徐丹 - 武汉大学 - 基础医学院

个人简介

6、学习经历： 2010.07 -2012.06 武汉大学，生命科学学院发育生物学，博士后 2007.09 -2010.06 武汉大学，基础医学院药理学系，博士 2005.09-2007.06 武汉大学，基础医学院药理学系，硕士 2000.09-2005.06 武汉大学，医学院临床医学专业，学士 7、主要工作经历与任职： 2013.01-至今武汉大学，基础医学院药理学系，副教授 2016.01-2017.01 美国匹兹堡大学，遗传药理中心，访问学者 2011.01 -2012.12 武汉大学，基础医学院药理学系，讲师 2010.07-2010.12 武汉大学，基础医学院药理学系，助教

研究领域

专注于胎源性疾病的宫内编程机制及药物防治研究。前期研究系统证实了孕期地塞米松、尼古丁、咖啡因暴露所致宫内发育迟缓（IUGR）子代成年下丘脑-垂体-肾上腺（HPA）轴相关疾病（如脂肪肝、高胆固醇血症、躁郁症、学习记忆障碍、卵巢早衰）易感的胎儿起源现象，创新性提出宫内神经内分泌代谢编程改变是引起IUGR仔鼠成年HPA轴相关疾病易感的胎儿起源机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1) Xu D, Luo HW, Hu W, Hu SW, Yuan C, Wang GH, Zhang L, Yu H, Magdalou J, Chen LB, Wang H. Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring. FASEB J. 2018;32(10):5563-5576. 2) Lu J, Jiao Z, Yu Y, Zhang C, He X, Li Q, Xu D*, Wang H*. Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure. Cell Death Dis. 2018;31;9(6):659. 3) Lv F, Wan Y, Chen YX, Pei LG, Luo DJ, Fan GL, Luo MC, Xu D*, Wang H*. Prenatal dexamethasone exposure induced ovarian developmental toxicity and a transgenerational inheritance effect in rat offspring. Endocrinology. 2018;159(3):1401-1415. 4) He B, Xu D*, Zhang C, Zhang L, Wang H*. Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming. Toxicol Res. 2018;7(2):293-306. 5) Xu D*, Zhang C, He X, Guo ZJ, Hu DC, Lu J, Cheng SY, Wang H*. High expression of hippocampal glutamic acid decarboxylase 67 mediates hypersensitivity of the hypothalamic-pituitary-adrenal axis in response to prenatal caffeine exposure in rats. Toxicol Lett. 2018;283:39-51. 6) Dong WT, Xu D*, Hu ZW, He X, Guo ZJ, Jiao ZX, Yu Y, Wang H. Low-functional programming of the CREB/BDNF/TrkB pathway mediates cognitive impairment in male offspring after prenatal dexamethasone exposure. Toxicol Lett. 2018;283:1-12. 7) He X, Lu J, Dong WT, Jiao ZX, Zhang C, Yu Y, Zhang ZH, Wang H, Xu D*. Prenatal nicotine exposure induces HPA axis-hypersensitivity in offspring rats via the intrauterine programming of up-regulation of hippocampal GAD67. Arch Toxicol. 2017;91(12):3927-3943. 8) Lu J, Wen YX, Zhang L, Zhang C, Zhong WH, Zhang L, Yu Ying, Chen LB, Xu D*, Wang H*. Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic-pituitary-adrenal axis in female offspring rats fed with post-weaning high-fat diet. Toxicol Res. 2015;4(5):1238-1249. 9) Xu D, Bai J, Zhang L, Shen L, Wang LL, Liu ZF, Xia LP, Wang H. Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats. Toxicol Res. 2015; 4(1):112-120. 10) Zhang C, Xu D, Luo H, Lu J, Liu L, Ping J, Wang H. Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration. Toxicology. 2014;325C:74-84.