加正平 - 东南大学 - 生命科学与技术研究院

研究领域

Learning and memory in mice Synaptic transmission and plasticity Genetic manipulations in mice Dendritic spine and synaptogenesis Glutamate receptors

近期论文

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Leung C, Cao F, Nguyen R, Joshi K, Aqrabawi AJ, Xia S, Cortez MA, Snead OC 3rd, Kim JC, Jia Z. (2018) Activation of entorhinal cortical projections to the dentate gyrus underlies social memory retrieval. Cell Rep. 23, 2379-2391. Zhou Z, Liu A, Xia S, Leung C, Qi J, Meng Y, Xie W, Park P, Collingridge GL, Jia Z. (2018) The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nat Neurosci. 21, 50-62. Wang Y, Zeng C, Li J, Zhou Z, Ju X, Xia S, Li Y, Liu A, Teng H, Zhang K, Shi L, Bi C, Xie W, He X, Jia Z, Jiang Y, Cai T, Wu J, Xia K, Sun ZS. (2018) PAK2 Haploinsufficiency results in synaptic cytoskeleton impairment and autism-related behavior. Cell Rep. 24, 2029-2041 Bin NR, Ma K, Harada H, Tien CW, Bergin F, Sugita K, Luyben TT, Narimatsu M, Jia Z, Wrana JL, Monnier PP, Zhang L, Okamoto K, Sugita S (2018) Crucial role of Postsynaptic Syntaxin 4 in mediating basal neurotransmission and synaptic plasticity in hippocampal CA1 neurons. Cell Rep. 23, 2955-2966. Xing G, Li M, Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. (2018) Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. Elife. 2018 Mar 14;7. pii: e30457. Jia Z, Collingridge GL. (2017) Learning about synaptic GluA3. Neuron 93, 254-256 Cao F, Zhou Z, Pan X, Leung C, Xie W, Collingridge G, Jia Z. (2017) Developmental regulation of hippocampal long-term depression by cofilin-mediated actin reorganization. Neuropharmacology 112, 66-75. Xia S, Zhou Z, Leung C, Zhu Y, Pan X, Qi J, Morena M, Hill MN, Xie W, Jia Z. (2016) p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus. Elife. 2016 Jun 14;5. pii: e14653. Leung C, Jia Z. (2016) Mouse genetic models of human brain disorders. Front Genet. 2016 Mar 23;7:40. doi: 10.3389/fgene.2016.00040. Liu A, Zhou Z, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z, Xie W. (2016) Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 212, 449-463. Todorovski Z, Asrar S, Liu J, Saw NM, Joshi K, Cortez MA, Snead OC 3rd, Xie W, Jia Z. (2015) LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB. Mol Cell Biol. 35, 1316-1328. Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W, Han J. (2013) Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci. 33, 15545-15554 Liston C, Cichon JM, Jeanneteau F, Jia Z, Chao MV, Gan WB. (2013) Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci. 16, 698-705. Asrar S, Jia Z (2013) Molecular mechanisms coordinating functional and morphological plasticity at the synapse: role of GluA2/N-cadherin interaction-mediated actin signaling in mGluR-dependent LTD. Cell Signal. 25, 397-402 Zhou, Z., Hu, J., Passafaro, M., Xie, W., and Jia, Z. (2011). GluA2 (GluR2) regulates metabotropic glutamate receptor-dependent long-term depression through N-cadherin-dependent and cofilin-mediated actin reorganization. J. Neurosci. 31, 819-833. Huang, W., Zhou, Z., Henkelman, M., Xie, W., and Jia, Z. (2011). PAK1/3 control brain size through coordinating neuronal complexity and synaptic properties. Molecular and Cellular Biology 31, 388-403. Phan, K., Hazen, V., Frendo, M., Jia, Z., and Butler, S. (2010). The BMP roof plate chemorepellent regulates the rate of commissural axonal growth. J. Neurosci. 30, 15430-40. *Yu T, *Li Z, *Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera S, Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S, Nowak NJ, Roder JC, Chen C, Bradley A, Yu YE (2010). A Mouse Model of Down Syndrome Trisomic For All Human Chromosome 21 Syntenic Regions. Human Molecular Genetics 19, 2780-91. * Co-first author). Asrar, S., Zhou, Z., Ren, W., and Jia, Z. (2009). Ca-permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II. PLoS ONE 4, e4339. Zhou, Z., Meng, Y., Asrar, S., Todorovski, Z., and Jia, Z. (2009). A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. Neuropharmacology 56, 81-9. Jia, Z.P., Todorovski, Z., Meng, Y.H., Asrar, S., and Wang, L.Y. (2009). LIMK-1 and actin regulation of spine and synaptic function. In: Squire, L.R. (ed) New Encyclopedia of Neuroscience. Volume 5,pp.467-472. Oxford: Academic Press Meng, J.S., Meng, Y.H., Hanna, A., Janus, C.,and Jia, Z.P. (2005) Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J. Neurosci. 25, 6641-6650 Meng, Y.H., Takahashi, T., Meng, J., Zhang, Y., Lu, G., Asrar, S., Nakamura, T., and Jia, Z.P. (2004) Regulation of ADF/cofilin phsophorylation and synaptic function by LIM-kinase. Neuropharmacology 47, 746-754