个人简介
Euducation: 1998 – 2003 中科院上海生命科学研究院生化与细胞所 博士 1994 – 1998 北京大学化学与分子工程学院 本科 Research Experience: 2011.12-至今 武汉大学生命科学院 教授 2010.11-2011.11 美国普渡大学生物化学系 研究科学家 2006.11-2010.10 美国普渡大学生物化学系 博士后 2004.2- 2006.10 美国斯坦福大学生物系 博士后
研究领域
研究表观遗传学、基因表达调控和细胞分裂、增殖及分化相关联的基础问题。
近期论文
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1) Cheng, X., Hao, Y., Shu,W., Zhao, M., Zhao, C., Wu, Y., Peng, X., Yao, P., Xiao, D., Qing, G., Pan, Z., Yin, L., Hu, D.*, Du, H.N.* (2017) Cell cycle-dependent Degradation of the Methyltransferase SETD3 Suppresses Cell Proliferation and Liver Tumorigenesis. J Biol. Chem. (coming soon) 2) Li, F., Zheng, L.D., Chen, X., Zhao, X.L., Briggs, S.D., Du, H.N*. (2017) Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA Damage Stress. Nucleic Acids Res. DOI:10.1093/nar/gkx129 3) Hu J.Y., Zhang D.L., Liu X.L., Li X.S., Cheng X.Q., Chen J., Du H.N., Liang Y*. (2016) Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells. Biochim Biophys Acta. 1863: 414-427. 4) Wang H.Y., Li Y., Xue T., Cheng N., Du, H.N.* (2016) Construction of a series of pCS2+ backbone-based Gateway vectors for overexpressing various tagged proteins in vertebrates. Acta Biochim Biophys Sin. 48: 1128-1134. 5) Xiao D, Yue M, Su H, Ren P, Jiang J, Li F, Hu Y, Du, H.N., Liu H, Qing G*. (2016) Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival. Mol Cell. 2016 Nov 3;64(3):493-506. 6) Du, H.N.* (2012) Transcription, DNA damage and beyond: the roles of histone ubiquitination and deubiquitination. Curr Prot & Pept Sci 13:447-466.