孙慧 - 武汉大学 - 生命科学学院

个人简介

学习经历： 1990-1994，华中农业大学，学士 1994-1997，南京农业大学，硕士 1997-2000，福建农业大学，博士，导师：谢联辉院士工作经历： 1）2000-2002，　武汉大学病毒系，博士后 2）2002-2011，　武汉大学生物化学系，副教授 3）2011-，武汉大学生物化学系，教授 4）2012-2013，　美国霍普金斯大学生物化学系，访问学者

研究领域

1）糖的研究工具（凝集素和抗体）的制备和改造。 2）凝集素激活免疫细胞，作为抗肿瘤药物研究。 3）蛋白质糖基化修饰及功能研究。 4）糖修饰的改变与肿瘤发生的关系：肿瘤早期标志物的鉴定及机理研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu W, Han G, Yin Y, Jiang S, Yu G, Yang Q, Yu W, Ye X, Su Y, Yang Y, Hart GW*, Sun H*. AANL (Agrocybe aegerita lectin 2) is a new facile tool to probe for O-GlcNAcylation. Glycobiology. 2018 Jun 1;28(6):363-373. 2. Liu W, Yu G, Yu W, Ye X, Jin Y, Shrestha A, Yang Q, Sun H*. Autophagy Inhibits Apoptosis Induced by agrocybe aegerita Lectin in Hepatocellular Carcinoma. Anticancer Agents Med Chem. 2017;17(2):221-229. 3. Jin Y, Wang J, Ye X, Su Y, Yu G, Yang Q, Liu W, Yu W, Cai J, Chen X, Liang Y, Chen Y, Wong BH, Fu X*, Sun H*. Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins. Br J Cancer. 2016 Mar 1;114(5):532-44. 4. Zhang Z, He L, Hu S, Wang Y, Lai Q, Yang P, Yu Q, Zhang S, Xiong F, Simsekyilmaz S, Ning Q, Li J, Zhang D, Zhang H, Xiang X, Zhou Z, Sun H*, Wang CY*. AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle/Syk/Card9 signaling along with the Nlrp3 inflammasome assembly. Am J Transl Res. 2015 Oct 15;7 (10):1812-25. （Equal corresponding author） 5. Jiang SH, Chen YJ, Wang M, Yin YL, Pan YF, Gu BL, Yu GJ, Li YM, Barry Hon Cheung Wong, Liang Y, Sun H*, A Novel lectin from Agrocybe aegerita with high binding selectivity toward terminal N-acetylglucosamine. Biochemical Journal, 2012, Apr 15;443(2):369-78 6. Yang Q, Yin Y, Yu G, Jin Y, Ye X, Shrestha A, Liu W, Yu W, Sun H*. A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris. Int J Biol Macromol. 2015 Sep;80:385-91. 7. Jin Y, Che T, Yin Y, Yu G, Yang Q, Liu W, Ye X, Yu W, Alok S, Chen Y, Wong BH, Cheng P, Sun H*. Lethal protein in mass consumption edible mushroom Agrocybe aegerita linked to strong hepatic toxicity. Toxicon. 2014 Nov;90:273-85. 8. Liang Y, Lin JC, Wang K, Chen YJ, Liu HH, Luan R, Jiang S, Che T, Zhao Y, Li DF, Wang DC, Guo L, Sun H*. A nuclear ligand MRG15 involved in the proapoptotic activity of medicinal fungal galectin AAL (Agrocybe aegerita lectin). Biochim Biophys Acta. 2010; 1800(4): 474-480