EnvironMicrobiol 80(18):5698-708. 10. ZengJ, Gao X, Dai Z, Tang B, Tang XF* (2014) Effects of metal ions onstability and activity of hyperthermophilic pyrolysin and further stabilizationof this enzyme by modiﬁcation of a Ca2+-binding site. ApplEnviron Microbiol 80(9):2763-72. 11. FengJ, Wang J, Zhang Y, Du X, Xu Z, Wu Y, Tang W, Li M, Tang B, Tang XF*(2014) Proteomic analysis of the secretome of haloarchaeonNatrinema sp. J7−2. JProteome Res 13(3):1248-58 12. Zhu H,Xu BL, Liang X, Yang YR, Tang XF, Tang B* (2013) Molecular basis for auto-and hetero-catalytic maturation of a thermostable subtilase from thermophilicBacillus sp.WF146. J Biol Chem 288(48):34826-38 13. FengJ, Liu B, Zhang Z, Ren Y, Li Y, Gan F, Huang Y, Chen X, Shen P, WangL, Tang B*, Tang XF* (2012) The complete genome sequenceofNatrinema sp. J7-2, a haloarchaeon capable of growth on synthetic mediawithout amino acid supplements. PLoS ONE 7(7): e41621.doi:10.1371/journal.pone.0041621 14. Dai Z,Fu H, Zhang Y, Zeng J, Tang B, Tang XF* (2012) Insights into thematuration of hyperthermophilic pyrolysin and the roles of its N-terminalpropeptide and long C-terminal extension. Appl EnvironMicrobiol 78(12):4233-4241 15. Xu Z,Du X, Li T, Gan F, Tang B, Tang XF* (2011) Functional insight into theC-terminal extension of halolysin SptA from haloarchaeonNatrinema sp.J7. PLoS ONE 6(8): e23562. doi:10.1371/journal.pone.0023562 16. LiangX, Bian Y, Tang XF, Xiao G, Tang B* (2010) Enhancement of keratinolyticactivity of a thermophilic subtilase by improving its autolysis resistance andthermostability under reducing conditions. Appl MicrobiolBiotechnol. 87(3):999-1006 17. FangN, Zhong CQ, Liang X, Tang XF, Tang B* (2010) Improvement of extracellularproduction of a thermophilic subtilase expressed inEscherichia coli byrandom mutagenesis of its N-terminal propeptide. Appl MicrobiolBiotechnol. 85(5):1473-1481. 18. ZhongCQ, Song S, Fang N, Liang X, Zhu H, Tang XF, Tang B* (2009) Improvement oflow-temperature caseinolytic activity of a thermophilic subtilase by directedevolution and site-directed mutagenesis. BiotechnolBioeng 104(5):862-70.(Spotlight article)