姚镜 - 武汉大学 - 生命科学学院

个人简介

学习经历： 2006/09－2009/07，美国纽约州立布法罗大学生理与生物物理系，联合培养博士生 2006/09－2009/07，华中科技大学生命科学与技术学院生物物理专业，博士 2002/09－2005/07，华中科技大学生命科学与技术学院生物物理专业，硕士 1996/09－2000/07，华中科技大学生命科学与技术学院生物技术专业，本科主要工作经历与任职情况： 2012/12-至今，武汉大学，生命科学学院，细胞与发育生物学系，教授 2011/10，受聘为湖北省楚天学者特聘教授 2011/02-2012/12，华中科技大学，生命科学与技术学院，分子生物物理教育部重点实验室，教授 2005/10-2011/01，美国纽约州立布法罗大学，生理与生物物理系，先后担任研究助理与博士后

研究领域

离子通道的结构和功能正常是维持生命过程的基础，其结构或功能的异常会导致许多先天性或后天获得性疾病，称为离子通道病。离子通道功能的减弱或增强均会导致机体生理功能的紊乱，主要累及神经、肌肉、心脏、肾脏等系统或器官。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(1) Yao Xiao, Maomao Gao, Luna Gao, Yu Zhao, Qiang Hong, Zhigang Li, Jing Yao, Hanhua Cheng#, and Rongjia Zhou#. Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016 Aug 23. pii: S2213-6711(16)30144-8. doi: 10.1016/j.stemcr.2016.07.020. (2) Yujie Ren, Yin Zhao, Dandan Lin, Ximing Xu, Qiyun Zhu, Jing Yao, Hong-Bing Shu and Bo Zhong#. The type I interferon-IRF7 axis mediates transcriptional expression of Usp25. J. Biol. Chem. 2016 Jun 17;291(25):13206-15. doi: 10.1074/jbc.M116.718080. (3) Chuangeng Zhang*, Zili Xie*, Xinxin Li, Jing Chen, Jing Feng, Yange Lang, Weishan Yang, Wenxin Li, Zongyun Chen, Jing Yao, Zhijian Cao#and Yingliang Wu#. Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem. J., 2016 May 1;473(9):1257-66. doi: 10.1042/BCJ20160178. Epub 2016 Mar 7. (4) Luna Gao, Pu Yang, Peizhong Qin, Yungang Lu, Xinxin Li, Quan Tian, Yang Li, Chang Xie, Jin-Bin Tian, Chengwei Zhang, Changlin Tian, Michael X. Zhu#, Jing Yao#. Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. Sci. Rep. 2016 Feb; 6, 20791; doi: 10.1038/srep20791. (#corresponding author) (5) Chang Xie, Haowen Liu, Na Pan, Jiuping Ding and Jing Yao#. The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols. Acta Pharmacol. Sin. 2016 Jan; 37(1):124-33. (#corresponding author) (6) Xiang Yang Zhang*, Jingmin Wen*, Wei Yang*, Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou, Jing Yao#, Xue Zhang, Jing Yu Liu#. Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain. Am. J. Hum. Genet., 2013 Nov. 7; 93(5):957-66. Doi: 10.1016/j.ajhg.2013.09.016 (#corresponding author) (7) Lu Zeng, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao, Jing Yao and Xianqin Zhang#. A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family. Mol Vis. 2013 Nov 14;19:2244-9. (8) Ying Wu*, Yongfeng Liu*, Panpan Hou*, Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li, Jing Yao, Yuexuan Zhang, Feng Qin#, Jiuping Ding#. TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons. PLoS One. 2013 Oct 16; 8(10):e78203. doi: 10.1371/journal.pone.0078203. (9) Panpan Hou*, Wenping Zeng*, Geliang Gan*, Caixia Lv*, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D., Wei, Sheng Wang and Jiuping Ding. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2). Sci Rep. 2013 Apr 16; 3:1666. P1-8. doi: 10.1038/srep01666. (10) Lisi Wei*, Su Chen*, Xianju Huang, Jing Yao and Xiangming Liu. Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons. Eur J Pharmacol. 2013 Feb 28; 702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052. Epub 2013 Feb 8. (11) Wei Wang*, Feng Xiao*, Xuhui Zeng, Jing Yao, Ming Yuchi and Jiuping Ding. Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents. Plos One. 2012 Mar; 7(4):e35208. Epub 2012 Apr 20. (12) Cheng Wang*, Yulei Li*, Lei Shi*, Jie Ren, Monica Patti, Tao Wang, João R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang, Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang & Jing-Yu Liu. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet. 2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077. (13) Beiying Liu*, Jing Yao* and Feng Qin. Hysteresis of Gating Underlines Sensitization of TRPV3 Channels. J Gen Physiol. 2011 Nov; 138(5):509-20. (*Co-first author, Recommended by Faculty of 1000) (14) Jing Yao*, Beiying Liu* and Feng Qin. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl. Aca. Sci. USA. 2011 Jul 5; 108(27):11109-14. (15) Jing Yao*, Beiying Liu* and Feng Qin. Pore turret of thermal TRP channels is not essential for temperature sensing. Proc. Natl. Aca. Sci. USA. 2010, Aug 10; 107(32):E125. (16) Jing Yao*, Beiying Liu* and Feng Qin. Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels. Biophys. J. 2010 Sep 22; 99(6):1743-53. (17) Beiying Liu*, Jing Yao* Yingwei Wang*, Hui Li and Feng Qin. Proton inhibition of Unitary Currents of Vanilloid Receptors. J Gen Physiol.2009 Aug 31; 134(3):243-58. (*Co-first author) (18) Jing Yao*, Beiying Liu* and Feng Qin. Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies. Biophys. J. 2009 May 6; 96(9): 3611-9. (19) Jing Yao and Feng Qin. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1. PLos. Biol. 2009 Feb.24, 7 (2): e46.