黄健 - 武汉大学 - 生命科学学院

个人简介

学习经历 1986-1990年武汉大学生命科学学院生物化学专业　获学士学位 1993-1996年武汉大学生命科学学院生物化学专业　获硕士学位 1996-1999年武汉大学生命科学学院微生物学专业　获博士学位主要工作经历与任职情况讲　师　1999-2001年　武汉大学生命科学学院助　研　1999-2000年　香港理工大学应用生物及化学学系博士后　2001-2003年　美国肯塔基大学生物化学学系副教授　2001-2009年　武汉大学生命科学学院教　授　2009-现　在　武汉大学生命科学学院

研究领域

1. 阿尔兹海默症发病机制以及雌激素神经保护的研究。 2. 抗肿瘤药物筛选及其抗肿瘤机制的研究。

近期论文

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1.Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Yan ping*, Hai-Bing Zhou*, Jian Huang*. A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. Eur J Pharmacol. 828:67-79. (2018). 2. Junjie Luo, Zhiye Hu, Yuan Xiao, Tongxin Yang, Chune Dong, Jian Huang and Hai-Bing Zhou*. Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy. Med. Chem. Commun. 8(7): 1485-1497.（2017）. 3. Yuzhi Lu, Jun Li, Chun-E Dong, Jian Huang, Hai-Bing Zhou*,Wei Wang*. Recent advances in gossypol derivatives and analogs: a chemistry and biology view. Future Med Chem. 9(11):1243-1275.（2017）. 4. Lu Yang, Zhiye Hu, Junjie Luo, Chu Tang, Silong Zhang, Wentao Ning, Chune Dong, Jian Huang ,Xianjun Liu, Hai-Bing Zhou. Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy. Bioorg Med Chem.1;25(13):3531-3539.（2017）. 5. Lijuan Deng, Chen Cheng, Jun Wu, Caihua Wang, Hai-Bing Zhou*, Jian Huang*. Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells. Neurochem Res. 42(8):2246-2256.（2017）. 6. Xue Wang, Nan Zheng, Jing Dong, Xuming Wang, Lijiang Liu*, Jian Huang*. Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells. J Steroid Biochem Mol Biol.171:318-327.(2017). 7. Silong Zhang, Zhiyong Wang, Zhiye Hu, Changhao Li, Chu Tang, Kathryn E. Carlson, Junjie Luo, Chune Dong, John A. Katzenellenbogen, Jian Huang* and Hai-Bing Zhou*. Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands. Chem Med Chem. 12(3):235-249.(2017). 8. Huiping Xie, Zhimin Xiao and Jian Huang*. C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively. J Mol Neurosci.59(3):334-42. (2016). 9. Changhao Li,Chu Tang,Zhiye Hu,Chenxi Zhao,Chenlu Li,Silong Zhang,Chune Dong,Hai-Bing Zhou and Jian Huang*. Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy. Bioorg Med Chem.24(13):3062-74. (2016). 10. Can Huang, Peng Yuan, Jun Wu and Jian Huang*. Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells. Neuroscience.319: 9-22.(2016). 11. Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*, Jian Huang* and Hai-Bing Zhou*. Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer. J Med Chem. 58(11):4550-72. (2015). 12. Dan Tong, Janice Ortega, Christine Kim, Jian Huang, Liya Gu, Guo-Min Li. Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation. J Biol Chem. 290(23): 14536–14541. (2015). 13. Huijun Zeng, Pan Huang, Xue Wang, Jun Wu, Min Wu, Jian Huang*. Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. Neuroscience. 294:172-81. (2015). 14. Nan Zheng, Peng Yuan, Changhao Li, Jun Wu, Jian Huang*. Luteolin Reduces BACE1 Expression through NF-κB and Estrogen Receptor Mediated Pathways in HEK293 and SH-SY5Y Cells. J Alzheimers Dis. 45: 659–671. (2015). 15. Caihua Wang, Changhao Li, Haibing Zhou and Jian Huang*. High-Throughput Screening Assays for Estrogen Receptor by Using Coumestrol, a Natural Fluorescence Compound. J Biomol Screen. 19(2):253-8. (2014). 16. Zhimin Xiao, Can Huang, Jun Wu, Li Sun, Wei Hao, Lai K. Leung, Jian Huang*. The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity on human neuroblastoma SH-SY5Y cells. Eur J Pharmacol. 721: 286–293 (2013). 17. Wenjuan Tan, Tsz Yan Wong, Yanfei Wang, Jian Huang, Lai K. Leung*. CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Mol Cell Endocrinol. 15;375(1-2):106-12. (2013). 18. Nelson L. S. Chan, Jinzhen Guo, Tianyi Zhang, Guogen Mao, Caixia Hou, Fenghua Yuan, Jian Huang, Yanbin Zhang, Jianxin Wu, Liya Gu, and Guo-Min Li*. Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions. J Biol Chem. 288(21): 15015–15022, (2013).