何立 - 武汉大学 - 基础医学院

个人简介

学习经历： 1978.09~1983.07 江西医学院医疗系本科，攻读学士学位 1986.09~1989.07 湖北医科大学人体寄生虫学专业，攻读硕士学位 1999.09~2002.06 中南大学湘雅医学院病原生物学专业，攻读博士学位 2003.09~2003.12赴日本国福岛医科大学做访问学者 2006.10~2007.10澳大利亚墨尔本大学，访问学者主要工作经历与任职： 1983.07~1986.08江西医学院附属抚州医院，医师 1989.07~1997.12 武汉大学基础医学院人体寄生虫学教研室，讲师 1998.01~2003.10 武汉大学医人体寄生虫学教研室，副教授，教研室副主任 2003.10~2004.12 武汉大学医人体寄生虫学教研室，教授、博导，教研室副主任 2005.01~2016.12 武汉大学基础医学院教授、博导，副院长 2017.01~至今武汉大学基础医学院人体寄生虫学教研室教授、博导

研究领域

主要从事医学贝类的形态学、生态学与分子分类学，主要涉及血吸虫中间宿主钉螺和并殖吸虫中间宿主的其它淡水螺类，为钉螺及拟钉螺的分类提供了大量的分子生物学证据。自20世纪 90年代后，主要从事寄生虫感染免疫学与分子寄生虫学领域的科学研究工作，重点研究血吸虫的免疫逃避机制、血吸虫感染的保护性免疫机制及血吸虫病的免疫防治。

近期论文

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1. ChenLin, ChenQingzhou, HouWei, HeLi*. High-throughput dynamic analysis of differentially expressed genes in splenic dendritic cells from mice infected with Schistosoma japonicum. IMMUNOLOGY LETTERS. 2017,184: 15-22. 2. ChenLin, HeBaohua, HouWei, HeLi*. Cysteine protease inhibitor of Schistosoma japonicum ---A parasite derived negative immunoregulatory factor. PARASITOLOGY RESEARCH. 2017, 116(3): 901-908. 3. ChenLin, ChenQing-zhou, HouWei, HeLi*. The dynamic changes of CD3e(-)CD11c(+) dendritic cells in spleens and bone marrow of mice infected with Schistosoma japonicum. PARASITOLOGY RESEARCH. 2017, 116(3): 1008-1011. 4. ZhangYing, HeYuan, HeLi*, ZongHong-ying, CaiGuobin. Expression and characterization of a phospholipid hydroperoxide glutathione peroxidase gene in Schistosoma japonicum. PARASITOLOGY. 2015, 142(13): 1595-1604. 5. Zhang Ying, He Yuan, HeLi*, Zong Hong-Ying, Cai Guo-Bin. Molecular cloning and characterization of a phospholipid hydroperoxide glutathione peroxidase gene from a blood fluke Schistosoma japonicum.MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 2015, 203(1): 5-13. 6. DengZhao-qun, QianJun, LiuFeng-qiong, LinJiang, ShaoRui, YinJia-yu, TangQin, ZhangMing, HeLi*. . Expression Level of miR-93 in Formalin-Fixed Paraffin Embedded Tissues of Breast Cancer Patients. GENETIC TESTING AND MOLECULAR BIOMARKERS. 2014, 18(5):366-370. 7. DengZhao-Qun, YinJia-Yu, TangQin, LiuFeng-Qiong, QianJun, LinJiang, ShaoRui, ZhangMing, HeLi*. Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2014, 7(3): 1166-1177. 8. XiongYuan-Huan, HeLi*. , FeiJing. Genetic variations in cytotoxic T-lymphocyte antigen-4 and susceptibility to cervical cancer. INTERNATIONAL IMMUNOPHARMACOLOGY. 2014, 18(1): 71-76. 9. XiongYuan-Huan, YuanZhen, HeLi*. Effects of estrogen on CD4(+) CD25(+) regulatory T cell in peripheral blood during pregnancy. ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE. 2013, 6(9): 748-752. 10. HeYuan, CaiGuobin, NiYonghui, LiYing, Zong Hongying), HeLi*.siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro. EXPERIMENTAL PARASITOLOGY. 2012, 132(4): 394-402