平洁 - 武汉大学 - 基础医学院

个人简介

6、学习经历： 2003.09 ~ 2007.11 武汉大学医学部药理学系硕博连读，获医学博士学位 1998.09 ~ 2003.07 武汉大学，获医学学士学位 7、主要工作经历与任职： 2016.8-2017.9 美国明尼苏达大学，访问学者 2013.6 ~至今武汉大学基础医学院药理系，博导 2010.12 ~至今武汉大学基础医学院药理系，副教授、硕导 2009.3-2009.6 美国国防医科大学（USUHS），访问学者 2007.12 ~ 2010.11 武汉大学基础医学院药理系，讲师

研究领域

研究调节性T细胞、巨噬细胞在脂肪肝、糖尿病等代谢性疾病发生发展中的作用及其分子机制，为疾病的早期诊断和药物防治提供靶标。首次提出肝脏Tregs细胞数量和功能抑制发生在单纯性脂肪肝阶段甚至其形成之前，其诱导肝实质细胞IR，是参与脂肪肝发生发展的始动因素，有助于人们更全面的认识免疫系统和代谢疾病之间的联系。

近期论文

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1. Wu DM, Wen X1, Qu W, Liu HX, Ma LP, Chen T, Ping J*. Prenatal caffeine ingestion induces long-term alterations in scavenger receptor class B type I expression and glucocorticoid synthesis in adult male offspring rat adrenals. Food Chem Toxicol. 2018; 26(120): 24-31. 2. Wu DM, Yan YE, Ma LP, Liu HX, Qu W, Ping J*. Intrauterine growth retardation-associated syncytin b hypermethylation in maternal rat blood revealed by DNA methylation array analysis. Pediatr. Res. 2017; 82(4): 704-711. 3. Liu HX, Hou LF, Chen T, Qu W, Liu S, Yan HY, Wen X, Ping J*. Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in adult female rat offspring. Reproductive Toxicology 2017; 74: 212-218. 4. Liu HX, Jiang AF, Chen T, Qu W, Yan HY, Ping J*. Reproductive Toxicity of T Cells in Early Life: Abnormal Immune Development and Postnatal Diseases. Current Drug Targets, 2017, 18, 1132-1141. 5. Qu W, Ma LP, Yan HY, Liu S, Liu HX, Chen T, Hou LF, Ping J*. Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation results in declined mature T cells in rat fetal thymus. Environmental Toxicology and Pharmacology, 2017; 56: 50-55. 6. Chen T, Yan YE, Liu S, Liu HX, Yan HY, Hou LF, Qu W, Ping J*. Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice. Scientific Reports, 2016; 6: 39013. 7. Chen T, Liu HX, Yan HY, Wu DM, Ping J*. Developmental origins of inflammatory and immune diseases. Molecular Human Reproduction, 2016; 22(8):858-65. 8. Wu DM, He Z, Chen T, Liu Y, Ma LP, Ping J*. DNA hypermethylation of acetoacetyl-CoA synthetase contributes to inhibited cholesterol supply and steroidogenesis in fetal rat adrenals under prenatal nicotine exposure. Toxicology. 2016; 340: 43-52. 9. Wu DM, He Z, Ma LP, Wang LL, Ping J*, Wang H. Increased DNA methylation of scavenger receptor class B type I contributes to inhibitory effects of prenatal caffeine ingestion on cholesterol uptake and steroidogenesis in fetal adrenals. Toxicol. Appl. Pharmacol. 2015; 285(2): 89-97. 10. Ping J, Wang JF, Liu L, Yan YE, Liu F, Lei YY, Wang H. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Toxicology 2014; 321: 53-61.