个人简介
学习经历: 2008.3-2008.4 美国University of South Alabama访问学者 2007.3-2007.4 美国University of South Dakota访问学者 2001-2004 法国 Nancy第一大学医学院 生物工程博士 2000-2003 武汉大学医学院内科学心血管病生 医学博士 1999.12-2000.3 法国 Nancy第一大学医学院 访问学者 1994-1997 湖北医科大学病理生理学硕士学位 主要工作经历与任职: 2013-至今 武汉大学医学院病理生理教研室 副主任 2010-2014 武汉大学医学结构生物学研究中心 副主任 2006-至今 武汉大学医学院病理生理教研室 教授 博导 2001-2006 武汉大学医学院病理生理教研室 副教授 硕导 1998-2001 武汉大学医学院病理生理教研室 讲师
研究领域
从事肿瘤分子病理与病理生理、心血管病理生理研究近20年,主要从细胞骨架调节的角度,在信号通路、基因表达调控、表观修饰层面研究肿瘤侵袭转移的分子调控机制,从组蛋白修饰和非编码RNA水平探索新的治疗靶点和标志物。
近期论文
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1) Xiang Ying, Yan Kai, Zheng Qian, Ke Haiqiang, Cheng Jie, Xiong Wenjun, Shi Xin, Wei Lei, Zhao Min, Yang Fei, Wang Ping, Lu Xing, Fu Li, Lu Xuemei* and Li Feng*. Histone demethylase KDM4B promotes DNA damage by activating longinterspersed nuclear element-1 (LINE-1). Cancer Reseach. Accepted.(SCI, IF=9.13) 一区 2) Su Zijie#, Song Jiaxing#, Wang Zhongyuan#, Zhou Liang, Xia Yuqing, Yu Shubin, Qi Sun, Liu Shanshan, Zhao Liang, Li Shiyue, Wei Lei, Dennis A. Carson*, and Lu Desheng*. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci USA. 2018 Aug 7; 115(32): E7522–E7531. (IF=9.504) 一区top 3) Li Kai#, Ma Yanbin#, Zhang Zun#, Tian Yihao, Xu Xiaolong, He Yanqi, Xu Liu, Gao Yang, Pan Wenting, Song Wenjing, He Xin, and Wei Lei*. Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β-catenin signaling pathway in breast cancer. Cancer Med. 2018 Aug; 7(8): 3875–3888. (IF=3.202) 三区 4) Li Kai#, Xu Xiaolong#, He Yanqi#, Tian Yihao, Pan Wenting, Xu Liu, Ma Yanbin, Gao Yang, Gao Jingbo, Qi Yuwen , Wei Lei and Zhang Jingwei*. P21-activated kinase 7 (PAK7) interacts with and activates Wnt/beta-catenin signaling pathway in breast cancer. Journal of Cancer 2018, 9(10):1821-1835(SCI, IF=3.249) 三区 5) Siyu Xia, Jing Feng, Ke Chen, Yanbing Ma, Jing Gong, Fangfang Cai, Yuxuan Jin, Yang Gao, Linjian Xia, Hong Chang, Lei Wei, Leng Han and Chunjiang He, CSCD: a database for cancer-specific circular RNAs. Nucleic Acids Research, 2017. doi: 10.1093/nar/gkx863 (SCI, IF= 10.161) 一区 6) Zhongyuan Wang, Bo Li, Liang Zhou, Shubin Yu, Zijie Su, Jiaxing Song, Qi Sun, Ou Sha,Xiaomei Wang, Wenqi Jiang, Karl Willert, Lei Wei, Dennis A. Carson, and Desheng Lu*. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. PNAS 2016 113 (46) 13150-13155 (SCI, IF=9.423) 一区top 7) Pengchao Hu, Ying Wang, Yan Zhang, Hui Song, Fangfang Gao, Hongyi Lin, Zhihao Wang, Lei Wei* and Fang Yang* Novel Mononuclear Ruthenium(II) Complexes as Potent and Low-toxicity Antitumour Agents Synthesis, Characterization. Biological Evaluation and Mechanism of Action. RSC Adv., 2016,6(36):, 29963-29976 (SCI, IF= 3.289) 三区 8) Liu Min, Qin Jian, Hao Yarong, Liu Min, Luo Jun, Luo Tao, Wei Lei *. Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes: Involvement of ROS-ERK and NF-κB Pathways. Oxidative Medicine and Cellular Longevity. 2013 (2013), Article ID 782497, (SCI, IF= 3.363) 三区 9) Wang Jing, Zhang Jingwei△, Wu Junzhu, Daji Luo, Su Ke, Shi Wentao, Liu Jian, Tian Yihao, Wei Lei*. MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein. European Journal of Cancer. 2012, 48(12):1904-1913. (△并列第一作者,SCI, IF= 7.191) 二区