高向东 - 武汉大学 - 生命科学学院

个人简介

学习经历 1987-1992 中国科学技术大学生物系，学士 1992-1995 中国科学技术大学生物系，硕士 1995-1998 复旦大学遗传学研究所，博士主要工作经历与任职情况： 1998-1999 美国佛蒙特大学（University of Vermont）医学院，博士后 1999-2006 美国宾夕法尼亚大学（University of Pennsylvania）医学院，博士后/研究助理 2006-至今武汉大学生命科学学院，教授 2015- 微生物学系系主任

研究领域

1. 酿酒酵母出芽过程的调控 2．解脂耶氏酵母菌丝形成的调控

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Nie W-C, He F, Yuan S-M, Jia Z-W, Wang R-R, Gao X-D* (2017) Roles of an N-terminal coiled-coil-containing domain in the localization and function of Bem3, a Rho GTPase-activating protein in budding yeast. Fungal Genet. Biol. 99: 40-51. 2. Liang S-H, Wu H, Wang R-R, Wang Q, Shu T, Gao X-D* (2017) The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica. Mol. Microbiol. 104(4):553-567. 3. Yuan S-M, Nie W-C, He F, Jia Z-W, Gao X-D* (2016) Kin2, the budding yeast ortholog of animal MARK/PAR-1 kinases, localizes to the sites of polarized growth and may regulate septin organization and the cell wall. PLoS ONE 11(4): e0153992. 4. Wu H, Guo J, Zhou Y-T, Gao X-D* (2015) The anillin-related region of Bud4 is the major functional determinant for Bud4’s function in septin organization during bud growth and axial bud-site selection in budding yeast. Eukaryot. Cell 14(3): 241-251. 5. He F, Nie W-C, Tong Z, Yuan S-M, Gong T, Liao Y, Bi E, Gao X-D* (2015) The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast. PLoS ONE 10(4): e0123326. 6. Li Y-Q, Li M, Zhao X-F, Gao X-D* (2014) A role for the Rap GTPase YlRsr1 in cellular morphogenesis and the involvement of YlRsr1 and the Ras GTPase YlRas2 in bud-site selection in the dimorphic yeast Yarrowia lipolytica. Eukaryot. Cell 13(5): 580-590. 7. Li M, Li Y-Q, Zhao X-F, Gao X-D* (2014) Roles of the three Ras proteins in the regulation of dimorphic transition in the yeast Yarrowia lipolytica. FEMS Yeast Res. 14(3): 451-463. 8. Gong T, Liao Y, He F, Yang Y, Yang D-D, Chen X-D, Gao X-D* (2013) Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: Requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2. Eukaryot. Cell 12(2): 368-377. 9. Liao Y, He F, Gong T, Bi E, Gao X-D* (2013) Msb1 interacts with Cdc42, Boi1, and Boi2 and may coordinate Cdc42 and Rho1 functions during early stage of bud development in budding yeast. PLoS One 8:e66321. 10. Zhao XF, Li M, Li YQ, Chen XD, Gao X-D* (2013) The TEA/ATTS transcription factor YlTec1p represses the yeast-to-hypha transition in the dimorphic yeast Yarrowia lipolytica. FEMS Yeast Res. 13:50-61. 11. Tang Y, Gao X-D, Wang Y, Yuan BF, Feng YQ (2012) Widespread existence of cytosine methylation in yeast DNA measured by gas chromatography/mass spectrometry. Anal. Chem. 84:7249-55. 12. Guo J, Gong T, Gao X-D* (2011) Identification of an amphipathic helix important for the formation of ectopic septin spirals and axial budding in yeast axial landmark protein Bud3p. PLoS One 6:e16744. 13. Tong Z, Gao X-D, Howell AS, Bose I, Lew DJ, Bi E (2007) Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. J. Cell Biol. 179:1375-1384. 14. Gao X-D, Sperber LM, Kane SA, Tong Z, Tong AHY, Boone C, Bi E (2007) Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Mol. Biol. Cell 18:2542-2560. 15. Tcheperegine SE, Gao X-D, Bi E (2005) Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components. Mol. Cell. Biol. 25:8567-8580. 16. Gao X-D, Caviston JP, Tcheperegine SE, Bi E (2004) Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth. Mol. Biol. Cell 15:3977-3985. 17. Grimme SJ, Gao X-D, Martin PS, Tu K, Tcheperegine SE, Corrado K, Farewell AE, Orlean P, Bi E (2004) Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Mol. Biol. Cell 15:2758-2770. 18. Gao X-D, Albert S, Tcheperegine SE, Burd CG, Gallwitz D, Bi E (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J. Cell Biol. 162:635-646.