李友军 - 武汉大学 - 生命科学学院

个人简介

学习经历 2002-2004 匹兹堡大学医学院儿童医院血液与肿瘤学系　博士后 1996-2001 中南大学湘雅医学院肿瘤研究所硕-博士 1992-1996 湖南师范大学生物系　　学士主要工作经历与任职情况： 2011—至今　湖北省楚天学者计划特聘教授 2010—至今　武汉大学生命科学学院　教授,博士生导师 2007-2010　匹兹堡大学医学院儿童医院血液与肿瘤学系　研究助理教授 2004-2007　匹兹堡大学儿童医院血液与肿瘤学系　高级研究助理 2001-2002　中南大学湘雅医学院肿瘤研究所讲师

研究领域

应用现代分子和细胞生物学技术，结合肿瘤组织和动物模型研究肿瘤代谢重编程的分子基础，为肿瘤的防治提供理论依据和应用基础。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Gu L, Zhu Y, Lin X, Li Y, Cui K, Prochownik EV, Li Y* (2018). Amplification of glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1 to promote hepatocarcinogenesis. Cancer Research, 78:5808-5819. 2. Li W, Cui K, Prochownik EV, Li Y* (2018). The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth. Cell Death & Disease 9: 482. doi: 10.1038/s41419-018-0523. 3. Zhu Y, Gu L, Li Y, Lin X, Shen H, Cui K, Chen L, Zhou F, Zhao Q, Zhang J, Zhong B, Prochownik E, Li Y*(2017). MiR-148a inhibits colitis and colitis-associated tumorigenesis in mice. Cell Death & Differentation doi:10.1038/cdd.2017.151. 4. Shen H, Xing C, Cui K, Li Y, Zhang J, Du R, Zhang X, Li Y*(2017). MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1. Cell Death & Differentation 24:1253-1262. 5. Cheng L, Zhu Y, Han H, Zhang Q, Cui K, Shen H, Zhang J, Yan J, Prochownik E, Li Y*(2017). MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice. Cell Death & Disease 8:e2916. 6. Kulkarni S, Dolezal JM, Wang H, Jackson L, Lu J, Frodey BP, Dosunmu-Ogunbi A, Li Y, Fromherz M, Kang A, Santana-Santos L, Benos PV, Prochownik EV*(2017). Ribosomopathy-like properties of murine and human cancers. PLoS One 12:e0182705. 7. Han H, Chen Y, Cheng L, Prochownik EV, Li Y*(2016). microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13. Oncotarget 7:16409-16419. 8. Han H, Li W, Shen H, Zhang J, Zhu Y, Li Y*(2016). microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect. J Mol Cell Biol. 8:400-410. 9. Li Y*, Zhu Y, Prochownik EV. (2016) MicroRNA-based screens for synthetic lethal interactions with c-Myc. RNA Disease 3. pii: e1330. 10. Shen H, Li W, Tian Y, Xu P, Wang H, Zhang J, Li Y*(2015).Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob 2 in Hepatocellular Carcinoma. Journal of Cellular Biochemistry 8:1563–1573. 11. Lu L, Han H, Tian Y, Li W, Zhang J, Feng M, Li Y*(2015). Aurora kinase A mediates c-Myc's oncogenic effects in hepatocellular carcinoma. Molecular Carcinogenesis 11:1467–1479. 12. Han H, Sun D, Li W, Shen H, Zhu Y, Li C, Chen Y, Lu L, Li W, Zhang J, Tian Y and Li Y*(2013). A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis. Hepatology 6:2378–2389. 13. Wu Q, Xu FL, Li Y, Prochownik EV, Saunders WS*(2010). The c-Myc target Glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells. PLoS One 5:10819-10825. 14. Li Y, Xu FL, Lu J, Saunders WS, Prochownik EV*(2010). Widespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase. J Biol Chem 17: 13183-13192. 15. Li Y, Lu J, Prochownik EV*(2009). Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha. J Biol Chem 3: 1410-1418. 16. Li Y, Lu J, Cohen D, Prochownik EV*(2008). Transformation, genomic instability and senescence mediated by platelet/megakaryocyte glycoprotein Ibalpha. Oncogene 11:1599–1609. 17. Prochownik EV, Li Y (2007). The ever expanding role for c-Myc in promoting genomic instability. Cell Cycle 9:1024-1033. 18. Li Y, Lu J, Prochownik EV*(2007). c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha. Proc Natl Acad Sci USA 9:3490-3495. 19. Li Y, Lu J, Prochownik EV*(2007). Dual role for SUMO E2 conjugase Ubc 9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor. J Biol Chem 18:13363-13434. 20. Li Y, Rogulski K, Zhou Q, Sims PJ, Prochownik EV*(2006). The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1. Mol Cell Biol 9:3401-3444.