吴英亮 - 武汉大学 - 生命科学学院

个人简介

学习简历： 1999.9-2002.7 武汉大学化学系博士研究生 1996.9-1999.7 南昌大学化学系硕士研究生 1992.9-1996.7 南昌大学化学系本科工作简历： 2009.11-至今武汉大学生命科学学院，教授、博士生导师 2008.9-2009.10 武汉大学生命科学学院，副教授、博士生导师 2007.10-2008.9 加拿大Ambrilia生物制药公司，多肽药物设计咨询专家 2004.11-2008.8 武汉大学生命科学学院副教授、硕士生导师 2002.9-2004.10 武汉大学生命科学学院博士后

研究领域

1. 动物资源的保护与利用 2. 蝎生物学　　综合运用不同学科（如生态学、化学、生物学、药学）基础知识，在系统水平上认识蝎及其它动物的生物学特征及分子基础、挖掘药用前景多肽分子、开展药用多肽的结构功能关系及与受体作用机制，致力于动物资源的保护与持续利用。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Fan Yang, Shuang Liu, Yaoyun Zhang, Chenhu Qin, Lingna Xu, Wenhua Li, Zhijian Cao, Wenxin Li*, Yingliang Wu*. Expression of recombinant α-toxin BmKM9 from scorpion Buthus martensii Karsch and its functional characterization on sodium channels. Peptides, 2017.10, published online 2. 毛歆，刘辉，李文鑫，吴英亮*。马氏正钳蝎的形态和结构特征。动物学杂志，2017，52(3): 468-477 3. Shen B, Cao Z, Li W, Sabatier JM*, Wu Y*. Treating autoimmune disorders with venom-derived peptides. Expert Opin Biol Ther. 2017, 17(9): 1065-1075 4. Zhang C,Xie Z,Li X,Chen J,Feng J,Lang Y,Yang W,Li W,Chen Z,Yao J,Cao Z*,Wu Y*. Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem J, 2016, 473(9): 1257-66 5. Jing Feng,Zili Xie,Weishan Yang,Yonghui Zhao,Fang Xiang,Zhijian Cao,Wenxin Li, Zongyun Chen*,Yingliang Wu*. Human beta-defensin 1, a new animal toxin-like blocker of potassium channel. Toxicon, 2016, 113: 1-6 6. Lanxia Meng, Zili Xie, Qian Zhang, Yang Li, Fan Yang, Zongyun Chen, Wenxin Li, Zhijian Cao*, Yingliang Wu*. Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin. J Biol Chem, 2016, 291: 7097-7106 7. Xie Z, Feng J, Yang W, Xiang F, Yang F, Zhao Y, Cao Z, Li W, Chen Z*, Wu Y*. Human α-defensins are immune-related Kv1.3 channel inhibitors: new support for their roles in adaptive immunity. FASEB J, 2015, 29(10): 4324-4333 8. Zongyun Chen, Youtian Hu, Jing Hong, Jun Hu, Weishan Yang, Fang Xiang, Fan Yang, Zili Xie, Zhijian Cao, Wenxin Li, Donghai Lin*, Yingliang Wu*. Toxin acidic residue evolution function-guided design of de novo peptide drugs for immunotherapeutic target Kv1.3 channel. Scientific Reports, 2015, 5: 9881 9. Jing Feng, Weishan Yang, Zili Xie, Fang Xiang, Zhijian Cao, Wenxin Li Hongzhen Hu, Zongyun Chen*, Yingliang Wu*. Kv channel S1-S2 linker working as a binding site of human β-defensin 2 for channel activation modulation. J Biol Chem, 2015, 290(25): 15487-95 10. Weishan Yang, Jing Feng, Fang Xiang, Zili Xie, Guoyi Zhang, Jean-Marc Sabatier, Zhijian Cao, Wenxin Li, Zongyun Chen*, Yingliang Wu*. Endogenous animal toxin-like human β-defensin 2 inhibits own K+ channels through interaction with channel extracellular pore region. Cellular and Molecular Life Science, 2015, 72: 845-853 11. Fang Xiang, Zili Xie, Weishan Yang, Jing Feng, Zhijian Cao, Wenxin Li, Zongyun Chen*, Yingliang Wu*. Plectasin, first animal toxin-like fungal defensing blocking potassium channels through recognizing channel pore region. Toxins, 2015, 7: 34-42 12. Lingna Xu, Tian Li, Honglian Liu, Fan Yang, Songping Liang, Zhijian Cao, Wenxin Li, Yingliang Wu*. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus. Toxicon, 2014, 90: 318-325 13. Zongyun Chen, Youtian Hu, Jun Hu, Weishan Yang, Jean-Marc Sabatier, Michel De Waard, Zhijian Cao, Wenxin Li, Song Han*, Yingliang Wu*. Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochem Biophys Res Commun, 2014, 447(1): 70-76 14. You-Tian Hu, Jun Hu, Tian Li, Jingjing Wei, Jing Feng, Yimei Du, Zhijian Cao, Wenxin Li*, Yingliang Wu*. Open Conformation of hERG Channel Turrets Revealed by a Specific Scorpion Toxin BmKKx2. Cell & Bioscience, 2014, 4: 18 15. Panpan Hou, Rong Zhang, Yongfeng Liu, Jing Feng, Wei Wang, Yingliang Wu and Jiuping Ding*. Physiological Role of Kv1.3 Channel in T Lymphocyte Cell Investigated Quantitatively by Kinetic Modeling. PLoS ONE, 2014, 9(3): e89975 16. Tian Li, Lingna Xu, Honglian Liu, Yawen He, Wenxin Li*, Yingliang Wu*. Characterization of a novel Bm TX47 toxin modulating sodium channels: crucial role of expression vectors in toxin pharmacological activity. Toxins, 2014, 6: 816-829 17. Cao ZJ, Di ZY, Wu YL*, Li WX*. Overview of scorpion species and their toxins from China. Toxins, 2014, 6: 796?-815 18. Chang Xie, Tian Li,Lingna Xu,Congya Yu,Zhijian Cao,Wenxin Li*, Yingliang Wu*. Kv1.3 potassium channel-blocking toxin Ctri9577, novel gating modifier of Kv4.3 potassium channel from the scorpion toxin family. Biochem Biophys Res Commun, 2014, 444(3): 406-410 19. Jian Ma, Youtian Hu, Mingxiong Guo, Zan Huang, Wenxin Li*, Yingliang Wu*. hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562. PLoS ONE, 2013, 8(12): e84903