乐江 - 武汉大学 - 基础医学院

个人简介

学习经历： 1993.09~1998.07 湖北医科大学，攻读学士学位 1999.09~2001.07 武汉大学，攻读硕士学位 2001.09~2004.06 武汉大学，攻读博士学位 2005.07~2008.01 加拿大多伦多大学，博士后 2015.04~2016.04 美国健康卫生研究院，访问学者主要工作经历与任职： 1998.07~2003.12武汉大学医学院药理学系，助教 2004.01~2006.12武汉大学医学院药理学系，讲师 2007.01~2009.12武汉大学医学院药理学系，副教授 2010.01~至今武汉大学医学院药理学系，教授 2009.06~至今武汉大学医学院药理学系，博导

研究领域

应用分子生物学、现代分析化学、药效学与药代学结合模型等多种手段，研究内源性和外源性物质代谢规律，从而深入认识外源物之间、外源物和内源物之间的相互作用；研究脑药物代谢酶对中枢活性物质的代谢失活及活化作用，并从代谢角度揭示药物代谢酶在神经系统疾病的病理变化过程中的作用。研究结果将深入揭示药物代谢酶的生物学功能，并有助于为相关疾病治疗提供新思路和新靶标。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang F, Li J, Na S, Wu J, Yang Z, Xie X, Wan Y, Li K, Yue J*. The Involvement of PPARs in the Selective Regulation of Brain CYP2D by Growth Hormone. Neuroscience. 2018 May 21; 379: 115-125. doi: 10.1016/j.neuroscience.2018.03.009. 2. Yueran Li, Jinhua Wu, Xuming Yu, Shufang Na, Ke Li, Zhe-Qiong Yang, Xianfei xie, Jing Yang, and Jiang Yue*. The protective role of brain CYP2J in Parkinson’s disease models. Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 2917981. 3. Na S, Li J, Zhang H, Li Y, Yang Z, Zhong Y, Dong G, Yang J, Yue J*. The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation. Toxicology. 2017 Apr 3;385:18-27. 4. Liu M, Zhu Q, Wu J, Yu X, Hu M, Xie X, Yang Z, Yang J, Feng YQ, Yue J*. Glutamate affects the production of epoxyeicosanoids within the brain: The up-regulation of brain CYP2J through the MAPK-CREB signaling pathway. Toxicology. 2017 Apr 15;381:31-38. 5. Li J, Xie M, Wang X, Ouyang X, Wan Y, Dong G, Yang Z, Yang J, Yue J*. Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol. Br J Pharmacol. 2015; 172: 4639-4654. 6. Furong Zhang, Xuming Yu, Chunyan He, XiufangOuyang, Jinhua Wu, Jie Li, Junjie Zhang, XuejiaoDuan,Yu Wan, Jiang Yue*. Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart. Toxicology and Applied Pharmacology 2015; doi:10.1016/j.taap.2015.10.011 7. Yuntao Bing, Siying Zhu, Kun Jiang, Guicheng Dong, Jie Li, Zheqiong Yang, Jing Yang, Jiang Yue*. Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke. Biochemical Pharmacology 2014; 87: 636-649. 8. Xiaoshuang Wang, Jie Li, Guicheng Dong, Jiang Yue*. The endogenous substrates of brain CYP2D. European Journal of Pharmacology 2014; 724: 211-218. 9. Yanjun Zhong, Guicheng Dong, Haiguang Luo, Jie Cao, Chang Wang, Jianyuan Wu, Yu-Qi Feng, Jiang Yue*. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology 2012(302): 275-284.