周荣家 - 武汉大学 - 生命科学学院

个人简介

主要教育及工作经历 1978-82和86年四川农业大学取得学士和硕士学位 1989-92华西医科大学取得博士学位 1992-94武汉大学生物（遗传）学博士后 1994.9-12美国加州大学旧金山分校（UCSF）访问学习 1996.6-8 澳大利亚Latrobe 大学访问学习 1996.10-97.5 美国Louisiana州立大学访问学习 1998.11-99.11 法国人类遗传学研究所（CNRS）访问学习 2002.12-03.3 法国巴斯德研究所（Pasteur）访问学习 2006.5. 香港大学客座教授

研究领域

类和小鼠等脊椎动物的发育从受精卵开始，经历早期胚胎发育与分化，器官形成与胎儿生长，直至完整生命体出生。我们主要探索脊椎动物胚胎发育与分化过程中所涉及的众多基因的时空表达与调控。通过进化时空和多个模式物种的比较研究，以及功能基因组、转录组、蛋白质组、转基因动物、基因敲除及生物信息技术等多种现代生命科学手段，研究基因-发育-进化等生命本质, 尤其关注胚胎发生、细胞分化、干细胞命运、生殖与发育等生命活动及其分子演化和分子病理机制。

近期论文

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1. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H., Zhou R., RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934. 2. Song Y., Shang D., Cheng H., Zhou R., The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714. 3. Zhao X, Luo M, Li Z, Zhong P, Cheng Y, Lai F, Wang X, Min J, Bai M, Yang Y, Cheng H, Zhou R., Chromosome-scale assembly of the Monopterus genome. Gigascience. 2018;7(5):1-9. 4. Liu J., Shang D., Xiao Y., Zhong P., Cheng H., Zhou R., Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013. 5. Luo M, Zhao X, Song Y, Cheng H, Zhou R., Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983. 6. Xiao Y, Gao M, Gao L, Zhao Y, Hong Q, Li Z, Yao J, Cheng H, Zhou R., Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82. 7. Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H., Zhou R., MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098. 8. Fu X., Cheng Y., Yuan J., Huang C., Cheng H., Zhou R., Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158. 9. Chen K., Huang C., Yuan J., Cheng H., Zhou R., Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014,31(8):2194-211. 10. Zuo Z, Peng D, Yin X, Zhou X, Cheng H, Zhou R., Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013,30(9):2087-98. 11. Hou Y, Yuan J, Zhou X, Fu X, Cheng H, Zhou R., DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012;8(5):e1002716. 12. Zhou F, Zhao W, Zuo Z, Sheng Y, Zhou X, Hou Y, Cheng H, Zhou R., Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40. 13. Zhou X, Zuo Z, Zhou F, Zhao W, Sakaguchi Y, Suzuki T, Suzuki T, Cheng H, Zhou R., Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85. 14. Ying M, Chen B, Tiana Y, Hou Y, Li Q, Shang X, Sun J, Cheng H., Zhou R., Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813. 15. Huang X, Guo Y, Shui Y, Gao S, Yu H,, Cheng H., Zhou R., Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024. 16. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R., Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393. 17. Zhou R., N. Bonneaud, C-X Yuan, P. de Barbara, B Boizet, S Tibor, G Scherer, RG Roeder, F Poulat, P Berta, SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res. 2002, 30(14): 3245-52.