殷雷 - 武汉大学 - 生命科学学院

个人简介

学习经历 2002 - 2007博士中国科学院生物物理研究所生物大分子国家重点实验室导师：王大成院士 1998 - 2002学士武汉大学生命科学学院基地班专业主要工作经历与任职情况： 2013 - 至今　教授武汉大学生命科学学院病毒学国家重点实验室 2008 - 2013　研究助理美国霍华德休斯医学研究所（HHMI）导师：John Kappler 院士 Philippa Marrack 院士英国皇家学会会员

研究领域

病原识别是免疫应答中的极其重要的事件，若有效识别外源病菌或肿瘤抗原则能产生免疫保护作用，若异常识别自身抗原则又可造成机体组织的免疫损害，直接影响感染性疾病的免疫防治、肿瘤免疫防治、过敏与自身免疫性疾病治疗。此病原识别环节的科学重要性和医药靶标优异性已在CAR-T(通过嵌合抗原受体精准识别病原分子)和TCR-T（通过高亲和T细胞受体特异性识别病原分子）等革命性肿瘤免疫疗法研究上不断凸显。

近期论文

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1.Wei P, Yang Y, Liu Z, Luo Z, Tu W, Han J, Deng Y, Yin L*. Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis. J Invest Dermatol. 2017 Oct; 137(10):2238-2241 (Highlighted by Commentary in J Invest Dermatol. 2017 Oct; 137:2042-2045) （一区） 2.Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P, Yin L*. Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance. FASEB J. 2017 Oct (cover story) （二区） 3.Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL,Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW*, Song BL*. Cholesterol　modification of Smoothened is required for hedgehog signaling. Molecular Cell. 2017; 66:1-9 （一区） 4.Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB*. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity. 2016 Sep 20; 45(3):555-69. （一区） 5.Xia H, Wang P, Wang GC, Yang J, Sun X, Wu W, Qiu Y, Shu T, Zhao X, Yin L, Qin CF, Hu Y, Zhou X*. Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-independent RNA Chaperone. PLOS Pathogens. 2015; 11(7): e1005067. doi: 10.1371/journal.ppat.1005067 （一区） 6.Yang J, Cheng Z, Zhang S, Xiong W, Xia H, Qiu Y, Wang Z, Wu F, Qin CF, Yin L, Hu Y and Zhou X*. A Cypovirus VP5 Displays the RNA Chaperone-like Activity that Destabilizes RNA Helices and Accelerates Stranding Annealing. Nucleic Acids Research. 2014; 42(4): 2538-2554. （一区） 7.Yin L*, Dai S, Clayton G, Gao W, Wang Y, Kappler J, Marrack P*. Recognition of self and altered self by T cells in autoimmunity and allergy. Protein & cell 2013 Jan; 4(1):8-16 (* Corresponding) （二区） 8.Yin L, Crawford F, Marrack P, Kappler J*, Dai S*. T-cell receptor(TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. PNAS（Proceedings of the National Academy of Sciences）2012 Nov 6; 109(45):18517-22 (Recommended by Faculty of 1000) （一区） 9.Yin L, Scott-Browne J, Kappler J, Gapin L, Marrack P*. T cells and their eons-old obsession with MHC. Immunological Reviews. 2012 Nov; 250(1):49-60. （一区） 10.Yin L#, Huseby E#, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler J*. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity. 2011 Jul 22; 35(1):23-33(# Contributed equally) (Highlighted by Commentary in Immunity 2011 Jul 22; 35:1-3, Recommended by Faculty of 1000) （一区） 11.Hu Y#, Gai Y#, Yin L#, Wang X, Feng C, Feng L, Li D, Jiang XN, Wang DC*. Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms. Plant Cell. 2010 Sep; 22(9):3093-104.(# Contributed equally) （一区）