周宇 - 武汉大学 - 生命科学学院

个人简介

学习经历 1999-09－2003-06 武汉大学本科生物学基地班 2003-09－2004-09 武汉大学硕士生化与分子生物学 2004-10－2005-07 法国巴黎十一大学硕士生物信息与生物统计学 2005-09－2008-12 武汉大学博士生化与分子生物学 2005-09－2008-12 法国巴黎十一大学博士计算机 (与武汉大学联合培养）主要工作经历及任职情况 2009-07－2015-05 美国加州大学圣地亚哥分校博士后 2015-05－至今武汉大学教授 2015-08－至今武汉大学高等研究院兼职研究员

研究领域

1）开发高通量测序数据分析和可视化工具，促进大数据转换成生物学发现；2）RNA核滞留的功能元件及分子机制；3）RNA结合蛋白对非编码RNA结构与功能的调控；4）miRNA的生成加工与细胞核亚结构的关系；5）RNA转录终止调控机制及其异常在相关疾病中的作用。同时与其他国内外实验室合作，从生物信息学角度解决多种生物学问题。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Jiaqi Gu#, Ming Wang#, Yang Yang#, Ding Qiu, Yiqun Zhang, Jinbiao Ma*, Yu Zhou*, Gregory J. Hannon*, and Yang Yu*. GoldCLIP: Gel-omitted Ligation-dependent CLIP. Genomics, Proteomics & Bioinformatics, 2018, 16(2):136-143. 2. Li Jiang#, Changwei Shao#, Qi-Jia Wu#, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, Yu Zhou*, and Xiang-Dong Fu*. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nature Structural & Molecular Biology, 2017, 24:816-824. 3. Huiwu Ouyang, Kai Zhang, Kristi Fox-Walsh, Yang Yang, Chen Zhang, Jie Huang, Hairi Li, Yu Zhou*, and Xiang-Dong Fu*. The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells. Nucleic Acids Research, 2017, 45(21):12481-12495. 4. Chaoliang Wei#, Rui Xiao#, Liang Chen#, Hanwei Cui#, Yu Zhou#, Yuanchao Xue, Jing Hu, Bing Zhou, Taiki Tsutsui, Jinsong Qiu, Hairi Li, Liling Tang, and Xiang-Dong Fu*. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell, 2016, 62(6):875-889. 5. Lanfeng Wang#, Yu Zhou#, Liang Xu#, Rui Xiao#, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu & Dong Wang*. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature (2015) 523, 621–625. 6. Yu Zhou, Hai-Ri Li, Jie Huang, Ge Jin, and Xiang-Dong Fu*. Multiplex analysis of polyA-linked sequences (MAPS): an RNA-seq strategy to profile poly(A+) RNA. Methods Mol Biol (2014) 1125:169-178. 7. Shatakshi Pandit#, Yu Zhou#, Lily Shiue#, Gabriela Coutinho-Mansfield, Hairi Li, Jinsong Qiu, Jie Huang, Gene W. Yeo, Manuel Ares, Jr.* and Xiang-Dong Fu*. Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Molecular Cell (2013) 50(2), 223-235. 8. Yu Zhou#, Yann Ponty#, Stephane Vialette, Jerome Waldispuhl, Yi Zhang, and Alain Denise*. Flexible RNA design under structure and sequence constraints using formal languages. In ACM BCB - ACM Conference on Bioinformatics, Computational Biology and Biomedical Informatics. Bethesda, Washigton DC, United States, (2013). 9. Yuanchao Xue#, Yu Zhou#, Tongbin Wu, Tuo Zhu, Xiong Ji, Young-Soo Kwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu*, and Yi Zhang*. Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Molecular Cell (2009) 36(6), 996-1006. 10. Yu Zhou#, Chen Lu#, Qi-Jia Wu#, Yu Wang, Zhi-Tao Sun, Jia-Cong Deng, and Yi Zhang*. GISSD: Group I Intron Sequence and Structure Database. Nucleic Acids Research (2008) 36, D31-D37.