个人简介
学习经历: 1996.9-2001.6,武汉大学,医学部,临床医学专业 学士 2001.7-2003.6,武汉大学, 基础医学院,免疫学专业 硕士 2003.7-2006.6,武汉大学, 基础医学院,病原生物学 博士 主要工作经历与任职: 2006.7 -2011.12,武汉大学,基础医学院,免疫学系, 讲师 2010.10-2011.10,美国University of Michigan, Medical school,访问学者 2011.12 -至今,武汉大学, 基础医学院,免疫学系,副教授
研究领域
主要从事细菌感染免疫、免疫调节机制的相关研究,开展了感染性疾病和相关肿瘤的抗菌/瘤小分子或疫苗的工作。
近期论文
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1) Pan Q, Luo F, Liu M, Zhang XL*. Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases. J Infect. 2018 (2):83-98. 2) Tang XL, Yuan CH, Ding Q, Zhou Y, Pan Q*, Zhang XL*. Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2017 May;104:95-106. doi: 10.1016/j.tube.2017.03.010. Epub 2017 Mar 29. PMID: 28454656 3) Pan Q, Yan J, Liu Q, Yuan C, Zhang XL*. A single-stranded DNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression. Microbiol Immunol. 2017 Feb;61(2):92-102. 4) Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. A single ssDNA aptamer binding to ManLAM of BCG enhances immunoprotective effects against Tuberculosis. J Am Chem Soc. 2016;138(36):11680-9. doi: 10.1021/jacs.6b05357.(共同第一作者)(IF: 13) 5) Pan Q, Li Q, Liu S, Ning N, Zhang X, Xu Y, Chang AE, Wicha MS*. Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells. 2015;33(7):2085-92. (IF: 7.1) 6) Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 2014;22(5):940-51. (IF: 7.1) 7) Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. Ficolin-2 Defends against Virulent Mycobacteria Tuberculosis Infection In Vivo, and Its Insufficiency Is Associated with Infection in Humans. PLOS ONE 2013, 8 (9):e73859. (IF:3.8) 8) Liu M, Pan Q, Luo FL, Meyers C, Zhang XL*. Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs. Wuhan University Journal of Natural Sciences. 2013; 18: 1-8.(共同第一作者)