Lillemeier, Bjorn - University of California, San Diego

研究领域

The Lillemeier laboratory studies the spatio-temporal organization of the plasma membrane and its impact on signal transduction. We are specifically interested in T cell antigen recognition, activation and signaling. We are also investigating other aspects of membrane biology, e.g. virus-host interactions, anthrax toxin uptake and membrane aging. To achieve this, our research team uses cutting edge fluorescence microscopy techniques, e.g. super-resolution microscopy and cross-correlation spectroscopy. Another focus in the laboratory is to study the qualitative and quantitative differences of signal transduction that determine T cell faith and function. To this end, we use innovative biochemical and molecular biological approaches.

近期论文

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Klammt C., Lillemeier B.F. (2012). How membrane structures control T cell signaling. Frontiers Immunol. 3:291. Kasuboski J.M., Sigal Y.J., Joens M.S., Lillemeier B.F., and Fitzpatrick J.A.J. (2012). Superresolution microscopy: A comparative treatment. Curr. Protocols Cytometry 2.17.1–2.17.24. Fitzpatrick J.A., Lillemeier B.F. (2011). Fluorescence correlation spectroscopy: linking molecular dynamics to biological function in vitro and in situ. Curr. Opin. Struct. Biol. 21:650-660. Lillemeier B.F. and Davis M.M. (2011). Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy. Meth. Mol. Biol. 748:169-182. Kuhns M.S., Girvin A.T., Klein L.O., Chen R., Jensen K.D., Newell E.W., Huppa J.B., Lillemeier B.F., Huse M., Chien Y.H., Garcia K.C., Davis M.M. (2010). Evidence for a functional sidedness to the alpha-beta-TCR. PNAS USA 107:5094-5099. Huppa J.B., Axmann M., Mörtelmaier M.A., Lillemeier B.F., Newell E.W., Brameshuber M., Klein L.O., Schütz G.J., Davis M.M. (2010). Measuring the affinity and kinetics of T cell receptor binding in situ. Nature 463:963-967. Lillemeier B.F., Mörtelmaier M.A., Forstner M.B., Huppa J.B., Groves J.T., Davis M.M. (2010). TCR and LAT are expressed on separate protein islands onT cell membranes and concatenate during activation. Nature Immunol. 11:90-96. Davis M.M., Krogsgaard M., Huse M., Huppa J., Lillemeier B.F., Li Q.J. (2007). T cells as a self-referential, sensory organ. Ann. Rev. Immunol. 25:681-695. Lillemeier B.F., Pfeiffer J.R., Surviladze Z., Wilson B.S., Davis M.M. (2006). Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. PNAS USA 103:18992-18997. Huse M., Lillemeier B.F., Kuhns M.S., Chen D.S., Davis M.M. (2006). T cells use two directionally distinct pathways for cytokine secretion. Nature Immunol. 7:247-55. Kerr I.M., Costa-Pereira A.P., Lillemeier B.F., Strobl B. (2003). Of JAKs, STATs, blind watchmakers, jeeps and trains. FEBS Lett. 546:1-5. Hilkens CM, Is'harc H, Lillemeier BF, Strobl B, Bates PA, Behrmann I, Kerr IM. (2001). A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. FEBS Lett. 7:87-91. Lillemeier B.F., Köster M., Kerr I.M. (2001). STAT1 from the cell membrane to the DNA. EMBO J. 20:2508-2517. van Ham M., van Lith M., Lillemeier B.F., Tjin E., Gruneberg U., Rahman D., Pastoors L., van Meijgaarden K., Roucard C., Trowsdale J., Ottenhoff T., Pappin D., Neefjes J. (2000). Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J. Exper. Med. 191(7):1127-1136.