陈飞虹 - 东南大学 - 化学化工学院

个人简介

2003.9-2007.7 中国药科大学，药学专业，获学士学位 2007.9-2010.7 中国药科大学，肿瘤药理学专业，获硕士学位 2010.9-2014.7 中国药科大学，肿瘤药理学专业，获博士学位 2012.9-2014.3 哈佛大学医学院Dana Farber癌症研究所，联合培养博士 2014.6-2018.4 2018.5-至今东南大学化学化工学院，江苏省生物药物高技术研究重点实验室，讲师东南大学化学化工学院，江苏省生物药物高技术研究重点实验室，副教授

研究领域

金属类等其它化疗药物的抗肿瘤作用和机制研究化疗药物的抗肿瘤耐药作用和机制研究

近期论文

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1. Feihong Chen(陈飞虹),Xiufeng Jin, Jian Zhao, Shaohua Gou*. DN604: A platinum(II) drug candidate with classic SAR can induce apoptosisvia suppressing CK2-mediated p-cdc25C subcellular localization in cancercells. Experimental Cell Research,2018, 364, 68-83. 2. Hong Chen, Feihong Chen (陈飞虹，并列一作), Weiwei Hu, Shaohua Gou*. Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria. Journal of Inorganic Biochemistry, 2018, 180, 119-128. 1. Feihong Chen(陈飞虹),Xiaochao Huang, Mian Wu, Shaohua Gou*, Weiwei Hu. A CK2-targeted Pt(IV) prodrug to disrupt DNA damage response. Cancer Letters,2017, 385, 168-178. 2. Feihong Chen(陈飞虹), Xiaodong Qin, Gang Xu, Shaohua Gou*, Xiufeng Jin. Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-kappa B pathways. Biochemical Pharmacology, 2017, 135, 50-68 3. Feihong Chen(陈飞虹), Gang Xu, Xiaodong Qin, Xiufeng Jin and Shaohua Gou*. Hybrid of DNA-targeting chlorambucil with Pt(IV) species to reverse drug resistance. The Journal of Pharmacology and Experimental Therapeutics, 2017, 363(2), 221-239 4.Feihong Chen(陈飞虹), Xinyi Wang, Xiufeng Jin, Jian Zhao, Shaohua Gou*. Oxidative DNA double strand breaks and autophagy in theantitumor effect of sterically hindered platinum(II) complexesin NSCLCs.Oncotarget, 2017,8(19), 30933-30955 5. Feihong Chen*(陈飞虹), Dan Wang. Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glioma model. American Journal of Translational Research, 2017, 9(5), 2243-2254. 6. Zhiping Zhou, Feihong Chen (陈飞虹，并列一作), Gang Xu, Shaohua Gou*, Study on the cytotoxic activity of platinum(II) complexes of (1R,2R)-N-1-cyclopentyl-1,2-cyclohexanediamine with substituted malonate derivatives. Bioorganic Medicinal Chemistry Letters. 2016, 26(2), 322-327 1. Feihong Chen(陈飞虹), Na Lu, Haiwei Zhang, Li Zhao, Licheng He, Haopeng Sun, Qidong You, Zhiyu Li, Qinglong Guo*. LYG-202 augments tumor necrosis factor-alpha-induced apoptosis via attenuating casein kinase 2-dependent nuclear factor-kappaB pathway in HepG2 cells. Molecular Pharmacology, 2012, 82(5):958-971. 2. Haopeng Sun, Feihong Chen(陈飞虹,共同一作), Xiaojian Wang, Zongliang Liu, Qian Yang, Xiaojin Zhang, Jia Zhu, Lei Qiang, Qinglong Guo*, Qidong You. Studies on gambogic acid (IV): Exploring structure-activity relationship with IkappaB kinase-beta (IKKbeta)，European Journal of Medicinal Chemistry, 2012, 51:110-123. 2010 1. Feihong Chen (陈飞虹)，Linbo Zhang，Lei Qiang，Zhen Yang，Tian Wu，Meijuan Zou，Lei Tao，Qidong You，Zhiyu Li，Yong Yang，Qinglong Gu*, Reactive oxygen species-mitochondria pathway involved in LYG-202-induced apoptosis in human hepatocellular carcinoma HepG2 cells，Cancer Letters, 2010, 296(1):96-105.