王琰 - 武汉大学 - 生命科学学院

个人简介

学习经历： 2003.9- 2008.7: 博士中国科学院生物物理研究所。(导师：徐涛) 1999.9- 2003.7: 学士南开大学生物物理系。主要工作经历与任职情况： 2015-至今: 研究员。武汉大学生命科学学院 2016　受聘珞珈特聘教授 2008-2015: 博士后。霍华德休斯医学院（HHMI）& 德克萨斯大学西南医学中心 (导师: Helen Hobbs。美国科学院、医学院、艺术与科学学院院士) 。 2007.11-2008.1: 访问学者。加拿大多伦多大学。

研究领域

高血脂、高血压以及胰岛素抵抗等代谢性疾病呈现越来越广泛的流行趋势。营养过剩及不良生活习惯被认为是导致这些疾病发生的重要因素。

近期论文

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1) Fu T, Guan YY, Xu JJ, Wang Y#. APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo. Biochim Biophys Acta. 2017 May 8. pii: S1388-1981(17)30076-8 2) Xie C, Zhang YP, Song L, Luo J, Qi W, Hu J, Lu D, Yang Z, Zhang J, Xiao J, Zhou B, Du JL, Jing N, Liu Y, Wang Y, Li B, Song BL, Yan Y. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Res. 2016 Oct;26(10):1099-1111. 3) Wang Y, McNutt M, Banfi S, Levin M, Holland W, Gusarova V, Gromada J, Cohen JC, Hobbs HH. Hepatic ANGPTL3 Regulates Adipose Tissue Energy Homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5. 4) Wang Y, Gusarova V, Banfi S, Gromada J, Valenzuela D, Cohen JC, Hobbs HH. Inactivation of ANGPTL3 Reduces Hepatic VLDL-triglyceride Secretion. J Lipid Res. 2015 Jul;56(7):1308-17. 5) Gusarova V, Alexa CA, Wang Y, Rafique A, Kim JH, Buckler D, Mintah IJ, Shihanian LM, Cohen JC, Hobbs HH, Xin Y, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. J Lipid Res. 2015 Jul;56(7):1308-17 6) Wang Y*, Quagliarini F*, Gusarova V, Gromada J, Valenzuela D, Cohen JC, Hobbs HH. Mice Lacking ANGPTL8 (Betatrophin) Manifest Disrupted Triglyceride Metabolism Without Impaired Glucose Homeostasis. Proc Natl Acad Sci U S A. 2013 Oct 1. 110(40):16109-14 7) Quagliarini F*, Wang Y*, Kozlitina J, Grishin N, Hyde R, Boerwinkle E, Cohen JC, Hobbs HH . Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A. 2012 Nov 27. 109(48):19751-6 8) Wang Y, Huang Y, Hobbs HH, Cohen JC. Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. J Lipid Res. 2012 Sep;53(9):1932-43. 9) Bai L*, Wang Y*, Fan J*, Chen Y, Ji W, Qu A, Xu P, James DE & Xu T Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab. 2007 Jan;5(1):47-57 10) Chen Y*, Wang Y*, Zhang J*, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60 11) Wang Y*, Zhang J*, Chen Y*, Jiang L, Ji W, Xu T. Characterization of GLUT4-containing vesicles in 3T3-L1 adipocytes by total internal reflection fluorescence microscopy. Sci China C Life Sci. 2009 Jul; 52(7):665-71 12) Chen Y*, Wang Y*, Ji W*, Xu P, Xu T. A pre-docking role for microtubules in insulin-stimulated glucose transporter 4 translocation. FEBS J. 2008 Feb;275(4):705-12 13) Jiang L, Fan J, Bai L, Wang Y, Chen T, Yang L, Chen L, Xu T. Direct quantification of fusion rate reveals a distal role for AS160 in insulin stimulated fusion of GLUT4 storage vesicles. J Biol Chem. 2008 Mar 28; 283(13):8508-16 14) Bai L, Zhu D, Zhou K, Zhou W, Li D, Wang Y, Zhang R, Xu T (2006) Differential Properties of GTP- and Ca2+-Stimulated Exocytosis from Large Dense Core Vesicles. Traffic, 2006 Apr;7(4):416-28.