霍文哲 - 武汉大学 - 基础医学院

个人简介

学习经历 2004-2006 美国宾夕法尼亚大学医学院公共卫生硕士(M.P.H.) 1988-1991 美国宾夕法尼亚大学Wistar研究所博士后(Postdoctoral Fellow) 1986-1988 美国宾夕法尼亚大学医学院费城儿童医院传染科临床医学博士研究员(M..D. Fellow) 1983-1986 武汉大学人民医院儿科住院医生(Resident) 1980-1983 武汉大学医学院(原湖北医学院)儿科系医学硕士(M.S.) 1975-1979 武汉大学医学院(原湖北医学院)医学学士(B.S.) 主要工作经历与任职 2015-至今武汉大学基础医学院/病毒学国家重点实验室教授 (Professor) 2010-2015 武汉大学动物实验中心/ABSL-III实验室主任/教授(Director /Professor) 2009-至今美国天普大学医学院病理系终身正教授(Tenure Professor) 2009-至今美国天普大学医学院解剖及细胞生物系正教授(Professor) 2002-2009 美国宾夕法尼亚大学医学院费城儿童医院传染及免疫科病毒室主任(Director) 2005-2009 美国宾夕法尼亚大学医学院儿科系正教授(Professor) 1998-2005 美国宾夕法尼亚大学医学院儿科系副教授(Associate Professor) 1993-1998 美国宾夕法尼亚大学医学院儿科系助理教授(Assistant Professor)

研究领域

1. 天然免疫与艾滋病毒/肝炎病毒感染机制的研究 2. 吸毒与艾滋病毒/丙肝病毒感染的研究 3. 抗病毒天然药物的研究

近期论文

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Guo M, Xian Q, Rao Y, Zhang J, Wang Y, Huang Z, Wang X, Bao R, Zhou L, Liu J, Tang Z, Guo D, Qin C, Li J, and Ho W, SIV infection facilitates Mycobacterium tuberculosis infection of Rhesus Macaques.FrontMicrobiol, 2017. 7: 2174. Zhou Y, Wang X, Sun L, Zhou L, Ma TC, Song L, Wu JG, Li JL, and Ho WZ, Toll-like receptor 3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes.Faseb J,2016, 30: 4132. Ma TC, Zhou RH, Wang X, Li JL, Sang M, Zhou L, Zhuang K, Hou W, Guo DY, and Ho WZ, Soybean-derived Bowman-Birk Inhibitor （BBI） Inhibits HIV Replication in Macrophages.Sci Rep, 2016, 6: 34752. Liu J, Xiao Q, Zhou R, Wang Y, Xian Q, Ma T, Zhuang K, Zhou L, Guo D, Wang X, Ho WZ, and Li J, Comparative Analysis of Immune Activation Markers of CD8+ T Cells in Lymph Nodes of Different Origins in SIV-Infected Chinese Rhesus Macaques.Front Immunol, 2016, 7: 371. Xiao Q, Li J, Yu Q, Bao R, Liu J, Liu H, Zhou L, Xian Q, Wang Y, Cheng-Mayer C, Ho WZ, and Zhuang K, Distinct Compartmentalization in the CNS of SHIVKU-1-Infected Chinese Rhesus Macaque Is Associated With Severe Neuropathology.J Acquir Immune Defic Syndr, 2015, 70: e168. Wang X, Ma TC, Li JL, Zhou Y, Geller EB, Adler MW, Peng JS, Zhou W, Zhou DJ, and Ho WZ, Heroin inhibits HIV-restriction miRNAs and enhances HIV infection of macrophages.Front Microbiol, 2015, 6: 1230. Pena JC and Ho WZ, Monkey models of tuberculosis: lessons learned.Infect Immun, 2015, 83: 852. 8. Dai M, Wang X, Li JL, Zhou Y, Sang M, Liu JB, Wu JG, and Ho WZ, Activation of TLR3/interferon signaling pathway by bluetongue virus results in HIV inhibition in macrophages.Faseb J, 2015, 29: 4978. Zhang J, Xian Q, Guo M, Huang Z, Rao Y, Wang Y, Wang X, Bao R, Evans TG, Hokey D, Sizemore D, and Ho WZ, Mycobacterium tuberculosis Erdman infection of rhesus macaques of Chinese origin.Tuberculosis, 2014, 94: 634. Sang M, Liu JB, Dai M, Wu JG, and Ho WZ, Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques.AntiviralRes, 2014, 112: 103. Zhou Y, Guo M, Wang X, Li J, Wang Y, Ye L, Dai M, Zhou L, Persidsky Y, and Ho W, TLR3 activation efficiency by high or low molecular mass poly I:C.InnateImmun, 2013, 19: 184. Zhou Y, Bao R, Haigwood NL, Persidsky Y, and Ho WZ, SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans.Retrovirology, 2013, 10: 89. Wang Y, Ye L, Wang X, Li J, Song L, and Ho W, Retinoic acid inducible gene-I （RIG-I） signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes.InnateImmun, 2013, 19: 193. Wang Y, Wang X, Li J, Zhou Y, and Ho W, RIG-I activation inhibits HIV replication in macrophages.JLeukocBiol, 2013, 94: 337. Wang Y, Li J, Wang X, Ye L, Zhou Y, and Ho W, Induction of interferon-lambda contributes to Toll-like receptor-3-activated hepatic stellate cell-mediated hepatitis C virus inhibition in hepatocytes.JViralHepatitis, 2013, 20: 385. Wang Y, Li J, Wang X, Sang M, and Ho W, Hepatic stellate cells, liver innate immunity, and hepatitis C virus.J GastroenterolHepatol, 2013, 28 Suppl 1: 112. Li J, Wang Y, Wang X, Ye L, Zhou Y, Persidsky Y, and Ho W, Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages.Blood, 2013, 121: 2934. Ye L, Li J, Zhang T, Wang X, Wang Y, Zhou Y, Liu J, Parekh HK, and Ho W, Mycophenolate mofetil inhibits hepatitis C virus replication in human hepatic cells.VirusResearch, 2012, 168: 33. Wang X, Wang Y, Ye L, Li J, Zhou Y, Sakarcan S, and Ho W, Modulation of intracellular restriction factors contributes to methamphetamine-mediated enhancement of acquired immune deficiency syndrome virus infection of macrophages.CurrHIVRes, 2012, 10: 407.