Simpson, Julie H - University of California, Santa Barbara - Biomolecular Science and Engineering

个人简介

University of Wisconsin Madison 2001-2005: Helen Hay Whitney Post-Doctoral Fellow: Ganetzky Lab, Genetics Dept University of California Berkeley 1996-2001: HHMI Predoctoral Fellow Goodman Lab, MCB Dept Universidad de Costa Rica 1995-1996: Labouisse Fellow Espinoza Lab, CIBCM Princeton University 1991-1995: AB Hiromi Lab, MB Dept How does the brain control behavior? I've been investigating aspects of this question for my whole scientific career. From Punnet Squares in high school, I was hooked on a genetic approach. I learned about axon guidance and Drosophila in college by doing lab work on the R7 photoreceptor cell in the fly eye. Exploring how expression of different Roundabout receptors set neuron positions during the development of the embryonic midline showed me the beauty of visual read-outs of genetic manipulations. Temperature-sensitive mutants in ion channel genes could be used to screen for behaviorally-critical neurons. I started my own lab at the HHMI Janelia Research Campus in 2006 to investigate neural circuits coordinating complex behaviors in flies. We developed tools to visualize and manipulate specific neurons and studied several behaviors - feeding, proboscis extension, courtship song, and grooming. In 2015, I moved to the University of California Santa Barbara, where my lab will focus on how complex motor sequences are controlled by specific neural circuits.

研究领域

Genetics, Neural Circuits, and Motor sequences

近期论文

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McKellar CE, Lillvis JL, Bath DE, Fitzgerald JE, Cannon JG, Simpson JH, Dickson BJ. 2019. Threshold-Based Ordering of Sequential Actions during Drosophila Courtship.. Curr Biol. Louis M, Simpson JH. 2018. Disentangling the strings that organize behavior.. Elife. 7 Simpson JH, Looger LL. 2018. Functional Imaging and Optogenetics in Drosophila. Genetics. 208(4):1291-1309. Robie AA, Hirokawa J, Edwards AW, Umayam LA, Lee A, Phillips ML, Card GM, Korff W, Rubin GM, Simpson JH et al.. 2017. Mapping the Neural Substrates of Behavior.. Cell. 170(2):393-406.e28. Hampel S, McKellar CE, Simpson JH, Seeds AM. 2017. Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila. Elife. 6 O'Connor-Giles KM, Zhang B, Simpson JH, Wu C-F. 2016. The neurogenetics of Drosophila: the Ganetzky legacy.. J Neurogenet. 30(3-4):149-151. Simpson JH. 2016. Rationally subdividing the fly nervous system with versatile expression reagents.. J. Neurogenetics. 30(3-4) Knapp J-M, Chung P, Simpson JH. 2015. Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase.. Genetics. 199(4):919-34. Ohyama T, Schneider-Mizell CM, Fetter RD, Aleman JValdes, Franconville R, Rivera-Alba M, Mensh BD, Branson KM, Simpson JH, Truman JW et al.. 2015. A multilevel multimodal circuit enhances action selection in Drosophila.. Nature. 520(7549):633-9. Hampel S, Franconville R, Simpson JH, Seeds AM. 2015. A neural command circuit for grooming movement control.. Elife. 4 Albin SD, Kaun KR, Knapp J-M, Chung P, Heberlein U, Simpson JH. 2015. A Subset of Serotonergic Neurons Evokes Hunger in Adult Drosophila.. Curr Biol. 25(18):2435-40. Atasoy D, J Betley N, Li W-P, Su HH, Sertel SM, Scheffer LK, Simpson JH, Fetter RD, Sternson SM. 2014. A genetically specified connectomics approach applied to long-range feeding regulatory circuits.. Nat Neurosci. 17(12):1830-9. Seeds AM, Ravbar P, Chung P, Hampel S, Midgley FM, Mensh BD, Simpson JH. 2014. A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila.. Elife. 3:e02951. Ito K, Shinomiya K, Ito M, J Armstrong D, Boyan G, Hartenstein V, Harzsch S, Heisenberg M, Homberg U, Jenett A et al.. 2014. A systematic nomenclature for the insect brain.. Neuron. 81(4):755-65.