何小华 - 武汉大学 - 基础医学院

个人简介

学习经历： 1985.09~1990.07 湖北医科大学，攻读学士学位 1994.09~1997.07 湖北医科大学，攻读硕士学位 1997.09~2000.06 华中科技大学，攻读博士学位主要工作经历与任职： 1990.07~1994.09 广州军区武汉总医院，住院医师 2000.07~2002.07 武汉大学生命科学学院，博士后研究 2002.07~2005.09 广州军区武汉总医院，副主任医师，副教授，硕导 2005.09~2006.11 澳大利亚悉尼大学，访问学者 2006.11~2007.11 武汉大学病理生理学教研室，副教授，硕导 2007.11~至今武汉大学病理生理学教研室，教授，博导

研究领域

主要从事神经系统离子通道病的发病机制和防治研究，利用生物信息学、分子生物学、神经电生理等技术平台，揭示KCNQ、Kv1.3等离子通道与癫痫、多发性硬化症等神经系统疾病发生、发展的关系，并结合分子流行病学及临床研究，发现针对癫痫、多发性硬化症等神经系统离子通道病的新机制、新靶标。同时，针对新发现的离子通道药物靶标开展药物研发，基于我国特有动物多肽毒素资源，筛选、鉴定特异性作用于疾病相关膜通道及受体的多肽毒素，进一步开发新的具有自主知识产权及重要药用前景的多肽毒素。

近期论文

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1. Kuang J, Song W, Yin J, Zeng X, Han S, Zhao YP, Tao J, Liu CJ*, He XH*. Zhang XZ. iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma. Advanced Functional Materials, 2018, 28(17) DOI: 10.1002/adfm.201800025 2. Yuan XL, Zhao YP, Huang J, Liu JC, Mao WQ, Yin J, Peng BW, Liu WH, Han S*, He XH*. A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis. CNS Neurosci Ther, 2018, DOI: 10.1111/cns.12848 3. Liu YL, Hou BH, Zhang YS, Fan YT, Peng BW, Liu WH, Han S, Yin J*, He XH*. Anticonvulsant agent DPP4 inhibitor sitagliptin downregulates CXCR3/ RAGE pathway on seizure models. Experimental Neurology, 2018,307:90-98 4. Wang ZC, Zhang YS, Fang J, Yu F, Heng DH, Fan YT, Xu J, Peng BW, Liu WH, Han S*, He XH*. Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility. Mol Neurobiol, 2017, 54(9):7343-7352 5. Zhou BF, Chu M, Xu SS, Chen X, Liu YJ, Wang ZH, Zhang FF, Han S, Yin J, Peng BW, He XH*, Liu WH*. Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells. Cell & Bioscience, 2017,7:7 6. Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. Neuropharmacology, 2015, 99: 38-50 7. Zhao YP, Huang J, Yuan XL, Peng BW, Liu WH, Han S*, He XH*. Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases. Toxins, 2015, 7(5): 1749-1764 8. Huang WX, Yu F, Sanchez RM, Liu YQ, Min JW, Hu JJ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. TRPV1 promotes the occurrence of repetitive febrile seizures by increasing the secretion of pro-inflammatory cytokines in the immature brain. Brain Behavior Immun, 2015, 48:68-77 9. Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. Neuropharmacology, 2015, 99:38-50 10. Heng DH, Wang ZC, Fan YT, Li L, Fang J, Han S, Yin J, Peng BW, Liu WH, He XH*. Long Term Metabolic Alterations in a Febrile Seizure Model. Int J Neurosci, 2015, 22:1-22