敖英 - 武汉大学 - 基础医学院

个人简介

学习经历： 2013.04~2014.04 美国匹兹堡大学，访问学者 2003.09 ~2008.07 武汉大学医学院，攻读内科学博士学位 1999.09 ~2002.07 武汉大学医学院，攻读药理学硕士学位 1993.09 ~1998.07 湖北医科大学，攻读医学学士学位主要工作经历和任职 2008.11 ~至今武汉大学医学院药理学系副教授 2003.11 ~2008.10 武汉大学医学院药理学系讲师 1998.07 ~2003.10 武汉大学医学院药理学系助教

研究领域

主要从事孕期外源物（地塞米松、咖啡因、尼古丁、乙醇等）暴露所致肾脏足细胞发育毒性和胎源性肾病发生机制研究。前期工作证实，孕期外源物暴露可导致子代肾脏肾小球硬化易感和足细胞发育毒性，机制与表遗传修饰异常所致子代肾脏及足细胞发育关键基因AT2R、KLF4等低表达编程有关。后期主要关注点是，研究孕期外源物暴露对足细胞发育关键基因表达调控的表遗传机制（组蛋白修饰、DNA甲基化、miRNA调控等）、胎源性肾脏疾病的早期预警及干预靶标。

近期论文

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1) Li Bin, ZhuY, Chen HY, Gao H, He HY, Zuo N, Pei LG, Xie W, Ao Y*, Wang Hui*. Decreased H3K9ac level of AT2R mediates the developmental origin of glomerulosclerosis induced by prenatal dexamethasone exposure in male offspring rats. Toxicology. 2018. Accepted. (*co-corresponding author) (JCR二区，IF: 3.582) 2) Zhu YN1, Zuo N1, Li B, Xiong Y, Chen HY, He HY, Sun ZX, Hu SS, Cheng H, Ao Y*, Wang H*. The expressional disorder of the renal RAS mediates nephrotic syndrome of male rat offspring induced by prenatal ethanol exposure. Toxicology. 2018; May 1; 400-401:9-19. (*co-corresponding author) (JCR二区，IF: 3.582) 3) Huang HG, Liu L, Li J, Zhu CY, Xie XY, Ao Y*, Wang H*. Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018; Apr 15; 345: 36-47. (JCR二区，IF: 3.791) 4) Li B1, Cong M1, Zhu Y, Xiong Y, Jin W, Wan Y, Zhou Y, Ao Y*, Hui Wang*. Indole-3-carbinol induces apoptosis of hepatic stellate cells through K63 de-ubiquitination of RIP1 in rats. Cellular Physiol Biochem. 2017;41(4):1481-1490. (*co-corresponding author) (二区，IF: 5.104) 5) Ao Y, Sun Z, Hu S, Zuo N, Li B, Yang S, Xia L, Wu Y, Wang L, He Z, Wang H*. Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):128-38. (二区，IF:3.705) 6) Sun Z1, Hu S1, Zuo N, Yang S, He Z, Ao Y*, Wang H*. Prenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring. Toxicol res. 2015; 4: 1045-1058. (*co-corresponding author) (二区，IF:3.983) 7) Ao Y, Mich-Basso JD, Lin B, Yang L. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS One. 2014 Jun 20;9(6):e100417. (二区，IF:3.234)