李文化 - 武汉大学 - 生命科学学院

个人简介

学习经历 1992－1996 中南民族大学，学士 1999－2004 武汉大学生命科学学院，博士 2004－2008 哈佛大学医学院，博士后主要工作经历及任职情况 1996－1999 湖北省农业科学院，实习研究员 2008－2012 武汉大学生命科学学院，副教授 2012－至今武汉大学生命科学学院，教授

研究领域

1.原癌基因和抑癌基因在肿瘤发生发展中的信号转导及调控关系； 2.针对特定靶位点的抗癌药物分子机理研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li*. Combination Therapy with Protein Kinase Inhibitor H89 and Tetrandrine Elicits Enhanced Synergistic Antitumor Efficacy. Journal of Experimental & Clinical Cancer Research. 2018, 37:114 2.Guixian Wu, Ting Liu, Han Li, Yafang Li, Dengju Li, Wenhua Li*. c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation. Cell Death Disease. 2018, 9:473 3.Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li*. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. Journal of Experimental & Clinical Cancer Research. 2018, 37(1):7 4.Ting Liu, Zhenxing Zhang, Chunjie Yu, Chang Zeng, Xiaoqing Xu, Guixian Wu, Zan Huang, Wenhua Li*. Tetrandrine antagonizes acute megakaryoblastic leukemia growth by forcing autophagy-mediated differentiation. British Journal of Pharmacology. 2017, 174:4308-4328. 5.Yicheng Chen, Chang Zeng, Yao Zhan, Haiqing Wang, Xinnong Jiang, Wenhua Li*. P85α aberrantly low expression in stromal fibroblasts promotes breast cancer cell metastasis through exosomes mediated paracrine Wnt10b.Oncogene. 2017, 36:4692-4705. 6.Zhaohua Ping, Hui Xu, Ting Liu, Junchao Huang, Yan Meng, Xiaojuan Xu*, Wenhua Li* and Lina Zhang*. Anti-hepatoma activity of the stiff branched -D-glucan and effects of molecular weight. Journal of materials Chemistry B. 2016, 4:4565-4573 7.Jiali Wan, Jia-Hong Wang, Ting Liu, Zhixiong Xie, Xue-Feng Yu, Wenhua Li*. Surface chemistry but not aspect ratio mediates the biological toxicity of gold nanorods in vitro and in vivo. Scientific Reports. 2015, 5:11398; doi: 10.1038/srep11398. 8.Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu*, Wenhua Li*. Tetrandrine inhibits proliferation and induces autophagy mediate differentiation by activating ROS and Notch1 signaling in NB4 leukemia cells. Oncotarget. 2015, 6:7992-8006. 9.Haiqing Wang, Ting Liu, Lu Li, Qin Wang, Chunrong Yu, Xin Liu*, Wenhua Li*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell & Bioscience. 2015 5:4. 10.Liufeng Mei, Yicheng Chen, Zhimeng Wang, Jian Wang, Jiali Wan, Chunrong Yu, Xin Liu, Wenhua Li*. Synergistic antitumor effects of tetrandrine and chloroquine combination therapy in human cancer. British Journal of Pharmacology. 2015, 172:2232–45. 11.Ke Gong, Zhenxing Zhang, Yicheng Chen,Hong-Bing Shu, Wenhua Li*. Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma. European Journal of Pharmacology. 2014, 738:142-52. 12.Yu Song, Ke Gong, Hong Yan, Wei Hong, Le Wang, Yingliang Wu, Wenhua Li*, Wenxin Li*, Zhijian Cao*. Sj7170, a serine protease peptide inhibitor from the venom of the scorpion Scorpiops jendeki, promotes tumorigenesis and metastasis of human glioblastoma cells in vitro and in vivo. Journal of Biological Chemistry. 2014, 289:11667-80. 13.Jingru Li, Yicheng Chen, Jiali Wan, Xin Liu, Chunrong Yu, Wenhua Li*. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells. British Journal of Pharmacology. 2014, 171:3182-95. 14.Jiali Wan, Ting Liu, Liufeng Mei, Jingru Li, Ke Gong, Chunrong Yu, Wenhua Li*. Synergistic antitumor activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling. British Journal of Cancer. 2013,109:342-50. 15.Yan Zhang, Wenhua Li*, Liming Wang, Ping Shen, Zhixiong Xie. Adenosine monophosphate affects competence development and plasmid DNA transformation in Escherichia coli. Current Microbiology. 2013,67:550-6. 16.Hai-Ming Hu, Yicheng Chen, Lu Liu, Chuan-Geng Zhang, Wei Wang, Ke Gong, Zan Huang, Ming-Xiong Guo, Wen-Xin Li* and Wenhua Li*. C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis. FASEB Journal. 2013, 27:163-73. 17.Ke Gong, Chao Chen, Yao Zhan, Yan Chen, Zebo Huang, Wenhua Li*. Autophagy-related gene 7 (Atg7) and reactive oxygen species (ROS)/ extracellular-signal-regulated kinase (ERK) regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. Journal of Biological Chemistry. 2012, 287:35576-88. 18.Yao Zhan, Ke Gong, Chao Chen, Haiqing Wang, Wenhua Li*. p38 MAP kinase functions as a switch in MS-275 induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells. Free Radical Biology and Medicine. 2012, 53:532-43.