Sorensen, ErikJ. - 天津大学 - 药物科学与技术学院

个人简介

Professor Sorensen was born and raised in upstate New York and received his B. A. degree in Chemistry from Syracuse University, where he performed undergraduate research with Professor Roger Hahn. In 1989, he began his graduate studies in chemical synthesis at the University of California, San Diego. Under the direction of Professor K. C. Nicolaou, he synthesized a novel family of DNA cleaving, 10-membered ring enediynes, contributed to a laboratory synthesis of the cancer drug taxol and co-authored a book titled Classics in Total Synthesis, and obtained his Ph. D. degree in 1995. From 1995-1997, he was a National Science Foundation postdoctoral fellow in the laboratory of Professor Samuel Danishefsky at The Memorial Sloan-Kettering Cancer Center in New York, where he contributed to total syntheses of the epothilone class of antitumor agents. In 1997, he started his independent career at The Scripps Research Institute and became an Associate Professor with tenure in 2001. In 2003, he moved his research group to Princeton University where he is the Arthur Allan Patchett Professor in Organic Chemistry. The Sorensen laboratory is interested in the field of complex chemical synthesis, questions about the structural origins of architecturally unique natural products, and evaluating hypotheses about the chemical basis of the biological activities of natural products and non-natural molecules. His research aims to increase the capabilities of organic synthesis through the development of powerful reactions and strategies. For his achievements in chemical research and education, Professor Sorensen received a Beckman Young Investigator Award, a Camille Dreyfus Teacher-Scholar Award, the AstraZeneca Award for Excellence in Chemistry, the Lilly Grantee Award, the Pfizer Global Research Award for Excellence in Organic Chemistry, and the Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry. In 2001, Professor Sorensen was a Woodward Scholar at Harvard University. In 2007, he was the Givaudan/Karrer Distinguished Visiting Professor at the University of Zürich. In 2009, he received the Arthur C. Cope Scholar Award from the American Chemical Society.

研究领域

Our laboratory pursues ideas and chemical reactions that have the potential to advance the field of organic synthesis. The molecular architectures of physiologically active natural products inspire us to consider bold strategies for rapidly generating their intricate structures from relatively simple chemicals. We embrace risk-taking during the creative process of synthesis design and seek new ways for thinking about synthesis.

近期论文

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Exploring the Chemical Space of Proluciferins as Probe Substrates for Human Cytochrome P450 Enzymes Zhao Jie,Zhang Xue,Wang Yueyin,Huang Huimin,Sharma Shishir,Sharma Sangeeta Shrestha,Wolf Clemens Alexander,Liu Sijie,Wolber Gerhard,Sorensen Erik J.,Bureik Matthias Appl Biochem Biotechnol 195, 1042–1058 (2023). https://doi.org/10.1007/s12010-022-04184-0 A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization Journal of the American Chemical Society 2022-08-10 | Journal article DOI: 10.1021/jacs.2c06504 CONTRIBUTORS: John F. Hoskin; Erik J. Sorensen Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)–H Arylation with a Transient Directing Group Journal of the American Chemical Society 2021-12-08 | Journal article DOI: 10.1021/jacs.1c09368 CONTRIBUTORS: Philip A. Provencher; John F. Hoskin; Jonathan J. Wong; Xiangyang Chen; Jin-Quan Yu; K. N. Houk; Erik J. Sorensen A C–H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B2 Organic Letters 2021-12-17 | Journal article DOI: 10.1021/acs.orglett.1c03502 CONTRIBUTORS: Nicholas A. Falcone; Aaron T. Bosse; Hojoon Park; Jin-Quan Yu; Huw M. L. Davies; Erik J. Sorensen Conversion of five proluciferin esters by human cytochrome P450 enzymes Biotechnology Journal 2021-07 | Journal article DOI: 10.1002/biot.202100007 CONTRIBUTORS: Shishir Sharma; Sangeeta Shrestha Sharma; Xue Zhang; Jan‐Philipp Bureik; Erik J. Sorensen; Matthias Bureik Cyclization by C(sp3)–H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes ACS Catalysis 2021-03-05 | Journal article DOI: 10.1021/acscatal.0c05081 CONTRIBUTORS: Philip A. Provencher; Katherine L. Bay; John F. Hoskin; K. N. Houk; Jin-Quan Yu; Erik J. Sorensen New Proluciferin Substrates for Human CYP4 Family Enzymes Applied Biochemistry and Biotechnology 2021-01-01 | Journal article DOI: 10.1007/s12010-020-03388-6 CONTRIBUTORS: Jingyao Liu; David Machalz; Gerhard Wolber; Erik J. Sorensen; Matthias Bureik New luciferin-based probe substrates for human CYP26A1 Biochemistry and Biophysics Reports 2020-12 | Journal article DOI: 10.1016/j.bbrep.2020.100861 CONTRIBUTORS: Shishir Sharma; Jingyao Liu; Xue Zhang; Sangeeta Shrestha Sharma; Erik J. Sorensen; Matthias Bureik Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1 Du Wei,Machalz David,Yan Qi,Sorensen Erik J.,Wolber Gerhard,Bureik Matthias Page:113850 ISSN:0006-2952 2020 Container-title:Biochemical Pharmacology Donor–Acceptor–Acceptor 1,3-Bisdiazo Compounds: An Exploration of Synthesis and Stepwise Reactivity Organic Letters 2020-03-06 | Journal article DOI: 10.1021/acs.orglett.0c00103 CONTRIBUTORS: Dylan J. Abrams; Huw M. L. Davies; Erik J. Sorensen