Shraiman, Boris - University of California, Santa Barbara - Biomolecular Science and Engineering

个人简介

I am a theoretical physicist with background in statistical physics. PhD 1983 Harvard, postdoctoral fellow at U. Chicago and Bell Labs; Member of Technical Staff at Bell Labs, in the Theoretical Physics Department at Murray Hill for 16 years. Worked on a range of physics problems from correlated electrons and superconductivity to pattern formation and turbulence. Started working on biology problems about 20 years ago, while at Bell Labs. Moved to the present position as a Permanent Member of KITP and a Professor in the UCSB Dept of Physics in 2004, after two years as a Physics Professor at Rutgers.

研究领域

Morphogenesis, addressing the problem of “Growth and Form” in animal development. Statistical Genetics, which aims to quantitatively describe evolutionary dynamics in populations. In both subjects my work focuses on the role of interactions. In the case of morphogenesis, these are interactions between cells; in the case of population genetics, the interactions are between genetic polymorphisms. The study of “interactions” both in the developmental biology and in population genetics contexts brings up unexpected but direct and useful connections with statistical physics. Discovering, exploring and exploiting these connections in order to develop new understanding of the biological problems, is the main goal of my research. As a permanent member of KITP I am also deeply involved with developing interdisciplinary programs at KITP aimed at building up the interdisciplinary physics/biology community.

近期论文

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Streichan SJ, Noll N., Lefebvre M, Wieschaus E., Shraiman BI, Global morphogenetic flow is completely determined by myosin distribution in Drosophila embryo, arXiv:1701.07100 (2017). Noll N., Mani M., Heemskerk I., Streichan S. and Shraiman BI, “Active Tension Network model of epithelial mechanics suggests an exotic mechanical state realized in epithelial tissue”, arXiv: 1508.00623v1 (2015) and Nature Physics, doi:10.1038/nphys4219, (2017) Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB. "Inferring Cell-State Transition Dynamics from Lineage Trees and Endpoint Single-Cell Measurements." Cell Syst. 3(5):419-433 (2016). Alim K, Armon S, Shraiman BI, Boudaoud A, "Leaf growth is conformal." Phys Biol. 13(5):05LT01, (2016). Pan Y., Heemskerk I., Ibar C., Shraiman BI., and Irvine KD.”Differential growth triggers mechanical feedback that elevates Hippo signaling”, Proc. Nat. Acad. Sci USA113(45):E6974-83, (2016). Neher RA, Bedford T., Daniels RS, Russell CA and Shraiman BI, “Prediction, dynamics and visualization of antigenic phenotypes of seasonal influenza viruses”, Proc. Nat. Acad. Sci USA 113(12):E1701-9, (2016). Hormoz S, Desprat N, Shraiman BI. “Inferring epigenetic dynamics from kin correlations”, PNAS 112(18):E2281-9 (2015). Neher RA, Russell CA, Shraiman BI., “Predicting evolution form the shape of genealogical trees”, Elife 3: eLife.03568 (2014). Dayarian A. and Shraiman BI., "How to infer relative fitness from a sample of genomic sequences", arXiv:1208.5954 and Genetics 197(3):913-23 (2014) Mani M., Goyal S., Irvine KD and Shraiman BI. “Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling” PNAS 110 (51): 20420-20425 (2013) Neher RA, Kessinger TA. and Shraiman BI.,” Coalescence and genetic diversity in sexual populations under selection”, PNAS 110(39): 15836-15841 (2013). Fisher DS, Laessig M and Shraiman BI, “Evolutionary dynamics and statistical physics”, JSTAT, Special Issue, N01001 (2013) Neher RA, Vucelja M, Mezard M and Shraiman BI, “Emergence of clones in sexual populations”, arXiv:1205.2059 and JSTAT Special Issue, P01008 (2013) Neher RA and Shraiman BI, “Fluctuation of Fitness Distributions and the Rate of Muller’s Ratchet”, Genetics 191(4):1283-93 (2012). Chiou K., Hufnagel L. and Shraiman B.I, “Mechanical Stress Inference for Two Dimensional Cell Arrays”, arXiv:1112.5905 and PLoS Comp Biol. 8(5):e1002512 (2012). Puliafito A, Hufnagel L, Neveu P, Streichan S, Sigal A, Fygenson DK, Shraiman BI. "Collective and single cell behavior in epithelial contact inhibition", Proc Natl Acad Sci U S A. 109(3): 739-744 (2012). Lubensky D., Shraiman B.I. and Baker N., “Dynamic patterning in Drosophila eye development”, Proc Natl Acad Sci U S A. 108(27):11145-50, (2011). Neher R. and Shraiman B.I.,"Statistical genetics and evolution of quantitative traits", Rev. Mod. Phys. 83: 1301,( 2011). Neher R. and Shraiman B.I. “Genetic Draft and Quasi-Neutrality in Large Sexual Populations”, Genetics 188(4):975-96 (2011) Callahan B., Neher R., Bachtrog D, Andolfatto P. and Shraiman B.I., “Correlated evolution of nearby residues in Drosophilid proteins”, PLoS Genet. 7(2):e1001315 (2011). Pumir A. and Shraiman B.I., "Epistasis in a model of molecular signal transduction", PLoS Comput Biol. 7(5):e1001134 (2011). Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS, "MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states." Cell Stem Cell. 2010 Dec 3;7(6):671-81. Neher R., Shraiman B.I. and Fisher D.S. "Rate of adaptation in large sexual populations." Genetics 184(2):467-81 (2010). Burak Y. and Shraiman B.I. “Order and stochastic dynamics in Planar Cell Polarity”, PLoS Comp Biol. 5(12):e1000628 (2009). Callahan B., Thattai M. and Shraiman B.I. “Emergent gene order in the model of the modular polyketide syntase system”, Proc. Natl. Acad. Sci. USA, 106(46):19410-5 (2009). Neher R. and Shraiman B.I., “Competition between recombination and epistasis can cause a transition from allele to genotype selection”, Proc. Natl. Acad. Sci. USA, 106(16)6866-71, (2009).