程汉华 - 武汉大学 - 生命科学学院

个人简介

教育经历： 1979-1983　华中农业大学，学士学位 1983-1986　四川农业大学，硕士学位 1990-1993　华西医科大学，博士学位工作经历： 1986－1990　华中农业大学，助教 1993－至今　武汉大学，讲师、副教授、教授、博士生导师

研究领域

我们的研究领域是动物及人类分子细胞生物学。通过人类及多模式物种（主要是小鼠，斑马鱼和黄鳝）研究早期胚胎发育、分化和器官形成过程中所涉及的众多基因的时空表达与调控；研究基因-发育-进化等生命本质, 尤其关注生殖与发育、细胞分化、干细胞命运及小RNA等生命活动及其分子病理机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H., Zhou R., RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934. 2. Song Y., Shang D., Cheng H., Zhou R., The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714. 3. Zhao X, Luo M, Li Z, Zhong P, Cheng Y, Lai F, Wang X, Min J, Bai M, Yang Y, Cheng H, Zhou R., Chromosome-scale assembly of the Monopterus genome. Gigascience. 2018;7(5):1-9. 4. Liu J., Shang D., Xiao Y., Zhong P., Cheng H., Zhou R., Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013. 5. Luo M, Zhao X, Song Y, Cheng H, Zhou R., Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983. 6. Xiao Y, Gao M, Gao L, Zhao Y, Hong Q, Li Z, Yao J, Cheng H, Zhou R., Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82. 7. Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H., Zhou R., MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098. 8. Fu X., Cheng Y., Yuan J., Huang C., Cheng H., Zhou R., Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158. 9. Chen K., Huang C., Yuan J., Cheng H., Zhou R., Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014,31(8):2194-211. 10. Zuo Z, Peng D, Yin X, Zhou X, Cheng H, Zhou R., Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013,30(9):2087-98. 11. Hou Y, Yuan J, Zhou X, Fu X, Cheng H, Zhou R., DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012;8(5):e1002716. 12. Zhou F, Zhao W, Zuo Z, Sheng Y, Zhou X, Hou Y, Cheng H, Zhou R., Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40. 13. Zhou X, Zuo Z, Zhou F, Zhao W, Sakaguchi Y, Suzuki T, Suzuki T, Cheng H, Zhou R., Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85. 14. Ying M, Chen B, Tiana Y, Hou Y, Li Q, Shang X, Sun J, Cheng H., Zhou R., Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813. 15. Huang X, Guo Y, Shui Y, Gao S, Yu H,, Cheng H., Zhou R., Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024. 16. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R., Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393.