梁凯威 - 武汉大学 - 基础医学院

个人简介

学习经历： 2003-2007 武汉大学，生物学基地班，学士 2007-2009 武汉大学生命科学学院，生物化学与分子生物学，硕士 2012-2016 美国Stowers医学研究所，博士主要工作经历与任职 2011.6-2015.2 美国Stowers医学研究所, Predoctoral Researcher 2015.3-2018.3 美国西北大学Feinberg医学院，Research Associate (博士后) 2018.5-2018.10 美国西北大学Feinberg医学院，访问学者 2018.3-至今武汉大学基础医学院，教授

研究领域

研究遗传变异所导致的造血干细胞的恶性转化为白血病的发病机制，探索和鉴定全新的分子治疗靶标和靶向治疗策略。前期利用MLL染色体异位所导致的混合系白血病为疾病模型，取得了以下主要成果：(1)发现了炎性信号通路介导野生型MLL泛素化降解的分子机制，揭示了稳定野生型MLL可以靶向混合系白血病中MLL融合蛋白和SEC的转录依赖，提出了稳定野生型MLL蛋白作为治疗混合系白血病的新策略（Cell, 2017）；(2)首次研发了SEC抑制剂KL-1和KL-2, 发现它们抑制SEC介导的转录延伸和转录成瘾，是肿瘤转录成瘾的全新靶向治疗药物（Cell，2018）；(3)系统研究了转录辅助因子和激酶参与转录调控的具体机制以及其异常在白血病和肿瘤中的功能（Molecular Cell, 2015; MCB, 2015; JBC, 2010; Genes Dev，2012 & 2017； Cancer Cell，2018）。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. K. Liang, E. R. Smith, Y. Aoi, K. L. Stoltz, H. Katagi, A. R. Woodfin, E. J. Rendleman, S. A. Marshall, D. C. Murray, L.Wang, P. A. Ozark, R.K. Mishra, R. Hashizume, G. E. Schiltz, and A. Shilatifard, Targeting Processive Transcription Elongation Through SEC Disruption. Cell, 2018 (In press). 2. A. Volk, K. Liang, J. Zhao, X. Li, M.Bulic, S. Marshall, J.W. Taub, Y. Ge, S. Malinge, E. Bartom, A. Shilatifard, and J.D Crispino, A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis. Cancer Cell, 2018(Accepted) 3. K. Liang, A. G. Volk, J. S. Haug, S. A. Marshall, A. R. Woodfin, E. T. Bartom, J. M. Gilmore, L. Florens, M. P. Washburn, K. D. Sullivan, J. M. Espinosa, J. Cannova, J. Zhang, E. R. Smith, J. D. Crispino, and A. Shilatifard, Therapeutic Targeting of Mll Degradation Pathways in Mll-Rearranged Leukemia. Cell, 2017. 168(1-2): p. 59-72 e13. (Previewed by NEJM) 4. L. Wang, C. K. Collings, Z. Zhao, K. A. Cozzolino, Q. Ma, K. Liang, S. A. Marshall, C. C. Sze, R. Hashizume, J. N. Savas, and A. Shilatifard, A Cytoplasmic Compass Is Necessary for Cell Survival and Triple-Negative Breast Cancer Pathogenesis by Regulating Metabolism. Genes Dev, 2017. 31(20): p. 2056-2066. 5. C. C. Ebmeier, B. Erickson, B. L. Allen, M. A. Allen, H. Kim, N. Fong, J. R. Jacobsen, K. Liang, A. Shilatifard, R. D. Dowell, W. M. Old, D. L. Bentley, and D. J. Taatjes, Human Tfiih Kinase Cdk7 Regulates Transcription-Associated Chromatin Modifications. Cell Rep, 2017. 20(5): p. 1173-1186. 6. K. Liang, A. R. Woodfin, B. D. Slaughter, J. R. Unruh, A. C. Box, R. A. Rickels, X. Gao, J. S. Haug, S. L. Jaspersen, and A. Shilatifard, Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol Ii Via Transcriptional Elongation Control in Mitosis. Mol Cell, 2015. 60(3): p. 435-45. (封面文章) 7. K. Liang, X. Gao, J. M. Gilmore, L. Florens, M. P. Washburn, E. Smith, and A. Shilatifard, Characterization of Human Cyclin-Dependent Kinase 12 (Cdk12) and Cdk13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and Rna Processing. Mol Cell Biol, 2015. 35(6): p. 928-38. 8. H. M. Herz, M. Mohan, A. S. Garruss, K. Liang, Y. H. Takahashi, K. Mickey, O. Voets, C. P. Verrijzer, and A. Shilatifard, Enhancer-Associated H3k4 Monomethylation by Trithorax-Related, the Drosophila Homolog of Mammalian Mll3/Mll4. Genes Dev, 2012. 26(23): p. 2604-20. 9. K. Liang#, L. Yang#, C. Yin, Z. Xiao, J. Zhang, Y. Liu, and J. Huang, Estrogen Stimulates Degradation of Beta-Amyloid Peptide by up-Regulating Neprilysin. J Biol Chem, 2010. 285(2): p. 935-42.