朱真 - 东南大学 - 微电子学院

个人简介

2002~2006 东南大学电子科学与工程学院，本科 2006~2008 东南大学电子科学与工程学院，硕士 2009~2014 瑞士苏黎世联邦理工学院（ETH Zurich）系统生物系（D-BSSE），博士 2014 瑞士ETH Zurich，博士后研究员。 2014~至今东南大学电子科学与工程学院MEMS教育部重点实验室、国家示范性微电子学院已发表期刊及国际会议论文近50篇，包括Lab Chip，Nanoscale，Sensors and Actuators B: Chemical，Scientific Reports, MicroTAS, IEEE Transducers, IEEE MEMS等，相关论文已被Science，Chemical Reviews等顶级期刊所引用；2018年，在2001年诺贝尔生理医学奖得主Paul Nurse参与出版Nature Springer丛书中以第一作者贡献一章；另有授权中国发明专利4项。曾受邀在APCOT 2016国际会议上作大会主题报告（Keynote）；担任IEEE Transducers 2017国际会议的Technical Program Committee Member；担任MicroTAS 2019国际会议的Promotion Committee Member；长期担任Sensors and Actuators B: Chemical, Scientific Reports, Analytical and Bioanalytical Chemistry, IEEE Access, IEEE Transactions on Biomedical Engineering, Micromachines等期刊的独立审稿人、仲裁审稿人。承担项目/课题（Funding & Projects）：国家重点研发计划“重大科学仪器设备开发”重点专项（2018.10-2021.09），在研，合作单位负责人国家自然科学基金面上项目（2018.01-2021.12），在研，项目负责人国家重点基础研究发展计划（973计划）（2015.01-2019.08），已结题，二级课题负责人国家自然科学基金青年项目（2015.01-2017.12），已结题，项目负责人南京市留学回国人员科技活动项目择优资助经费（2015.01-2016.12），已结题，项目负责人专著章节（Book Chapter） Z. Zhu*, O. Frey, and A. Hierlemann, Chapter 13, Wide-band Electrical Impedance Spectroscopy (EIS) Measures S. pombe Cell Growth in vivo (Chapter 13). In: Singleton T. (eds) Schizosaccharomyces pombe: Methods and Protocols, Methods in Molecular Biology, vol 1721, 2018, Springer Nature, New York, NY.（2001年诺贝尔生理医学奖得主Paul Nurse参与该书编撰）人才计划及科研奖励（Awards） 2015年入选江苏省“双创计划”之“双创博士”资助对象 2019年获国家科技进步二等奖，高性能MEMS器件设计与制造关键技术及应用，9/10

研究领域

立足于电子科学与微电子学专业，将微流控、生物传感、微纳制造、MEMS、3D打印、嵌入式系统等工程技术集成到“芯片实验室”（Lab-on-a-Chip），以此在生命科学、精准医疗诊断等领域开展以单细胞−模式生物-人体为对象的交叉学科研究。具体包括： 1. 基于电阻抗谱（Electrical Impedance Spectroscopy, EIS）的单细胞衰老寿命分析、胚胎发育监测、线虫分选等研究； 2. 基于电阻抗断层扫描成像（Electrical Impedance Tomography, EIT）的线虫运动记录、人体区域肺功能实时监测等研究； 3. 基于机器学习和神经网络算法的细胞表型分析、动物行为识别、EIT图像重构等研究。 Based on electronic and microelectronic engineering, our interdisciplinary research focuses on the integration of microfluidics, biosensors, advanced manufacturing and embedded systems into Lab-on-a-Chip applied in life science and precision medicine with the objects of single cells, model animals and human organs. Including： 1. EIS-based single-cell aging and lifespan determination, embryonic development monitoring and C. elegans worm sorting; 2. EIT-based worm locomotion and human regional lung function monitoring; 3. Machine-learning and neural-network algorithms for cell morphology analysis, animal behavior recognition and EIT image reconstruction.

近期论文

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K. Huang, Y. Geng, X. Zhang, D. Chen, Z. Cai, M. Wang, Z. Zhu*, and Z. Wang*, A wide-band digital lock-in amplifier and its application in microfluidic impedance measurement, Sensors, 2019, 19, 3519. K. Jia, Z. Lu, F. Zhou, Z. Xiong, R. Zhang, Z. Liu, Y. Ma, L. He, C. Li, Z. Zhu, D. Pan, and Z. Lian, Multiple sgRNAs facilitate base editingmediated i-stop to induce complete and precise gene disruption, Protein & Cell, 2019. Y. Geng, Z. Zhu*, Y. Wang, Y. Wang, S. Ouyang, K. Zheng, W. Ye, Y. Fan, Z. Wang, and D. Pan, Multiplexing microelectrodes for dielectrophoretic manipulation and electrical impedance measurement of single particles and cells in a microfluidic device, Electrophoresis, 2019, 40: 1436-1445. Z. Zhu*, Y. Geng, Z. Yuan, S. Ren, M. Liu, Z. Meng, and D. Pan, A bubble-free microfluidic device for easy-to-operate immobilization, culturing and monitoring of zebrafish embryos, Micromachines, 2019, 10: 168. Z. Zhu*, W. Chen, B. Tian, Y. Luo, J. Lan, D. Wu, D. Chen, Z. Wang, and D. Pan, Using microfluidic impedance cytometry to measure C. elegans worms and identify their developmental stages, Sensors and Actuators B: Chemical, 2018, 275: 470-482. Z. Zhu*, X. Xu, L. Fang, D. Pan, and Q.-A. Huang, Investigation of geometry-dependent sensing characteristics of microfluidic electrical impedance spectroscopy through modeling and simulation, Sensors and Actuators B: Chemical, 2016, 235: 515-524. Z. Zhu*, P. Chen, K. Liu, and C. Escobedo, A versatile bonding method for PDMS and SU-8 and its application towards a multifunctional microfluidic device, Micromachines, 2016, 7: 230. Z. Zhu*, O. Frey, N. Haandbæk, F. Franke, F. Rudolf, and A. Hierlemann, Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells, Scientific Reports, 2015, 5, 17180. K. Liu, Z. Zhu*, X. Wang, D. Gonçalves, B. Zhang, A. Hierlemann, and P. Hunziker*, Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery, Nanoscale, 2015, 7: 16983-16993. Z. Zhu*, O. Frey, F. Franke, N. Haandbæk, and A. Hierlemann, Real-time monitoring of immobilized single yeast cells through multi-frequency electrical impedance spectroscopy, Analytical and Bioanalytical Chemistry, 2014, 406: 7015-7025. Z. Zhu*, O. Frey, D. S. Ottoz, F. Rudolf, and A. Hierlemann, Microfluidic single-cell cultivation chip with controllable immobilization and selective release of yeast cells, Lab on a Chip, 2012, 12: 906-915.