个人简介

EDUCATION AND PROFESSIONAL EXPERIENCE 2008-present, Assistant Professor, Department of Chemistry University of Miami 2007-2008, Visiting Assistant Professor, Department of Chemistry, University of San Francisco 2005-2007, Postdoctoral Fellow, Stanford University 2004, Ph.D. in Organic Chemistry, Georgia Institute of Technology 2000, B.S. in Chemistry, University of South Carolina AWARDS AND FELLOWSHIPS 2010-11, American Cancer Society, IRG Awardee 2005-07, Ruth L. Kirschstein NIH Postdoctoral Fellowship

研究领域

Conjugated Polymers, Novel Fluorophores, Fluorescence Based Detection Schemes, and Organic Materials.

Research in my group is in the general areas of bioorganic and materials chemistry with a specific focus on the development of fluorescent analogs of biomolecules. We design, synthesize and characterize probes targeting specific biomacromolecular structures including DNA, transmembrane proteins, enzymes and receptors. This effort incorporates several research activities including quantum chemical calculations, organic synthesis, optical spectroscopy, in vitro cellular studies, and fluorescence microscopy.

近期论文

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Wilson, J. N.; Wigenius, J.; Pitter, D. R. G.; Qiu, Y.; Abrahamsson, M.; Westerlund, F. Base Pair Sensitivity and Enhanced ON/OFF Ratios of DNA-Binding: Donor−Acceptor−Donor Fluorophores, J. Phys. Chem. B, 2013, 117, 12000-12006. Pitter, D. R. G.; Wigenius, J.; Brown, A. S.; Baker, J. D.; Westerlund, F.; Wilson, J. N. Turn-On, Fluorescent Nuclear Stains with Live Cell Compatibility, Org. Lett., 2013, 15, 1330-1333. (Highlighted in C&E News, "A Bright Idea for a Nucleus Stain" March, 2013) (Included in the ACS virtual issue: Nucleic Acids - Chemistry and Applications) Adjaye-Mensah, E.; Gonzalez, W. G.; Miksovska, J.; Wilson, J. N. Photophysical Characterization of a Benzo-Fused Analogue of Brooker’s Merocyanine: Solvent Polarity and pH Effects, J. Phys. Chem. A, 2012, 116, 12470. Wilson, J. N.; Brown, A. S.; Babinchak, W. M.; Ridge, C. D.; Walls, J. D. Fluorescent Stilbazolium dyes as probes of the norepinephrine transporter: structural insights into substrate binding, Org. Biomol. Chem. 2012, 10, 8710. Sicard, R.; Dhuguru, J.; Liu, W.; Patel, N.; Landgraf, R.; Wilson, J. N. A fluorescent reporter of ATP binding-competent receptor kinases, Bioorg. Med. Chem. Lett., 2012, 22, 5532. Smith, E. L.; Brown, A. S.; Adjaye-Mensah, E.; Wilson, J. N. “Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers.” Org. Biomol. Chem., 2012, 10, 1493. Dhuguru, J.; Gheewala, C.; Kumar, N. S. S.; Wilson, J. N. “Highly Chromic, Proton Responsive Phenyl Pyrimidones.” Org. Lett., 2011, 13, 4188-4191. Bagale, M. D.; Brown, A. S.; Carballosa Gonzalez, M. M.; Vitores, A.; Micotto, T. L.; Kumar, N. S. S.; Hentall, I. D.; Wilson, J. N. “Fluorescent reporters of monoamine transporter distribution and function.” Bioorg. Med. Chem. Lett.,2011, 21, 7387-7391. Gujrati, M. D.; Kumar, N. S. S.; Brown, A. S.; Captain, B.; Wilson, J. N. “Luminescent Charge-Transfer Complexes: Tuning Emission in Binary Fluorophore Mixtures.”, Langmuir, 2011, 27, 6554-6558. Brown, A. S.; Bernal, L. -M.; Micotto, T. L.; Smith, E. L.; Wilson, J. N. “Fluorescent Neuroactive Probes Based on Stilbazolium Dyes.” Org. Biomol. Chem., 2011, 9, 2142-2148. Kumar, S. N. S.; Gujrati, M. D.; Wilson, J. N. “Evidence of preferential ?-stacking: a study of intermolecular and intramolecular charge transfer complexes.” Chem. Commun. 2010, 46, 5464-5466. Micotto, T. L.; Brown, A. S.; Wilson, J. N. “Fluorescent mimics of 5-hydroxytryptamine based on N-alkylated derivatives of 6-hydroxycarbostyril.” Chem. Commun. 2009, 7548-7550.