Montell, Denise J - University of California, Santa Barbara

个人简介

Education Ph.D., Neuroscience, Stanford University B.S., Biochemistry and Cell Biology, UC San Diego Bio Dr. Denise Montell earned her B.S. degree in biochemistry and cell biology at the University of California, San Diego and her Ph.D. in Neuroscience at Stanford University. As an American Cancer Society postdoctoral fellow at the Carnegie Institution she developed a new model for studying cell motility in vivo using a powerful combination of cell biology and molecular genetic approaches. After only two years she attained an independent junior faculty position at the Carnegie and two years later became an Assistant Professor at the Johns Hopkins School of Medicine, rising to the rank of Full Professor in 2002. At the Johns Hopkins University School of Medicine she served as Director of the Graduate Program in Biological Chemistry for 10 years and was the founding director of the Center for Cell Dynamics, an interdisciplinary group of investigators from eight different departments who shared a common interest in observing and manipulating biochemical events and cellular behaviors in real time, in living cells, tissues and organisms. She currently serves on the Advisory Councils of both the American Cancer Society and the National Institutes of General Medical Sciences. She has recently joined the faculty of MCDB at UCSB to pursue her interests in research, teaching and program building.

研究领域

Cells face a continual struggle between life and death, fought at the biochemical level between pro-death and pro-survival stimuli. Denise Montell's lab has recently discovered a surprising reversibility of the cell suicide process known as apoptosis. Cells that have progressed far beyond steps previously considered to be points of no return can reverse the dying process, recover and go on to proliferate. This has both positive and negative consequences. We are testing the hypothesis that the ability of cells to return from the brink of death – which we have named anastasis (Greek: "rising to life") - serves to salvage cells that are difficult to replace such as heart muscle cells or neurons in the adult brain. Therefore discovering how to enhance anastasis holds the potential to lead to revolutionary new therapies for heart and neurodegenerative diseases. A second major interest of the lab focuses on cell motility. Without cell migrations embryos could not develop, wounds would not heal and the nervous and immune systems could neither form nor function. But cell movements have a dark side, and the ability to move also contributes to tumor metastasis, which is a major cause of death for cancer patients. Denise Montell's lab has developed a new in vivo model for the study of cell motility and employs a powerful combination of molecular genetics, live imaging and photo-manipulation techniques to decipher the molecular mechanisms that determine when, where and how cells move. A third interest in the lab is to understand how cells adopt the great diversity of shapes and behaviors that are found in nature. Our hypothesis is that a limited set of mechanochemical modules are deployed in a combinatorial fashion to create diversity, analogous to the way that a limited set of amino acids can be combined to create tremendous diversity in protein shape and function.

近期论文

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Sun G, Ding XAustin, Argaw Y, Guo X, Montell DJ. 2020. Akt1 and dCIZ1 promote cell survival from apoptotic caspase activation during regeneration and oncogenic overgrowth.. Nat Commun. 11(1):5726. Miao G, Godt D, Montell DJ. 2020. Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules.. Dev Cell. Mishra AK, Campanale JP, Mondo JA, Montell DJ. 2019. Cell interactions in collective cell migration. Development. 146(23) Mishra AK, Mondo JA, Campanale JP, Montell DJ. 2019. Coordination of protrusion dynamics within and between collectively migrating border cells by myosin II. Mol Biol Cell. 30(19):2490-2502. Stuelten CH, Parent CA, Montell DJ. 2018. Cell motility in cancer invasion and metastasis: insights from simple model organisms.. Nat Rev Cancer. 18(5):296-312. Montell DJ. 2018. Invite your representative to work. Change the world. Here's how.. Mol Biol Cell. 29(4):377-379. Chang Y-C, Wu J-W, Hsieh Y-C, Huang T-H, Liao Z-M, Huang Y-S, Mondo JA, Montell D, Jang AC-C. 2018. Rap1 Negatively Regulates the Hippo Pathway to Polarize Directional Protrusions in Collective Cell Migration.. Cell Rep. 22(8):2160-2175. Gudipaty SA, Conner CM, Rosenblatt J, Montell DJ. 2018. Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease.. Annu Rev Cell Dev Biol. 34:311-332. Campanale JP, Sun TY, Montell DJ. 2017. Development and dynamics of cell polarity at a glance.. J Cell Sci. 130(7):1201-1207. Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HRobin, Kosik KS, Montell DJ. 2017. A molecular signature for anastasis, recovery from the brink of apoptotic cell death.. J Cell Biol. 216(10):3355-3368. Sun G, Montell DJ. 2017. Q&A: Cellular near death experiences-what is anastasis? BMC Biol. 15(1):92. Dai W, Peterson A, Kenney T, Burrous H, Montell DJ. 2017. Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.. Nat Commun. 8(1):1244. Cho A, Kato M, Whitwam T, Kim JHoon, Montell DJ. 2016. An Atypical Tropomyosin in Drosophila with Intermediate Filament-like Properties.. Cell Rep. 16(4):928-938. Ding AXun, Sun G, Argaw YG, Wong JO, Easwaran S, Montell DJ. 2016. CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo.. Elife. 5 Dai W, Montell DJ. 2016. Live Imaging of Border Cell Migration in Drosophila.. Methods Mol Biol. 1407:153-68. Cai D, Dai W, Prasad M, Luo J, Gov NS, Montell DJ. 2016. Modeling and analysis of collective cell migration in an in vivo three-dimensional environment.. Proc Natl Acad Sci U S A. 113(15):E2134-41. Xiang W, Zhang D, Montell DJ. 2016. Tousled-like kinase regulates cytokine-mediated communication between cooperating cell types during collective border cell migration.. Mol Biol Cell. 27(1):12-9. Prasad M, Wang X, He L, Cai D, Montell DJ. 2015. Border Cell Migration: A Model System for Live Imaging and Genetic Analysis of Collective Cell Movement.. Methods Mol Biol. 1328:89-97. Pocha SM, Montell DJ. 2014. Cellular and molecular mechanisms of single and collective cell migrations in Drosophila: themes and variations.. Annu Rev Genet. 48:295-318. Cai D, Montell DJ. 2014. Diverse and dynamic sources and sinks in gradient formation and directed migration.. Curr Opin Cell Biol. 30:91-8.